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Term Description

Analysis of the Bruton tyrosine kinase (Btk) protein by flow cytometry is performed as a preliminary screen for X-linked agammaglobulinemia (XLA), primarily in male patients (<65 years of age) or female carriers (child-bearing age: <45 years). Since genotype-phenotype correlations are important, BTK gene sequencing LOINC 35295-5 is performed when the Btk protein is absent by flow cytometry to confirm the diagnosis of XLA.

Part Description

LP185945-5   Bruton tyrosine kinase
Bruton tyrosine kinase (Btk) is an intracellular protein that plays a crucial role in B-cell development. Mutations in the BTK gene are known to cause primary immunodeficiency disease X-linked agammaglobulinemia (XLA, Bruton's agammaglobulinemia). Approximately 20% to 30% of XLA patients may have intact or truncated Btk protein with abnormal function. Therefore, gene mutation analysis by sequencing or other methods is more definitive for diagnosing XLA. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Bruton tyrosine kinase:Imp:Pt:B cells+monocytes:Nar:Flow cytometry
Long Common Name
Bruton tyrosine kinase [Interpretation] in B cells+monocytes by Flow cytometry (FC) Narrative
Short Name
Btk B cells+mono FC-Imp
Display Name
Bruton tyrosine kinase FC Nar (B cells+monocytes) [Interp]
Consumer Name Alpha Get Info
Interpretation of Bruton tyrosine kinase test result, B Cells+monocytes

Part Model Get Info

  • Component
    Bruton tyrosine kinase
    LP185945-5
    • Analyte
      Bruton tyrosine kinase
      LP185945-5
      • Component Numerator
        Bruton tyrosine kinase
        LP185945-5
        • Component Numerator Core
          Bruton tyrosine kinase
          LP185945-5
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Imp
    LP6819-9
  • Time
    Pt
    LP6960-1
  • System
    B cells+monocytes
    LP186126-1
    • System Core
      B cells+monocytes
      LP186126-1
    • Super System
      NULL
       
  • Scale
    Nar
    LP7749-7
  • Method
    Flow cytometry
    LP6274-7

Basic Attributes

Class
CELLMARK
Type
Laboratory
First Released
Version 2.50
Last Updated
Version 2.50 (MIN)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Tyrosinkináza Brutonova:Interpretace:Časový bod:B buňky a monocyty:Narativní:Průtoková cytometrie
el-GRGreek (Greece)Κινάση τυροσίνης Bruton:Imp:Pt:Β κύτταρα+μονοκύτταρα:Nar:Κυτταρομετρία ροής
Synonyms: CELLMARK Imp Nar Pt Β κύτταρα+μονοκύτταρα Κινάση τυροσίνης Bruton Κυτταρομετρία ροής Τυροσίνη
es-ESSpanish (Spain)Tirosina quinasa de Bruton:Impresión/interpretación del estudio:Punto temporal:Células B + monocitos:Narrativo:Citometria de flujo (FC)
es-MXSpanish (Mexico)Tirosina quinasa de Bruton:Impresión / interpretación del estudio:Punto temporal:Células B + monocitos:Narrativo:Citometría de flujo (FC)
fr-FRFrench (France)BTK:Interprétation:Ponctuel:Lymphocytes B+monocytes:Résultat textuel:Cytométrie de flux
it-ITItalian (Italy)Tirosina chinasi di Bruton:Imp:Pt:Cellule B+monociti:Nar:Citometria a flusso
Synonyms: Citometria a flusso (FC) Impressione/interpretazione di studio Modelli di superficie cellulare Punto nel tempo (episodio)
nl-NLDutch (Netherlands)brutontyrosinekinase:interpretatie:moment:B-cellen en monocyten:tekstueel:flowcytometrie
Synonyms: bruton tyrosine kinase
tr-TRTurkish (Turkey)Bruton irozin kinaz:İzlnm:Zmlı:B hücreleri+monositler:Öykü:Akış sitometri
Synonyms: Akış hücremetresi
zh-CNChinese (China)布鲁顿酪氨酸激酶:印象:时间点:B 细胞+单核细胞:叙述型:流式细胞测量术
Synonyms: 3-对羟苯基丙氨酸;Tyr B 细胞+单核 动态 印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释 叙述;叙述性文字;报告;报告型;文字叙述;文本叙述型;文本描述;文本描述型 布鲁顿氏酪氨酸激酶;BTK;布鲁顿氏酪胺酸激酶;Bruton 酪氨酸激酶 时刻;随机;随意;瞬间 流 流式细胞光度计;流式细胞测量术（Flow Cytometry，FC）;流式细胞计 细胞标志物

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=75708-8