Version 2.80

Part Description

LP173614-1   P27
Cell cycle progression is regulated by cyclins and their cognate cyclin-dependent kinases (Cdks). P27 (Kip1) is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. P27 binds to and inhibits cyclinE-Cdk2, cyclinA-CDK2 and cyclinD1-CDK4 complex and enforce the G1 restriction point. It is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. P27 is up regulated in quiescent cells and in cells treated with cAMP and antimitogenic stimuli. P27 is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitylation and degradation of p27; while phosphorylation by hKIS on S10 signals the nuclear export to the cytoplasm. Source: LOINC partner 1

Fully-Specified Name

Component
P27 Ag
Property
PrThr
Time
Pt
System
Tiss
Scale
Ord
Method
Immune stain

Additional Names

Long Common Name
P27 Ag [Presence] in Tissue by Immune stain
Short Name
P27 Ag Tiss Ql ImStn
Display Name
P27 Ag Immune stain Ql (Tiss)
Consumer Name Alpha Get Info
P27 antigen, Tissue

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.46
Last Updated
Version 2.56 (MIN)
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) P27 Αντιγόνο:PrThr:Pt:Ιστός:Ord:Ανοσολογική χρώση
Synonyms: P27 PrThr
es-ES Spanish (Spain) P27 Antígeno:PrThr:Punto temporal:Tejido:Ord:Tinción de inmunohistoquímica
es-MX Spanish (Mexico) P27 Ag:Presencia o umbral:Punto temporal:Tejido y frotis:Ordinal:Mancha inmune
fr-FR French (France) P27 antigène:Présence/Seuil:Ponctuel:Tissu:Qualitatif:Coloration immune
it-IT Italian (Italy) P27, Ag:PrThr:Pt:Tessuto:Ord:Colorazione immunologica
Synonyms: Patologia Presenza o Soglia Punto nel tempo (episodio) Tessuto & Strisci
nl-NL Dutch (Netherlands) p27 Ag:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:immunokleuring
Synonyms: antigeen
pt-BR Portuguese (Brazil) P27 Ag::Pt:Tecido:Ord:Imunocoloração
ru-RU Russian (Russian Federation) P27 Аг:PrThr:ТчкВрм:Тк:Пор:Иммуногистохимическая окраска
Synonyms: Порядковый Ткань и мазки Точка во времени;Момент
tr-TR Turkish (Turkey) P27 Ag:MevcEşik:Zmlı:Doku:Srl:İmmün boyama
Synonyms: Mevcut
zh-CN Chinese (China) P27 抗原:存在情况或阈值:时间点:组织与涂片:序数型:免疫染色法
Synonyms: Ag Kip1;细胞周期蛋白依赖性激酶抑制剂 Cip/Kip 家族成员;member of Cip/Kip family of cyclin-dependent kinase inhibitors 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫染色;免疫组化;免疫组化染色;免疫组化染色法;免疫组化法;免疫组织化学染色;免疫组织化学染色法;细胞免疫染色;细胞免疫染色法 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 染法 染色方法 染色法 着色 着色方法 着色法

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=74118-1