74304-7

PRRSV neutralizing antibody [Titer] in Serum by Neutralization test

Active

Term Description

Quantitative result of porcine reproductive and respiratory syndrome virus (PRRSV)-neutralizing antibodies (NA) in serum. The submitter's lab performs a Fluorescent Focus Neutralization test.

Part Descriptions

LP14277-5 Porcine reproductive and respiratory syndrome virus
Porcine reproductive and respiratory syndrome virus (PRRSV), also referred to as Blue-Ear Pig disease, causes significant disease and can lead to reproductive failures such as weak fetuses, mummified fetuses, abortions or still borns. PRRSV is an RNA virus and belongs to the order Nidovirales, family Arteriviridae and the genus Arterivirus. PRRSV is spread among all ages of pigs and herds through direct and indirect contact. PRRSV is considered one of the most economically important infectious agents in the swine industry worldwide. The continual changing genomic characteristics of the various strains of this virus make testing of herds an important part of disease management. PMID: 26646630 Source: Regenstrief LOINC

LP207365-0 Ab.Neut
Neutralizing antibodies are antibodies that interfere with the interaction between the virus and its host cell receptor, therefore preventing infectivity. Neutralizing antibodies can be detected using a traditional VNT or other methods such as pseudovirus VNT and surrogate VNT. VNT and pseudovirus VNT use live virus (the actual virus or a recombinant virus that incorporates the viral antigen of interest, respectively) and cell culture to assess the virus-host interaction and whether neutralizing antibodies are present that block that interaction. Surrogate VNT (sVNT) does not use live virus but rather uses purified viral antigen and host cell receptor protein to mimic the same interaction. The sVNT method is currently (2021) represented in LOINC as IA, because it is an immunoassay-based method. Source: Regenstrief LOINC

LP6416-4 Neut
In LOINC, the Method "Neut" represents the virus neutralization test (VNT), also called conventional VNT, which is a specific laboratory method that is used primarily for identifying whether neutralizing antibodies for the virus of interest are present in the patient sample. The VNT involves incubating patient serum with the virus of interest, and then inoculating onto cell culture. If neutralizing antibodies are present and the virus is neutralized, the cells will not be infected. If neutralizing antibodies are not present, the virus will infect the cells in the cell culture. PMID: 32170698 This method can also be used to identify specific virus serotypes or strains, by performing separate tests in which serum is incubated with each of the specific virus serotypes or strains of interest. PMID: 169804 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Porcine reproductive and respiratory syndrome virus Ab.Neut:Titr:Pt:Ser:SemiQn:Neut
Long Common Name: PRRSV neutralizing antibody [Titer] in Serum by Neutralization test
Short Name: PRRSV NAb Titr Ser Nt
Display Name: PRRSV neut ab Neut test (S) [Titer]
Consumer Name Alpha Get Info: PRRSV neutralizing antibody, Blood

Part Model Get Info

Component
Porcine reproductive and respiratory syndrome virus Ab.Neut
LP249856-8
- Analyte
  Porcine reproductive and respiratory syndrome virus Ab.Neut
  LP249856-8
  - Component Numerator
    Porcine reproductive and respiratory syndrome virus Ab.Neut
    LP249856-8
    - Component Numerator Core
      Porcine reproductive and respiratory syndrome virus
      LP14277-5
    - Component Numerator Core Suffix
      Ab.Neut
      LP207365-0
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
Titr
LP6881-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser
LP7567-3
- System Core
  Ser
  LP7567-3
- Super System
  NULL
Scale
SemiQn
LP436123-6
Method
Neut
LP6416-4

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.46
Last Updated: Version 2.75 (MAJ)
Change Reason: Updated Component from "Porcine reproductive and respiratory syndrome virus Ab" since this test is measuring only the neutralizing antibodies and not all PRRSV antibodies.; Abbreviated "Porcine reproductive and respiratory syndrome virus" to "PRRSV" in the Long Common Name. PRRSV is shorter and more commonly used in test names.
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Virus reprodukčního a respiračního syndromu prasat (PRRS) Ab neutralizační:Arbitrární koncentrace (titr):Časový bod:Sérum:Semikvantitativní:Neutralizační test
el-GR	Greek (Greece)	Ιός του αναπαραγωγικού και αναπνευστικού συνδρόμου των χοίρων Ab.Neut:Titr:Pt:Ορός:Ημιποσοτική:Ουδετερόφιλα Synonyms: Ab.Neut MICRO Pt Titr Αντίσωμα Ημιποσοτική Ιός Ιός του αναπαραγωγικού και αναπνευστικού συνδρόμου των χοίρων Ορός Ουδετερόφιλα Των χοίρων
es-ES	Spanish (Spain)	virus del síndrome reproductivo y respiratorio porcino Anticuerpos antineutrófilos:Titulo / Factor de dilución:Punto temporal:Suero:Semicuantitativo:Prueba de neutralización Synonyms: Semicuantitativo
es-MX	Spanish (Mexico)	Virus del síndrome reproductivo y respiratorio porcino Ab.Neut:Título:Punto temporal:Suero:Cuantitativo:Prueba de neutralización
fr-CA	French (Canada)	Virus du syndrome respiratoire et reproductif porcin Ac.neut:Titre:Temps ponctuel:Sérum:SemiQn:Test de neutralisation
fr-FR	French (France)	Virus du syndrome dysgénésique et respiratoire porcin Ac neutralisant:Titre:Ponctuel:Sérum:Semi-Quantitatif:Neutralisation
it-IT	Italian (Italy)	Virus sindrome respiratoria e riproduttiva dei suini Ab.Neut:Titr:Pt:Siero:SemiQn:Neut Synonyms: anticorpo Microbiologia Punto nel tempo (episodio) Siero Test di neutralizzazione Titolo Virus PRRS
nl-NL	Dutch (Netherlands)	'porcine' reproductief en respiratoir syndroomvirus As.neutraliserend:titer:moment:serum:semikwantitatief:neutralisatietest Synonyms: antistof; antilichaam porcine voortplantings- en respiratoir syndroom virus van varken; PRRSV
pl-PL	Polish (Poland)	Wirus zespołu rozrodczo-oddechowego świń Ab.Neutralizujące:miano:punkt w czasie:surowica:półilościowy:test neutralizacji Synonyms: Przeciwciała neutralizujące do wirusa zespołu rozrodco-oddechowego świń
zh-CN	Chinese (China)	猪繁殖与呼吸综合征病毒抗体.中和:滴定度:时间点:血清:半定量型:中和试验 Synonyms: Ab;自身抗体 Lelystad 病毒;PRRS;SIRSV;兰耳病;新猪病;母猪后期流产;猪不育和呼吸综合症;猪不育和呼吸综合症（Swine infertility and respiratory syndrome，SIRSV）;猪生殖与呼吸系统综合症;猪生殖与呼吸综合症（Porcine reproductive and respiratory syndrome，PRRS）;猪繁殖与呼吸综合征;猪蓝耳病;猪蓝色病;神秘仔猪病;神秘猪病;莱利斯塔猪病毒（Lelystad Virus，LV）;蓝耳猪病;蓝耳病;蓝色流产症 SIRS Ab SIRSV 抗体中和试验;中和抗体;中和传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）效价;滴定浓度;滴定率;滴定量;滴度;稀释倍数;稀释因子;稀释系数时刻;随机;随意;瞬间猪的猪科猪科的猪繁殖与呼吸综合征病毒 Ab

Example Units

Unit	Source
{titer}	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.