74821-0
Chikungunya virus Ab [Presence] in Serum by Hemagglutination inhibition
Active
Part Descriptions
LP21132-3 Chikungunya virus
A species of ALPHAVIRUS causing an acute dengue-like fever.
Source: National Library of Medicine, MeSH 2006
LP21132-3 Chikungunya virus
Chikungunya virus (CHIKV) belongs to the mosquito-borne alphavirus genus, in the family Togaviridae, and was first observed in epidemic form in Africa. Serologically, CHIKV belongs to the Semliki Forest (SF) subgroup of alphaviruses. Infection in humans is characterized by rash, high fever and, its hallmark feature, severe arthritis that can persist for years. CHIKV is a small, spherical, enveloped, positive-strand RNA virus. The virion consists of an envelope and a nucleocapsid. The envelope glycoproteins of alphaviruses are the distinguishing factors for testing. The CHIKV genome encodes for two polyproteins; the non-structural polyprotein consisting of four proteins (nsP1, nsP2, nsP3 and nsP4) and the structural polyprotein consisting of five proteins (Capsid, E3, E2, 6K and E1). CHIKV has spikes on the virion surface that are each formed by three E1-E2 heterodimers, where the E1 glycoproteins mediate fusion and E2 glycoproteins interact with the host receptor. PMID: 20111039
CHIKV can be detected between the first and fourth day of infection (the acute phase) using PCR or virus cultivation, and virus-specific IgM and IgG antibodies can be detected during the 8th to the 10th day of infection. Antibody investigation should be performed using serum samples from the acute and convalescent stage.
Source: Regenstrief LOINC
LP6304-2 HAI
The hemagglutination-inhibition assay (HAI) can be used to identify subtypes of hemagglutinin producing viruses, such as Influenza. HAI can also be used to identify the subtype-specificity of antibodies against the virus. Normally, Influenza's hemagglutinin glycoprotein binds to receptors on the surface of red blood cells, causing them to agglutinate. If antibodies specific to the virus are present in the patient sample, they will bind to the virus, which prevents the virus from binding to the red blood cells and therefore prevents agglutination. To determine which subtype of virus is present, a viral isolate is tested against a series of antibodies with known subtype specificities. Whichever antibody inhibits red cell agglutination identifies the viral subtype. Similarly, antibody specificity is identified by testing the patient sample against known virus subtypes. PMID: 24899416
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Chikungunya virus Ab
- Property
- PrThr
- Time
- Pt
- System
- Ser
- Scale
- Ord
- Method
- HAI
Additional Names
- Short Name
- CHIKV Ab Ser Ql HAI
- Display Name
- CHIKV Ab HAI Ql (S)
- Consumer Name Alpha Get Info
- Chikungunya virus antibody, Blood
Example Answer List: LL360-9
Source: Regenstrief InstituteAnswer | Code | Score | Answer ID |
---|---|---|---|
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.48
- Last Updated
- Version 2.56
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
Member of these Groups Get Info
LOINC Group | Group Name |
---|---|
LG51028-5 | Chikungunya virus |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | Virus Chikungunya Anticuerpos: |
es-MX | Spanish (Mexico) | Virus de Chikungunya Ab: |
fr-CA | French (Canada) | Virus Chikungunya, Ac: |
fr-FR | French (France) | Chikungunya virus Ac: |
fr-BE | French (Belgium) | Virus Chikungunya Ac: Synonyms: Anticorps |
it-IT | Italian (Italy) | Chikungunya virus Ab: Synonyms: anticorpo CHIK Inibizione dell''emoagglutinazione Microbiologia Presenza o Soglia Punto nel tempo (episodio) Siero |
nl-NL | Dutch (Netherlands) | Chikungunya-virus As: Synonyms: antistof; |
pl-PL | Polish (Poland) | Wirus Chikungunya Ab: Synonyms: Przeciwciała do wirusa Chikungunya Wirus Chikungunya |
pt-BR | Portuguese (Brazil) | Chikungunya vírus Ac: |
tr-TR | Turkish (Turkey) | Chikungunya virus Ab: Synonyms: Ak Mevcut |
zh-CN | Chinese (China) | 基孔肯亚病毒 抗体: Synonyms: Ab; |
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- CodeSystem lookup
- https:
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Third Party Copyright
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LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright