74821-0

Chikungunya virus Ab [Presence] in Serum by Hemagglutination inhibition

Active

Part Descriptions

LP21132-3 Chikungunya virus
A species of ALPHAVIRUS causing an acute dengue-like fever. Source: National Library of Medicine, MeSH 2006

LP21132-3 Chikungunya virus
Chikungunya virus (CHIKV) belongs to the mosquito-borne alphavirus genus, in the family Togaviridae, and was first observed in epidemic form in Africa. Serologically, CHIKV belongs to the Semliki Forest (SF) subgroup of alphaviruses. Infection in humans is characterized by rash, high fever and, its hallmark feature, severe arthritis that can persist for years. CHIKV is a small, spherical, enveloped, positive-strand RNA virus. The virion consists of an envelope and a nucleocapsid. The envelope glycoproteins of alphaviruses are the distinguishing factors for testing. The CHIKV genome encodes for two polyproteins; the non-structural polyprotein consisting of four proteins (nsP1, nsP2, nsP3 and nsP4) and the structural polyprotein consisting of five proteins (Capsid, E3, E2, 6K and E1). CHIKV has spikes on the virion surface that are each formed by three E1-E2 heterodimers, where the E1 glycoproteins mediate fusion and E2 glycoproteins interact with the host receptor. PMID: 20111039
CHIKV can be detected between the first and fourth day of infection (the acute phase) using PCR or virus cultivation, and virus-specific IgM and IgG antibodies can be detected during the 8th to the 10th day of infection. Antibody investigation should be performed using serum samples from the acute and convalescent stage. Source: Regenstrief LOINC

LP6304-2 HAI
The hemagglutination-inhibition assay (HAI) can be used to identify subtypes of hemagglutinin producing viruses, such as Influenza. HAI can also be used to identify the subtype-specificity of antibodies against the virus. Normally, Influenza's hemagglutinin glycoprotein binds to receptors on the surface of red blood cells, causing them to agglutinate. If antibodies specific to the virus are present in the patient sample, they will bind to the virus, which prevents the virus from binding to the red blood cells and therefore prevents agglutination. To determine which subtype of virus is present, a viral isolate is tested against a series of antibodies with known subtype specificities. Whichever antibody inhibits red cell agglutination identifies the viral subtype. Similarly, antibody specificity is identified by testing the patient sample against known virus subtypes. PMID: 24899416 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Chikungunya virus Ab:PrThr:Pt:Ser:Ord:HAI
Long Common Name: Chikungunya virus Ab [Presence] in Serum by Hemagglutination inhibition
Short Name: CHIKV Ab Ser Ql HAI
Display Name: CHIKV Ab HAI Ql (S)
Consumer Name Alpha Get Info: Chikungunya virus antibody, Blood

Part Model Get Info

Component
Chikungunya virus Ab
LP37605-0
- Analyte
  Chikungunya virus Ab
  LP37605-0
  - Component Numerator
    Chikungunya virus Ab
    LP37605-0
    - Component Numerator Core
      Chikungunya virus
      LP21132-3
    - Component Numerator Core Suffix
      Ab
      LP20667-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser
LP7567-3
- System Core
  Ser
  LP7567-3
- Super System
  NULL
Scale
Ord
LP7751-3
Method
HAI
LP6304-2

Example Answer List: LL360-9

Source: Regenstrief Institute

Answer	Code	Score	Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.48
Last Updated: Version 2.56 (MIN)
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both

Member of these Groups Get Info

LOINC Group	Group Name
LG51028-5	Chikungunya virus

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Virus Chikungunya Ab:Přítomnost nebo práh:Časový bod:Sérum:Ordinální:Inhibice hemaglutinace
el-GR	Greek (Greece)	Ιός Chikungunya Αντίσωμα:PrThr:Pt:Ορός:Ord:HAI Synonyms: HAI MICRO Ord PrThr Pt Αντίσωμα Ιός Ιός Chikungunya Ορός
es-ES	Spanish (Spain)	Virus Chikungunya Anticuerpos:PrThr:Punto temporal:Suero:Ord:Inhibición de la Hemaglutinación
es-MX	Spanish (Mexico)	Virus de Chikungunya Ab:Presencia o umbral:Punto temporal:Suero:Ordinal:Inhibición de la hemaglutinación
fr-CA	French (Canada)	Virus Chikungunya, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Inhibition de l'hémagglutination
fr-FR	French (France)	Chikungunya virus Ac:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Hémagglutination indirecte
fr-BE	French (Belgium)	Virus Chikungunya Ac:PrThr:Temps ponctuel:Sérum:Ordinal:Inhibition de l'hémagglutination Synonyms: Anticorps
it-IT	Italian (Italy)	Chikungunya virus Ab:PrThr:Pt:Siero:Ord:HAI Synonyms: anticorpo CHIK Inibizione dell''emoagglutinazione Microbiologia Presenza o Soglia Punto nel tempo (episodio) Siero
nl-NL	Dutch (Netherlands)	Chikungunya-virus As:aanwezigheid:moment:serum:ordinaal:hemagglutinatieremming Synonyms: antistof; antilichaam
pl-PL	Polish (Poland)	Wirus Chikungunya Ab:granica wykrywalności:punkt w czasie:surowica:uporządkowany:hamowanie hemaglutynacji Synonyms: Przeciwciała do wirusa Chikungunya Wirus Chikungunya
pt-BR	Portuguese (Brazil)	Chikungunya vírus Ac:Limiar:Pt:Soro:Ord:Hemaglutinação indireta
tr-TR	Turkish (Turkey)	Chikungunya virus Ab:MevcEşik:Zmlı:Ser:Srl:HAI Synonyms: Ak Mevcut
zh-CN	Chinese (China)	基孔肯亚病毒抗体:存在情况或阈值:时间点:血清:序数型:红细胞凝集抑制试验法 Synonyms: Ab;自身抗体 CHIKV Ab CHIKV 抗体传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型基孔肯亚病毒 Ab 基孔肯雅病毒 Ab 基孔肯雅病毒抗体奇昆古尼亚病毒;基孔肯雅病毒;CHIKV 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）时刻;随机;随意;瞬间红细胞凝集抑制试验

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.