LOINC
Version 2.73

74828-5Snowshoe hare virus neutralizing antibody [Presence] in Serum by Neutralization testActive

Part Descriptions

LP21136-4   Snowshoe hare virus
A member of the California group of arboviruses (family bunyaviridae) causing fever, severe headache, and nausea in humans in North America. Copyright Copyright © Biology-Online.org. All Rights Reserved. Source: Biology Online, Snowshoe hare virus

LP6416-4   Neut
In LOINC, the Method "Neut" represents the virus neutralization test (VNT), also called conventional VNT, which is a specific laboratory method that is used primarily for identifying whether neutralizing antibodies for the virus of interest are present in the patient sample. The VNT involves incubating patient serum with the virus of interest, and then inoculating onto cell culture. If neutralizing antibodies are present and the virus is neutralized, the cells will not be infected. If neutralizing antibodies are not present, the virus will infect the cells in the cell culture. [PMID:32170698] This method can also be used to identify specific virus serotypes or strains, by performing separate tests in which serum is incubated with each of the specific virus serotypes or strains of interest. [PMID:169804] Source: Regenstrief LOINC

LP207365-0   Ab.Neut
Neutralizing antibodies are antibodies that interfere with the interaction between the virus and its host cell receptor, therefore preventing infectivity. Neutralizing antibodies can be detected using a traditional VNT or other methods such as pseudovirus VNT and surrogate VNT. VNT and pseudovirus VNT use live virus (the actual virus or a recombinant virus that incorporates the viral antigen of interest, respectively) and cell culture to assess the virus-host interaction and whether neutralizing antibodies are present that block that interaction. Surrogate VNT (sVNT) does not use live virus but rather uses purified viral antigen and host cell receptor protein to mimic the same interaction. The sVNT method is currently (2021) represented in LOINC as IA, because it is an immunoassay-based method. Source: Regenstrief LOINC

Fully-Specified Name

Component
Snowshoe hare virus Ab.Neut
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
Neut

Additional Names

Short Name
SSHV NAb Ser Ql Nt
Display Name
Snowshoe hare virus neut ab Neut test Ql (S)
Consumer Name Alpha
Snowshoe Hare virus neutralizing antibody, Blood

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.48
Last Updated
Version 2.72
Change Reason
Release 2.72: COMPONENT: Updated "Ab" to "Ab.Neut" since this test is detecting neutralizing antibodies.; Previous Releases: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Language Variants Get Info

zh-CNChinese (China)
雪鞋野兔病毒 抗体.中和:存在情况或阈值:时间点:血清:序数型:中和试验
nl-NLDutch (Netherlands)
Snowshoe hare-virus As.neutraliserend:aanwezigheid:moment:serum:ordinaal:neutralisatietest
fr-CAFrench (Canada)
Virus lièvre américain Ac.neut:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Test de neutralisation
fr-FRFrench (France)
Virus du lièvre des neiges Ac:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Neutralisation
it-ITItalian (Italy)
Lepre scarpa da neve, virus Ab.Neut:PrThr:Pt:Siero:Ord:Neut
pt-BRPortuguese (Brazil)
Lebre Snowshoe vírus Ac:Limiar:Pt:Soro:Ord:
es-MXSpanish (Mexico)
Virus de la liebre de raquetas de nieve Ab:Presencia o umbral:Punto temporal:Suero:Ordinal:Prueba de neutralización
es-ESSpanish (Spain)
Virus de la liebre de requeta Anticuerpos antineutrófilos:PrThr:Punto temporal:Suero:Ord:Prueba de neutralización

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=74828-5