LOINC
Version 2.67

74118-1P27 Ag [Presence] in Tissue by Immune stainActive

Part Description

LP173614-1   P27
Cell cycle progression is regulated by cyclins and their cognate cyclin-dependent kinases (Cdks). P27 (Kip1) is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. P27 binds to and inhibits cyclinE-Cdk2, cyclinA-CDK2 and cyclinD1-CDK4 complex and enforce the G1 restriction point. It is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. P27 is up regulated in quiescent cells and in cells treated with cAMP and antimitogenic stimuli. P27 is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitylation and degradation of p27; while phosphorylation by hKIS on S10 signals the nuclear export to the cytoplasm. Source: LOINC partner 1

Fully-Specified Name

Component
P27 Ag
Property
PrThr
Time
Pt
System
Tiss
Scale
Ord
Method
Immune stain

Additional Names

Short Name
P27 Ag Tiss Ql ImStn
Display Name
P27 Ag Immune stain Ql (Tiss)

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.46
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
P27 抗原:存在情况或阈值:时间点:组织与涂片:序数型:免疫染色法
nl-NLDutch (NETHERLANDS)
p27 Ag:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:immunokleuring
fr-FRFrench (FRANCE)
P27 antigène:Présence/Seuil:Ponctuel:Tissu:Qualitatif:Coloration immune
it-ITItalian (ITALY)
P27 , Ag:PrThr:Pt:Tessuto:Ord:Colorazione immunologica
pt-BRPortuguese (BRAZIL)
ru-RURussian (RUSSIAN FEDERATION)
P27 Аг:PrThr:ТчкВрм:Тк:Пор:Иммуногистохимическая окраска
es-ESSpanish (SPAIN)
P27 Antígeno:PrThr:Punto temporal:Tejido:Ord:Tinción de inmunohistoquímica
tr-TRTurkish (TURKEY)
P27 Ag:MevcEşik:Zmlı:Doku:Srl:İmmün boyama

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=74118-1