Version 2.80

Term Description

Analysis of the Bruton tyrosine kinase (Btk) protein by flow cytometry is performed as a preliminary screen for X-linked agammaglobulinemia (XLA), primarily in male patients (<65 years of age) or female carriers (child-bearing age: <45 years). Since genotype-phenotype correlations are important, BTK gene sequencing [LOINC: 35295-5] is performed when the Btk protein is absent by flow cytometry to confirm the diagnosis of XLA.

Part Description

LP185945-5   Bruton tyrosine kinase
Bruton tyrosine kinase (Btk) is an intracellular protein that plays a crucial role in B-cell development. Mutations in the BTK gene are known to cause primary immunodeficiency disease X-linked agammaglobulinemia (XLA, Bruton's agammaglobulinemia). Approximately 20% to 30% of XLA patients may have intact or truncated Btk protein with abnormal function. Therefore, gene mutation analysis by sequencing or other methods is more definitive for diagnosing XLA. Source: Regenstrief LOINC

Fully-Specified Name

Component
Bruton tyrosine kinase
Property
Imp
Time
Pt
System
B cells+monocytes
Scale
Nar
Method
Flow cytometry

Additional Names

Long Common Name
Bruton tyrosine kinase [Interpretation] in B cells+monocytes by Flow cytometry (FC) Narrative
Short Name
Btk B cells+mono FC-Imp
Display Name
Bruton tyrosine kinase FC Nar (B cells+monocytes) [Interp]
Consumer Name Alpha Get Info
Interpretation of Bruton tyrosine kinase test result, B Cells+monocytes

Basic Attributes

Class
CELLMARK
Type
Laboratory
First Released
Version 2.50
Last Updated
Version 2.50 (MIN)
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Κινάση τυροσίνης Bruton:Imp:Pt:Β κύτταρα+μονοκύτταρα:Nar:Κυτταρομετρία ροής
Synonyms: Imp Κινάση τυροσίνης Bruton Τυροσίνη
es-ES Spanish (Spain) Tirosina quinasa de Bruton:Impresión/interpretación del estudio:Punto temporal:Células B + monocitos:Narrativo:Citometria de flujo (FC)
es-MX Spanish (Mexico) Tirosina quinasa de Bruton:Impresión / interpretación del estudio:Punto temporal:Células B + monocitos:Narrativo:Citometría de flujo (FC)
fr-FR French (France) BTK:Interprétation:Ponctuel:Lymphocytes B+monocytes:Résultat textuel:Cytométrie de flux
it-IT Italian (Italy) Tirosina chinasi di Bruton:Imp:Pt:Cellule B+monociti:Nar:Citometria a flusso
Synonyms: Citometria a flusso (FC) Impressione/interpretazione di studio Modelli di superficie cellulare Punto nel tempo (episodio)
nl-NL Dutch (Netherlands) brutontyrosinekinase:interpretatie:moment:B-cellen en monocyten:tekstueel:flowcytometrie
Synonyms: bruton tyrosine kinase
tr-TR Turkish (Turkey) Bruton irozin kinaz:İzlnm:Zmlı:B hücreleri+monositler:Öykü:Akış sitometri
Synonyms: Akış hücremetresi
zh-CN Chinese (China) 布鲁顿酪氨酸激酶:印象:时间点:B 细胞+单核细胞:叙述型:流式细胞测量术
Synonyms: 3-对羟苯基丙氨酸;Tyr B 细胞+单核 动态 印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释 叙述;叙述性文字;报告;报告型;文字叙述;文本叙述型;文本描述;文本描述型 布鲁顿氏酪氨酸激酶;BTK;布鲁顿氏酪胺酸激酶;Bruton 酪氨酸激酶 时刻;随机;随意;瞬间 流 流式细胞光度计;流式细胞测量术（Flow Cytometry，FC）;流式细胞计 细胞标志物

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=75708-8