77016-4

Fetal RhD antigen in Plasma cell-free DNA by MS.MALDI-TOF

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Term Description

This term was created for, but is not limited in use to, Sequenom Laboratories' SensiGene Fetal RhD genotyping test, which analyzes circulating cell-free DNA extracted from maternal plasma to determine the fetal RHD genotype using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry.

Part Description

LP186074-3 MS.MALDI-TOF
Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) is a type of mass spectrometry (MS). MALDI-TOF MS consists of three primary steps: 1) mixing the sample with an organic matrix, which provides a scaffolding and also protons for the ionization process; 2) applying a laser to the matrix, which absorbs energy from the laser and releases it into the sample, which causes the sample to desorb and form singly charged ions; and 3) using a flight tube to analyze the mass of the ions, ultimately resulting in a mass spectrum in which the mass-to-charge is plotted against signal intensity. MALDI-TOF is a soft ionization technique, meaning that molecules remain relatively intact during ionization. Because of this property, MALDI-TOF can be used for protein analysis; in contrast, older MS techniques cause extensive protein fragmentation and therefore cannot be used for this purpose. One application of MALDI-TOF is in clinical microbiology; compared to traditional methods, MALDI-TOF is faster and more accurate in identifying specific microorganisms. PMID: 23824373 Source: Regenstrief LOINC , PMID: 23824373

Fully-Specified Name

Component: Fetal RhD antigen
Property: Prid
Time: Pt
System: Plas.cfDNA
Scale: Nom
Method: MS.MALDI-TOF

Additional Names

Long Common Name: Fetal RhD antigen in Plasma cell-free DNA by MS.MALDI-TOF
Short Name: Fet RhD Ag Type Plas.cfDNA MS.MALDI-TOF
Display Name: RhD antigen MS.MALDI-TOF Nom (cfDNA)
Consumer Name Alpha Get Info: Fetal RhD antigen

Example Answer List: LL3288-9

Source: Sequenom, Inc.

Answer	Code	Score	Answer ID
RhD positive			LA22747-2
RhD negative			LA22748-0
Psi(+)/RhD variant			LA22749-8
InconclusiveCopyright http://snomed.info/sct ID:419984006 Inconclusive (qualifier value)			LA9663-1
Test not performedCopyright http://snomed.info/sct ID:262008008 Not performed (qualifier value)			LA13546-9

Basic Attributes

Class: MOLPATH
Type: Laboratory
First Released: Version 2.52
Last Updated: Version 2.68 (MIN)
Change Reason: Added "Fetal" to Component to clarify that the result is about the fetus.
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
el-GR	Greek (Greece)	Εμβρυικό αντιγόνο RhD:Prid:Pt:Πλάσμα.cfDNA:Nom:MS.MALDI-TOF Synonyms: Prid Εμβρυικό αντιγόνο RhD
es-ES	Spanish (Spain)	Antígeno RhD:Presencia o identidad:Punto temporal:ADN en plasma libre de células:Nom:MS.MALDI-TOF
es-MX	Spanish (Mexico)	Antígeno RhD fetal:Presencia o identidad:Punto temporal:ADN libre de células plasmáticas:Nominal:SRA. MALDI-TOF
fr-FR	French (France)	RhD antigène foetal:Identification:Ponctuel:Plasma avec ADN libre circulant:Résultat nominal:Spectrométrie MALDI-TOF
it-IT	Italian (Italy)	RhD, antigene:Prid:Pt:Plasma.DNA libero circolante:Nom:MS.MALDI-TOF Synonyms: Antigene RhD DNA libero circolante nel plasma Patologia molecolare Plasma Presenza o Identità Punto nel tempo (episodio)
nl-NL	Dutch (Netherlands)	foetaal RhD-antigeen:identificator:moment:plasma.celvrij DNA:nominaal:MALDI-TOF Synonyms: circulerend DNA massaspectometrie; Malditof RhD-antigeen bij foetus
zh-CN	Chinese (China)	胎儿 RhD 抗原:存在与否或特征标识:时间点:血浆.cfDNA:名义型:MS.MALDI-TOF Synonyms: Ag 分子病理学;分子病理学试验分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答基质辅助激光解吸/电离飞行时间质谱;基质辅助激光解吸电离飞行时间质谱;基质辅助激光解吸飞行时间质谱;基质辅助激光解析电离飞行时间质谱;Matrix-Assisted Laser Desorption/ Ionization Time of Flight Mass Spectrometry;MALDI-TOF-MS;Matrix-assisted laser desorption ionization-time of flight 存在;存在与否;特征标识;身份;身份标识抗体原时刻;随机;随意;瞬间胎儿 RhD Ag 血浆循环 cfDNA;血浆循环 DNA;循环游离核酸;血浆游离 DNA;血浆无细胞 DNA;Free circulating/Cell-free DNA;Free circulating DNA

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