75726-0
HTR2A gene c.-1438G>A [Presence] in Blood or Tissue by Molecular genetics method
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Part Descriptions
LP185940-6 HTR2A gene.c.-1438G>A
Antidepressant and antipsychotic medication selection may be determined based on a patient's genotype for various polymorphisms within the HTR2A and HTR2C genes, which encode the serotonin (5-hydroxytryptamine) receptors HTR2A and HTR2C. PMID: 15121641 Variants in HTR2A, for example c.102T>C and c.-1438G>A, have been found to affect response to selective serotonin reuptake inhibitors (SSRI) and risk for adverse drug reactions as well as response to the antipsychotic drugs clozapine and aripiprazole. PMID: 14514498, PMID: 10821369 Patients treated with antipsychotics and having significant weight gain have been positively correlated with a polymorphism in the promoter region of HTR2C, c.759C>T, where those with the -759T variant allele showed significantly less weight gain than those without this allele. PMID: 12668355
Source: Regenstrief LOINC
LP40502-4 HTR2A gene
The HTR2A gene is located on chromosome 13 at position q14-q21 and encodes one of the receptors for serotonin, a neurotransmitter with many roles.[HGNC Gene ID:5293] Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] [NCBI Gene ID: 3356]
Source: National Center for Biotechnology Information (NCBI) Gene, HTR2A gene
Fully-Specified Name
- Component
- HTR2A gene.c.-1438G>A
- Property
- PrThr
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Ord
- Method
- Molgen
Additional Names
- Short Name
- HTR2A c.-1438G>A Bld/T Ql
- Display Name
- HTR2A gene c.-1438G>A Molgen Ql (Bld/Tiss)
- Consumer Name Alpha Get Info
- HTR2A gene c.-1438G>A, Blood or tissue specimen
Example Answer List: LL2478-7
Source: Regenstrief LOINC| Answer | Code | Score | Answer ID |
|---|---|---|---|
| G/G (wild type) | LA19932-5 | ||
| G/A (heterozygous) | LA19933-3 | ||
| A/A (homozygous) | LA19934-1 |
Basic Attributes
- Class
- MOLPATH.MUT
- Type
- Laboratory
- First Released
- Version 2.50
- Last Updated
- Version 2.56
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Gen HTR2A c.-1438G>A: |
| es-MX | Spanish (Mexico) | Gen HTR2A. C-1438G> A: |
| fr-FR | French (France) | HTR2A gène mutation c.-1438G>A: |
| it-IT | Italian (Italy) | HTR2A, gene.c.-1438G>A: Synonyms: Gene HTR2A c.-1438G> |
| nl-NL | Dutch (Netherlands) | HTR2A-gen.c.-1438G>A: Synonyms: HTR2A gen.c.-1438G> |
| tr-TR | Turkish (Turkey) | HTR2A geni.c.-1438G>A: Synonyms: Mevcut |
| zh-CN | Chinese (China) | HTR2A 基因.c.-1438G>A: Synonyms: 5-HT-2A 5-羟基色胺受体 2A 基因 5-羟色胺受体 2A 基因 5-羟色胺受体 2A 基因（5-hydroxytryptamine receptor 2A gene， |
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Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright