t(15;17)(q24.1;q21.1)(PML,RARA) fusion transcript [Presence] in Bone marrow by Molecular genetics method
The fusion of promyelocytic leukemia (PML, chromosome 15q24.1) and retinoic acid receptor alpha (RARA, chromosome 17q21.1) genes occurs due to a chromosomal translocation. The fused genes can be detected by various molecular techniques, including FISH and real-time quantitative polymerase chain reaction (RT-qPCR). The test is used to diagnose Acute Promyelocytic Leukemia (APL), detect residual or recurrent APL, and to monitor PML-RARA levels in patients with APL. The assay can be done on whole blood (plasma or cell-based) and bone marrow. Long, variant and/or short isoforms of PML-RARA fusion transcripts may be identified. The ratio of PML-RARA fusion transcript to a control gene (e.g. ABL1) may be reported for positive samples. Source: Regenstrief LOINC
- t(15;17)(q24.1;q21.1)(PML,RARA) fusion transcript
- Bone mar
- Short Name
- t(15;17)(PML,RARA) Mar Ql
- Display Name
- t(15;17)(q24.1;q21.1)(PML,RARA) fusion transcript Molgen Ql (BM)
- Consumer Name Alpha
- t(15;17)(q24.1;q21.1)(PML,RARA) fusion transcript analysis, Bone marrow
Example Answer List: LL360-9Source: Regenstrief Institute
|PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)||LA6576-8|
|NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)||LA6577-6|
- First Released
- Version 2.48
- Last Updated
- Version 2.56
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
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