LOINC
Version 2.67

75011-7t(15;17)(q24.1;q21.1)(PML,RARA) fusion transcript [Presence] in Bone marrow by Molecular genetics methodActive

Part Description

LP150268-3   t(15;17)(q24.1;q21.1)(PML,RARA)
The fusion of promyelocytic leukemia (PML, chromosome 15q24.1) and retinoic acid receptor alpha (RARA, chromosome 17q21.1) genes occurs due to a chromosomal translocation. The fused genes can be detected by various molecular techniques, including FISH and real-time quantitative polymerase chain reaction (RT-qPCR). The test is used to diagnose Acute Promyelocytic Leukemia (APL), detect residual or recurrent APL, and to monitor PML-RARA levels in patients with APL. The assay can be done on whole blood (plasma or cell-based) and bone marrow. Long, variant and/or short isoforms of PML-RARA fusion transcripts may be identified. The ratio of PML-RARA fusion transcript to a control gene (e.g. ABL1) may be reported for positive samples. Source: Regenstrief LOINC

Fully-Specified Name

Component
t(15;17)(q24.1;q21.1)(PML,RARA) fusion transcript
Property
PrThr
Time
Pt
System
Bone mar
Scale
Ord
Method
Molgen

Additional Names

Short Name
t(15;17)(PML,RARA) Mar Ql
Display Name
t(15;17)(q24.1;q21.1)(PML,RARA) fusion transcript Molgen Ql (BM)

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.48
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
t(15;17)(q24.1;q21.1)(PML,RARA) 融合转录物:存在情况或阈值:时间点:骨髓:序数型:分子遗传学类实验室方法
nl-NLDutch (NETHERLANDS)
t(15;17)(q24.1;q21.1)(PML,RARA) fusietranscript:aanwezigheid:moment:beenmerg:ordinaal:moleculair genetisch onderzoek
fr-CAFrench (CANADA)
t(15;17)(q24.1;q21.1)(PML,RARA) , transcrit de fusion:Présence-Seuil:Temps ponctuel:Moelle osseuse:Ordinal:Molgen
fr-FRFrench (FRANCE)
t(15;17)(q24.1;q21.1)(PML,RARA) transcrit de fusion:Présence/Seuil:Ponctuel:Moelle osseuse:Qualitatif:Biologie moléculaire
it-ITItalian (ITALY)
t(15;17)(q24.1;q21.1)(PML,RARA) , trascritto di fusione:PrThr:Pt:Mid oss:Ord:Molgen
pt-BRPortuguese (BRAZIL)
ru-RURussian (RUSSIAN FEDERATION)
t(15;17)(q24.1;q21.1)(PML,RARA) слияния транскрипт:PrThr:ТчкВрм:Костный мозг:Пор:МолГен
es-ESSpanish (SPAIN)
t(15;17)(q24.1;q21.1)(PML,RARA) Tránscritos de fusión:PrThr:Punto temporal:Médula ósea:Ord:Genética molecular
tr-TRTurkish (TURKEY)
t(15;17)(q24.1;q21.1)(PML,RARA) füzyon transkript:MevcEşik:Zmlı:Kem il:Srl:Molgen

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=75011-7