74835-0
Porphyrin fractions panel - Stool
Active
75024-0 Coproporphyrin 1/Porphyrins.total in Stool
Part Descriptions
LP18633-5 Coproporphyrin 1
Coproporhyrin I is a porphyrin metabolite arising from heme synthesis. Porphyrins are pigments found in both animal and plant life. Coproporphyrin I is a tetrapyrrole dead-end product from the spontaneous oxidation of the methylene bridges of coproporphynogen, arising from heme synthesis and secreted in feces and urine. Increased levels of coproporphyrins can indicate congenital erythropoietic porphyria or sideroblastic anaemia. Porphyria is a pathological state characterised by abnormalities of porphyrin metabolism and results in the excretion of large quantities of porphyrins in the urine and in extreme sensitivity to light. A large number of factors are capable of increasing porphyrin excretion, owing to different and multiple causes and etiologies: 1) the main site of the chronic hepatic porphyria disease process concentrates on the liver, 2) a functional and morphologic liver injury is almost regularly associated with this chronic porphyria, 3) the toxic form due to occupational and environmental exposure takes mainly a subclinical course. Hepatic factors includes disturbance in coproporphyrinogen metabolism, which results from inhibition of coproporphyrinogen oxidase as well as from the rapid loss from, and diminished utilization of coproporphyrinogen in the hepatocytes, which may also explain why coproporphyrin, its autoxidation product, predominates physiologically in the urine; decreased biliary excretion of coproporphyrin leading to a compensatory urinary excretion, so that the coproporphyrin ring isomer ratio (1:III) becomes a sensitive index for impaired liver function and intrahepatic cholestasis; and disturbed activity of hepatic uroporphyrinogen decarboxylase. In itself, secondary coproporphyrinuria is not associated with porphyria symptoms of a hepatologic-gastroenterologic, neurologic, or dermatologic order, even though coproporphyrinuria can occur with such symptoms. PMID: 3327428
Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.)
Source: Human Metabolome Database, Corproporphyrin I
Fully-Specified Name
- Component
- Coproporphyrin 1/Porphyrins.total
- Property
- SFr
- Time
- Pt
- System
- Stool
- Scale
- Qn
- Method
Additional Names
- Short Name
- Copro1 SFr Stl
- Display Name
- Coproporphyrin 1/Total porphyrins (Stl) [Molar fraction]
- Consumer Name Alpha Get Info
- Coproporphyrin 1/Total Porphyrins, Stool
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.48
- Last Updated
- Version 2.48
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 74835-0 | Porphyrin fractions panel - Stool |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Coproporfirina 1/Niveles totales de porfirinas: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Coproporfirina 1 / Porfirinas total: |
| et-EE | Estonian (Estonia) | Koproporfüriin 1/porfüriinid.üld: Synonyms: Aine fraktsioon Juhuslik Kvantitatiivne Roe |
| fr-FR | French (France) | Coproporphyrine 1/porphyrines totales: |
| fr-BE | French (Belgium) | Coproporphyrine 1/Porphyrines.totales: Synonyms: Fraction. Concentration |
| fr-CA | French (Canada) | Coproporphyrine 1/Porphyrines.totales: |
| it-IT | Italian (Italy) | Coproporfirina 1/Porfirine.totali: Synonyms: Chimica Frazione di Sostanza Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | coproporfyrine 1/porfyrinen.totaal: Synonyms: ontlasting; |
| pt-BR | Portuguese (Brazil) | Coproporfirina 1/Porfirinas.total: |
| ru-RU | Russian (Russian Federation) | Копропорфирин 1/Порфирины.общий: Synonyms: Количественный Мольная доля; |
| tr-TR | Turkish (Turkey) | Koproporfirin 1/Porfirinler.total: Synonyms: Gaita; |
| zh-CN | Chinese (China) | 粪卟啉 I/卟啉.总计: Synonyms: Ⅰ Copro; |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
75025-7 Coproporphyrin 3/Porphyrins.total in Stool
Term Description
Total fecal porphyrins are markedly increased especially in active HCP (Hereditary Coproporphyria) and VP (Variegate Porphyria) and to a lesser extent in PCT (Porphyria Cutanea Tarda) and EPP (Erythropoietic Protoporphyria). Fecal porphyrins can be separated and measured individually by HPLC. Porphyrins with 2-4 carboxyl groups generally predominate in feces. These are excreted by the liver into the bile and then flow into the intestine. As with urine, it is most useful to measure the total amount of porphyrins in a fecal sample. If this is increased, then the laboratory should determine which porphyrins predominate rather than focus on the amount of each porphyrin. Fecal porphyrin determinations may be confounded by variations in fecal flow; most people have one or a few bowel movements daily and a "24 hour stool collection" is really not uniform from day to day. Substances in the diet and any internal bleeding into the stomach or intestines may also interfere.
Source: Regenstrief LOINC
Part Descriptions
LP14372-4 Coproporphyrin 3
Coproporhyrin III is a porphyrin metabolite arising from heme synthesis. Porphyrins are pigments found in both animal and plant life. Coproporphyrin III is a tetrapyrrole dead-end product from the spontaneous oxidation of the methylene bridges of coproporphynogen, arising from heme synthesis and secreted in feces and urine. Increased levels of coproporphyrins can indicate congenital erythropoietic porphyria or sideroblastic anaemia. Porphyria is a pathological state characterised by abnormalities of porphyrin metabolism and results in the excretion of large quantities of porphyrins in the urine and in extreme sensitivity to light. A large number of factors are capable of increasing porphyrin excretion, owing to different and multiple causes and etiologies: 1) the main site of the chronic hepatic porphyria disease process concentrates on the liver, 2) a functional and morphologic liver injury is almost regularly associated with this chronic porphyria, 3) the toxic form due to occupational and environmental exposure takes mainly a subclinical course. Hepatic factors includes disturbance in coproporphyrinogen metabolism, which results from inhibition of coproporphyrinogen oxidase as well as from the rapid loss from, and diminished utilization of coproporphyrinogen in the hepatocytes, which may also explain why coproporphyrin, its autoxidation product, predominates physiologically in the urine; decreased biliary excretion of coproporphyrin leading to a compensatory urinary excretion, so that the coproporphyrin ring isomer ratio (1:III) becomes a sensitive index for impaired liver function and intrahepatic cholestasis; and disturbed activity of hepatic uroporphyrinogen decarboxylase. In itself, secondary coproporphyrinuria is not associated with porphyria symptoms of a hepatologic-gastroenterologic, neurologic, or dermatologic order, even though coproporphyrinuria can occur with such symptoms. PMID: 3327428
Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.)
Source: Human Metabolome Database, Corproporphyrin III
Fully-Specified Name
- Component
- Coproporphyrin 3/Porphyrins.total
- Property
- SFr
- Time
- Pt
- System
- Stool
- Scale
- Qn
- Method
Additional Names
- Short Name
- Copro3 SFr Stl
- Display Name
- Coproporphyrin 3/Total porphyrins (Stl) [Molar fraction]
- Consumer Name Alpha Get Info
- Coproporphyrin 3/Total Porphyrins, Stool
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.48
- Last Updated
- Version 2.48
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 74835-0 | Porphyrin fractions panel - Stool |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Coproporfirina 3/Niveles totales de porfirinas: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Coproporfirina 3 / Porfirinas total: |
| et-EE | Estonian (Estonia) | Koproporfüriin 3/porfüriinid.üld: Synonyms: Aine fraktsioon Juhuslik Kvantitatiivne Roe |
| fr-FR | French (France) | Coproporphyrine 3/porphyrines totales: |
| fr-BE | French (Belgium) | Coproporphyrine 3/Porphyrines.totales: Synonyms: Fraction. Concentration |
| fr-CA | French (Canada) | Coproporphyrine 3/Porphyrines.totales: |
| it-IT | Italian (Italy) | Coproporfirina 3/Porfirine.totali: Synonyms: Chimica Frazione di Sostanza Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | coproporfyrine 3/porfyrinen.totaal: Synonyms: ontlasting; |
| pt-BR | Portuguese (Brazil) | Coproporfirina 1/Porfirinas.total: |
| ru-RU | Russian (Russian Federation) | Копропорфирин 3/Порфирины.общий: Synonyms: Количественный Мольная доля; |
| tr-TR | Turkish (Turkey) | Koproporfirin 3/Porfirinler.total: Synonyms: Gaita; |
| zh-CN | Chinese (China) | 粪卟啉 III/卟啉.总计: Synonyms: Ⅲ Copro; |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
75026-5 Deuteroporphyrin/Porphyrins.total in Stool
Part Descriptions
LP14345-0 Deuteroporphyrin
Some intestinal bacteria produce deuteroporphyrin which contribute significantly to total fecal porphyrin levels.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Deuteroporphyrin/Porphyrins.total
- Property
- SFr
- Time
- Pt
- System
- Stool
- Scale
- Qn
- Method
Additional Names
- Short Name
- Deuteropor SFr Stl
- Display Name
- Deuteroporphyrin/Total porphyrins (Stl) [Molar fraction]
- Consumer Name Alpha Get Info
- Deuteroporphyrin/Total Porphyrins, Stool
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.48
- Last Updated
- Version 2.48
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 74835-0 | Porphyrin fractions panel - Stool |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Deuteroporfirina/Niveles totales de porfirinas: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Deuteroporfirina / Porfirinas total: |
| fr-FR | French (France) | Deutéroporphyrine/porphyrines totales: |
| fr-BE | French (Belgium) | Deutéroporphyrine/Porphyrines.totales: Synonyms: Fraction. Concentration |
| fr-CA | French (Canada) | Deutéroporphyrine/Porphyrines.totales: |
| it-IT | Italian (Italy) | Deuteroporfirina/Porfirine.totali: Synonyms: Chimica Frazione di Sostanza Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | deuteroporfyrine/porfyrinen.totaal: Synonyms: ontlasting; |
| pt-BR | Portuguese (Brazil) | Deuteroporfirina/Porfirinas.total: |
| ru-RU | Russian (Russian Federation) | Дейтеропорфирин/Порфирины.общий: Synonyms: Количественный Мольная доля; |
| tr-TR | Turkish (Turkey) | Döteroporfirin/Porfirinler.total: Synonyms: Gaita; |
| zh-CN | Chinese (China) | 次卟啉/卟啉.总计: Synonyms: Porph; |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
75027-3 Mesoporphyrin/Porphyrins.total in Stool
Part Descriptions
LP18646-7 Mesoporphyrin
Mesoporphyrin is produced by gastrointestinal bacteria and contributes to total fecal porphyrin levels.
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Mesoporphyrin/Porphyrins.total
- Property
- SFr
- Time
- Pt
- System
- Stool
- Scale
- Qn
- Method
Additional Names
- Short Name
- Mesopor SFr Stl
- Display Name
- Mesoporphyrin/Total porphyrins (Stl) [Molar fraction]
- Consumer Name Alpha Get Info
- Mesoporphyrin/Total Porphyrins, Stool
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.48
- Last Updated
- Version 2.48
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 74835-0 | Porphyrin fractions panel - Stool |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Mesoporfirina/Niveles totales de porfirinas: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Mesoporfirina / Porfirinas total: |
| et-EE | Estonian (Estonia) | Mesoporfüriin/porfüriinid.üld: Synonyms: Aine fraktsioon Juhuslik Kvantitatiivne Roe |
| fr-FR | French (France) | Mésoporphyrine/porphyrines totales: |
| fr-BE | French (Belgium) | Mésoporphyrine/Porphyrines.totales: Synonyms: Fraction. Concentration |
| fr-CA | French (Canada) | Mésoporphyrine/Porphyrines.totales: |
| it-IT | Italian (Italy) | Mesoporfirina/Porfirine.totali: Synonyms: Chimica Frazione di Sostanza Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | mesoporfyrine/porfyrinen.totaal: Synonyms: ontlasting; |
| pt-BR | Portuguese (Brazil) | Mesoporfirina/Porfirinas.total: |
| ru-RU | Russian (Russian Federation) | Мезопорфирин/Порфирины.общий: Synonyms: Количественный Мольная доля; |
| tr-TR | Turkish (Turkey) | Mesoporfirin/Porfirinler.total: Synonyms: Gaita; |
| zh-CN | Chinese (China) | 中卟啉/卟啉.总计: Synonyms: Mesopor; |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
75028-1 Protoporphyrin/Porphyrins.total in Stool
Part Descriptions
LP15839-1 Protoporphyrin
Protoporphyrins are tetrapyrroles containing the following side chains:methyl (4)propionic acid (2)vinyl (2)In the metabolism of porphyrin, protoporphyrin IX is created by the enzyme protoporphyrinogen oxidase, and the enzyme ferrochelatase converts it into heme. Protoporphyrins are deposited in the shells of the eggs of some birds as a brown or red pigment, either as a ground color or as spotting. This occurs in most passerine species, some ground-nesting non-passerines, such as waders, gulls, nightjars and sandgrouse, where it provides camouflage, and some parasitic cuckoos, which need to mimic their passerine hosts' eggs. Protoporphyrins strengthen the egg shell, and are deposited where the shell is too thin as a result of calcium shortage. Spotting therefore tend to be heavier where the local soil is calcium-deficient, and in the eggs laid last in a clutch.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, Protoporphyrin (Wikipedia)
LP15839-1 Protoporphyrin
2 carboxyl groups
Source: Regenstrief Institute
LP15839-1 Protoporphyrin
Porphyrins increased in lead poisoning, exposure to certain drugs and chemical, tyrosinemia, secondary polycythemia, liver disease, thalassemia, oral contraceptive use and chronic inflammation.
Source: Regenstrief Institute
Fully-Specified Name
- Component
- Protoporphyrin/Porphyrins.total
- Property
- SFr
- Time
- Pt
- System
- Stool
- Scale
- Qn
- Method
Additional Names
- Short Name
- Protopor SFr Stl
- Display Name
- Protoporphyrin/Total porphyrins (Stl) [Molar fraction]
- Consumer Name Alpha Get Info
- Protoporphyrin/Total Porphyrins, Stool
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.48
- Last Updated
- Version 2.48
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 74835-0 | Porphyrin fractions panel - Stool |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-MX | Spanish (Mexico) | Protoporfirina / Porfirinas total: |
| es-ES | Spanish (Spain) | Protoporfirina/Niveles totales de porfirinas: Synonyms: Cuantitativo |
| et-EE | Estonian (Estonia) | Protoporfüriin/porfüriinid.üld: Synonyms: Aine fraktsioon Juhuslik Kvantitatiivne Roe |
| fr-BE | French (Belgium) | Protoporphyrines/Porphyrines.totales: Synonyms: Fraction. Concentration |
| fr-FR | French (France) | Protoporphyrine/porphyrines totales: |
| fr-CA | French (Canada) | Protoporphyrine/Porphyrines.totales: |
| it-IT | Italian (Italy) | Protoporfirina/Porfirine.totali: Synonyms: Chimica Frazione di Sostanza Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | protoporfyrine/porfyrinen.totaal: Synonyms: ontlasting; |
| pt-BR | Portuguese (Brazil) | Protoporfirina/Porfirinas.total: |
| ru-RU | Russian (Russian Federation) | Протопорфирин/Порфирины.общий: Synonyms: Количественный Мольная доля; |
| tr-TR | Turkish (Turkey) | Protoporfirin/Porfirinler.total: Synonyms: Gaita; |
| zh-CN | Chinese (China) | 原卟啉/卟啉.总计: Synonyms: Porph; |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
49290-0 Porphyrins [Interpretation] in Stool Narrative
Part Descriptions
LP14913-5 Porphyrins
A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.
Source: National Library of Medicine, MeSH 2006
LP14913-5 Porphyrins
Porphyrins are created as byproducts of porphyrinogens. Hereditary enzyme disorders leading to the buildup of porphyrins or porphyrinogens cause porphyrias and affect the heme biosynthetic pathway. Most of these disorders are inherited as autosomal dominant disorders. Increased urine porphyrins are seen with congenital erythropoietic porphyria, acute intermittent porphyria, hereditary coproporphyria, variegate porphyria, and porphyria cutanea tarda. Information from LOINC partner 1 and Jacobs and DeMott Laboratory Test Handbook, 5th edition, DS Jacobs, WR DeMott and DK Oxley, 2001.
Source: Regenstrief Institute
Fully-Specified Name
- Component
- Porphyrins
- Property
- Imp
- Time
- Pt
- System
- Stool
- Scale
- Nar
- Method
Additional Names
- Short Name
- Porphyrins Stl-Imp
- Display Name
- Porphyrins Nar (Stl) [Interp]
- Consumer Name Alpha Get Info
- Interpretation of Porphyrins test result, Stool
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.21
- Last Updated
- Version 2.21
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 74835-0 | Porphyrin fractions panel - Stool |
| 74445-8 | Porphyrin fractions panel [Moles/mass] - Stool |
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG2674-2 | Porphyrins| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-DE | German (Germany) | Porphyrine: |
| es-ES | Spanish (Spain) | Porfirinas y relacionados: |
| es-MX | Spanish (Mexico) | Porfirinas: |
| fr-FR | French (France) | Porphyrines: |
| fr-BE | French (Belgium) | Porphyrines: |
| fr-CA | French (Canada) | Porphyrines: |
| it-IT | Italian (Italy) | Porfirine: Synonyms: Chimica Impressione/interpretazione di studio Punto nel tempo (episodio) |
| nl-NL | Dutch (Netherlands) | porfyrinen: Synonyms: ontlasting; |
| pt-BR | Portuguese (Brazil) | Porfirinas: Synonyms: Porph; |
| ru-RU | Russian (Russian Federation) | Порфирины: Synonyms: Впечатление/интерпретация исследования Описательный Точка во времени; |
| tr-TR | Turkish (Turkey) | Porfirinler: Synonyms: Gaita; |
| zh-CN | Chinese (China) | 卟啉类: Synonyms: Porph; |