74118-1
P27 Ag [Presence] in Tissue by Immune stain
Active
Part Description
LP173614-1 P27
Cell cycle progression is regulated by cyclins and their cognate cyclin-dependent kinases (Cdks). P27 (Kip1) is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. P27 binds to and inhibits cyclinE-Cdk2, cyclinA-CDK2 and cyclinD1-CDK4 complex and enforce the G1 restriction point. It is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. P27 is up regulated in quiescent cells and in cells treated with cAMP and antimitogenic stimuli. P27 is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitylation and degradation of p27; while phosphorylation by hKIS on S10 signals the nuclear export to the cytoplasm.
Source: LOINC partner 1
Fully-Specified Name
- Component
- P27 Ag
- Property
- PrThr
- Time
- Pt
- System
- Tiss
- Scale
- Ord
- Method
- Immune stain
Additional Names
- Short Name
- P27 Ag Tiss Ql ImStn
- Display Name
- P27 Ag Immune stain Ql (Tiss)
- Consumer Name Alpha Get Info
- P27 antigen, Tissue
Example Answer List: LL360-9
Source: Regenstrief Institute| Answer | Code | Score | Answer ID |
|---|---|---|---|
| PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
| NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Basic Attributes
- Class
- PATH
- Type
- Laboratory
- First Released
- Version 2.46
- Last Updated
- Version 2.56
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | P27 Antígeno: |
| es-MX | Spanish (Mexico) | P27 Ag: |
| fr-FR | French (France) | P27 antigène: |
| it-IT | Italian (Italy) | P27 , Ag: Synonyms: Patologia Presenza o Soglia Punto nel tempo (episodio) Tessuto & |
| nl-NL | Dutch (Netherlands) | p27 Ag: Synonyms: antigeen |
| pt-BR | Portuguese (Brazil) | P27 Ag: |
| ru-RU | Russian (Russian Federation) | P27 Аг: Synonyms: Порядковый Ткань и мазки Точка во времени; |
| tr-TR | Turkish (Turkey) | P27 Ag: Synonyms: Antijen Mevcut |
| zh-CN | Chinese (China) | P27 抗原: Synonyms: Ag Kip1; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=74118-1
Third Party Copyright
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LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright