Version 2.80

Part Description

LP188434-7   Methotrexate polyglutamates
Methotrexate (MTX) is a drug that is used to treat certain types of cancer as well as auto-immune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus and psoriasis. After uptake of MTX into cells, MTX is activated by the addition of glutamate residues and forms methotrexate polyglutamates (MTX-PGs), which are named based on the number of added glutamate residues (e.g. methotrexate triglutamate, MTX-PG3). The half-life of MTX in plasma is only several hours where as MTX PGs can persist in cells for weeks or months. PMID: 15677700 While high-dose MTX in the treatment of malignancy is due to the direct effect on tetrahydrofolate reductase and DNA synthesis, the long-term immune modulation of low-dose MTX therapy appears to be related to multiple metabolic effects of the MTX PGs. PMID: 20665136 Red blood cell MTX PG levels may be a marker for therapeutic response in patients treated with low-dose MTX, and low red blood cell MTX PG has been associated with poor clinical status in patients with RA. PMID: 15677700 Source: Regenstrief LOINC , PMID: 15677700

Fully-Specified Name

Component
Methotrexate polyglutamates
Property
SCnc
Time
Pt
System
RBC
Scale
Qn
Method

Additional Names

Long Common Name
Methotrexate polyglutamates [Moles/volume] in Red Blood Cells
Short Name
MTX-PGs RBC-sCnc
Display Name
Methotrexate polyglutamates (RBC) [Moles/Vol]
Consumer Name Alpha Get Info
Methotrexate polyglutamates, Red blood cells

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.52
Last Updated
Version 2.73 (MIN)
Change Reason
Added 's' to "polyglutamate" since result is based on multiple PGs (e.g. triglutamate, tetraglutamate, etc.)
Order vs. Observation
Both
Common Test Rank Get Info
14042

Member of these Panels

LOINC Long Common Name
81630-6 Methotrexate polyglutamates 1-5 and total panel - Red Blood Cells

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Πολυγλουταμινική μεθοτρεξάτη:SCnc:Pt:Ερυθρά αιμοσφαίρια:Qn:
Synonyms: SCnc Μεθοτρεξάτη Πολυγλουταμινική μεθοτρεξάτη
es-MX Spanish (Mexico) Poliglutamatos de metotrexato:Concentración de sustancias:Punto temporal:Eritrocitos:Cuantitativo:
es-ES Spanish (Spain) Metotrexato poliglutamato:Concentración de sustancia:Punto temporal:Glóbulos rojos:Qn:
Synonyms: Cuantitativo
fr-FR French (France) Méthotrexate polyglutamates:Moles/Volume:Ponctuel:Érythrocytes:Numérique:
it-IT Italian (Italy) Metotrexato poliglutammati:SCnc:Pt:RBC:Qn:
Synonyms: Concentrazione di Sostanza Globuli rossi Livelli farmacologici e tossicologia Punto nel tempo (episodio)
nl-NL Dutch (Netherlands) methotrexaat-polyglutamaat:mol/volume:moment:erytrocyten:kwantitatief:
Synonyms: rode bloedcellen
tr-TR Turkish (Turkey) Metotreksat poliglutamat:SubKons:Zmlı:Eritrosit:Kant:
Synonyms: RBC
zh-CN Chinese (China) 氨甲蝶呤多聚谷氨酸:物质的量浓度:时间点:红细胞:定量型:
Synonyms: C20H22N8O5;甲氨喋呤;氨甲基叶酸;氨甲蝶呤;甲基蝶啶胺;甲基蝶啶胺(化学不孕剂) RBC;RBCS;红血球;红血细胞;赤血球 克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 氨甲蝶呤（甲氨喋呤、氨甲基叶酸、氨甲蝶呤、甲基蝶啶胺）多聚谷氨酸;聚谷氨酸化甲氨蝶呤;多聚谷氨酸化甲氨蝶呤;MTX-PG;MTXPG;MTX-PGs;MTXPGs 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类

Example Units

Unit Source
nmol/L{RBCs} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=76351-6