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Part Description

LP188418-0   Sheep prion protein codon 154
Scrapie is a fatal, degenerative disease affecting the central nervous system of sheep and goats. It is in the same class of diseases as BSE in cattle and Chronic Wasting Disease in elk and deer. Transmission of the classical scrapie agent is not completely understood but apparently healthy sheep infected with the agent can transmit disease. The infecting agent or prion is a mal-formed version (PrPsc ) of a normal protein (PrP) found in all animals. The malformation of the normal prion proteins occurs when they are exposed to the mal-formed version of the protein. The normal prion proteins may be more or less susceptible to malformation when they are exposed to the mal-formed protein based on their genetic makeup. Resistance or susceptibility has been linked to the presence of certain amino acids at various locations within the normal protein. Genotyping determines the amino acids present at specific locations or codons in the prion protein. These are reported as a pair of one character amino acid codes such as RR, RH, QQ, etc. This testing does not diagnosis Scrapie, but is an important tool for selecting genetically resistant animals for breeding and eradication. Codons associated with susceptibility/resistance to scrapie include codon 112, 136, 141, 154 and 171. Codon 154 codes for either arginine ® or histidine (H). The presence of H at codon 154 has been associated with increased resistance to scrapie. Source: American Association of Veterinary Laboratory Diagnosticians

LOINC Names Get Info

Fully-Specified Name
Sheep prion protein codon 154:Type:Pt:Bld:Nom:Genotyping
Long Common Name
Sheep prion protein codon 154 [Type] in Blood by Genotype method
Short Name
Sheep PrP codon 154 Bld Genotyp
Display Name
Sheep prion protein codon 154 Genotyping Nom (Bld)
Consumer Name Alpha Get Info
Sheep prion protein codon 154, Blood

Part Model Get Info

  • Component
    Sheep prion protein codon 154
    LP188418-0
    • Analyte
      Sheep prion protein codon 154
      LP188418-0
      • Component Numerator
        Sheep prion protein codon 154
        LP188418-0
        • Component Numerator Core
          Sheep prion protein codon 154
          LP188418-0
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Type
    LP6886-8
  • Time
    Pt
    LP6960-1
  • System
    Bld
    LP7057-5
    • System Core
      Bld
      LP7057-5
    • Super System
      NULL
       
  • Scale
    Nom
    LP7750-5
  • Method
    Genotyping
    LP28723-2

Example Answer List: LL3162-6

Source: American Association of Veterinary Laboratory Diagnosticians
AnswerCodeScoreAnswer ID
RRLA21971-9
RHLA21972-7
HHLA21447-0

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.52
Last Updated
Version 2.52 (MIN)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Ovčí prionový protein kodon 154:Typ:Časový bod:Krev:Nominální:Genotypizace
el-GRGreek (Greece)Κωδικόνιο πρωτεΐνης πριόν προβάτου 154:Type:Pt:Αίμα:Nom:Γονοτύπηση
Synonyms: MOLPATH Nom Pt Type Αίμα Γονοτύπηση Κωδικόνιο πρωτεΐνης πριόν προβάτου 154 Πρωτεΐνη
es-MXSpanish (Mexico)Codón 154 de proteína priónica de oveja:Tipo:Punto temporal:Sangre:Nominal:Susceptibilidad del genotipo viral
es-ESSpanish (Spain)proteína priónica en oveja, codon 154:Tipo:Punto temporal:Sangre:Nom:Susceptibilidad al genotipo viral
it-ITItalian (Italy)Pecora, proteina prionica codone 154:Tipo:Pt:Sangue:Nom:Genotipizzazione
Synonyms: Patologia molecolare Punto nel tempo (episodio) Sangue Suscettibilità al genotipo virale
nl-NLDutch (Netherlands)schapen prionproteïne codon 154:type:moment:bloed:nominaal:genotypering
pl-PLPolish (Poland)Białko prionowe owcy kodon 154:typ:punkt w czasie:krew:skala nominalna:genotypowanie
Synonyms: wynik kategorialny
tr-TRTurkish (Turkey)Koyun prion proteini kodon 154:Tip:Zmlı:Kan:Snf:Genotipleme
Synonyms: Tür
zh-CNChinese (China)绵羊朊蛋白密码子 154:类型:时间点:全血:名义型:基因分型
Synonyms: PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 亲染子蛋白 分子病理学;分子病理学试验 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 型 基因型分型;基因型分析;基因型定型;基因定型;病毒基因型敏感性试验 感染性蛋白质 时刻;随机;随意;瞬间 绵羊朊蛋白（朊病毒蛋白）密码子 154 绵羊科动物 蛋白感染素 血;血液

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=76415-9