Version 2.78

Part Descriptions

LP21132-3   Chikungunya virus
A species of ALPHAVIRUS causing an acute dengue-like fever. Source: National Library of Medicine, MeSH 2006

LP21132-3   Chikungunya virus
Chikungunya virus (CHIKV) belongs to the mosquito-borne alphavirus genus, in the family Togaviridae, and was first observed in epidemic form in Africa. Serologically, CHIKV belongs to the Semliki Forest (SF) subgroup of alphaviruses. Infection in humans is characterized by rash, high fever and, its hallmark feature, severe arthritis that can persist for years. CHIKV is a small, spherical, enveloped, positive-strand RNA virus. The virion consists of an envelope and a nucleocapsid. The envelope glycoproteins of alphaviruses are the distinguishing factors for testing. The CHIKV genome encodes for two polyproteins; the non-structural polyprotein consisting of four proteins (nsP1, nsP2, nsP3 and nsP4) and the structural polyprotein consisting of five proteins (Capsid, E3, E2, 6K and E1). CHIKV has spikes on the virion surface that are each formed by three E1-E2 heterodimers, where the E1 glycoproteins mediate fusion and E2 glycoproteins interact with the host receptor. PMID: 20111039
CHIKV can be detected between the first and fourth day of infection (the acute phase) using PCR or virus cultivation, and virus-specific IgM and IgG antibodies can be detected during the 8th to the 10th day of infection. Antibody investigation should be performed using serum samples from the acute and convalescent stage. Source: Regenstrief LOINC

LP6304-2   HAI
The hemagglutination-inhibition assay (HAI) can be used to identify subtypes of hemagglutinin producing viruses, such as Influenza. HAI can also be used to identify the subtype-specificity of antibodies against the virus. Normally, Influenza's hemagglutinin glycoprotein binds to receptors on the surface of red blood cells, causing them to agglutinate. If antibodies specific to the virus are present in the patient sample, they will bind to the virus, which prevents the virus from binding to the red blood cells and therefore prevents agglutination. To determine which subtype of virus is present, a viral isolate is tested against a series of antibodies with known subtype specificities. Whichever antibody inhibits red cell agglutination identifies the viral subtype. Similarly, antibody specificity is identified by testing the patient sample against known virus subtypes. PMID: 24899416 Source: Regenstrief LOINC

Fully-Specified Name

Component
Chikungunya virus Ab
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
HAI

Additional Names

Short Name
CHIKV Ab Ser Ql HAI
Display Name
CHIKV Ab HAI Ql (S)
Consumer Name Alpha Get Info
Chikungunya virus antibody, Blood

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.48
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG51028-5 Chikungunya virus

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Virus Chikungunya Anticuerpos:PrThr:Punto temporal:Suero:Ord:Inhibición de la Hemaglutinación
es-MX Spanish (Mexico) Virus de Chikungunya Ab:Presencia o umbral:Punto temporal:Suero:Ordinal:Inhibición de la hemaglutinación
fr-CA French (Canada) Virus Chikungunya, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Inhibition de l'hémagglutination
fr-FR French (France) Chikungunya virus Ac:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Hémagglutination indirecte
fr-BE French (Belgium) Virus Chikungunya Ac:PrThr:Temps ponctuel:Sérum:Ordinal:Inhibition de l'hémagglutination
Synonyms: Anticorps
it-IT Italian (Italy) Chikungunya virus Ab:PrThr:Pt:Siero:Ord:HAI
Synonyms: anticorpo CHIK Inibizione dell''emoagglutinazione Microbiologia Presenza o Soglia Punto nel tempo (episodio) Siero
nl-NL Dutch (Netherlands) Chikungunya-virus As:aanwezigheid:moment:serum:ordinaal:hemagglutinatieremming
Synonyms: antistof; antilichaam
pl-PL Polish (Poland) Wirus Chikungunya Ab:granica wykrywalności:punkt w czasie:surowica:półilościowy:hamowanie hemaglutynacji
Synonyms: Przeciwciała do wirusa Chikungunya Wirus Chikungunya
pt-BR Portuguese (Brazil) Chikungunya vírus Ac:Limiar:Pt:Soro:Ord:Hemaglutinação indireta
tr-TR Turkish (Turkey) Chikungunya virus Ab:MevcEşik:Zmlı:Ser:Srl:HAI
Synonyms: Ak Mevcut
zh-CN Chinese (China) 基孔肯亚病毒 抗体:存在情况或阈值:时间点:血清:序数型:红细胞凝集抑制试验法
Synonyms: Ab;自身抗体 CHIKV Ab CHIKV 抗体 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 依次型;分类顺序型;定性的;序数型(或称等级型);性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 基孔肯亚病毒 Ab 基孔肯雅病毒 Ab 基孔肯雅病毒抗体 奇昆古尼亚病毒;基孔肯雅病毒;CHIKV 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况(存在、存在与否、是否存在)或阈值(界值、界限、阀值、临界值) 微生物学;微生物学试验;微生物学试验(培养、DNA、抗原及抗体) 时刻;随机;随意;瞬间 红细胞凝集抑制试验

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