LOINC
Version 2.67

77173-3Hepatocyte growth factor receptor Ag [Presence] in Tissue by Immune stainActive

Term Description

The stain is interpreted as positive if 50% or more of the tumor cells show moderate to strong (2+, 3+) membranous staining, indicating MET amplification. MET amplification (positive) has been seen in approximately 22% of non-small-cell lung cases with acquired resistance to anti-EGFR inhibitors. Recent Phase II clinical trails (OAM4558g) results were released at ASCO in 2011 showed that patients who were c-MET positive (2+ or 3+) lived twice as long without disease progression (PFS) when they received MetMAb therapy in combination with erlotinib versus receiving erlotinib alone.
Source: Regenstrief LOINC

Part Description

LP189738-0   Hepatocyte growth factor receptor
Hepatocyte growth factor receptor (HGFR, also known as mesenchymal-epithelial transition (MET or c-MET]) is a transmembrane tyrosine kinase receptor that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. [UniProt: P08581] The HGFR is a product of the MET gene and is important to oncogenesis and normal cellular function. It regulates many physiological processes including proliferation, scattering, morphogenesis and survival. The HGFR can be overexpressed in epithelial cancers, such as lung cancer. The overexpression of c-MET is thought to allow for cell migration and invasion leading to metastasis as well as growth advantage. [PMID: 24005867] Source: Regenstrief LOINC

Fully-Specified Name

Component
Hepatocyte growth factor receptor Ag
Property
PrThr
Time
Pt
System
Tiss
Scale
Ord
Method
Immune stain

Additional Names

Short Name
HGFR Ag Tiss Ql ImStn
Display Name
Hepatocyte growth factor receptor Ag Immune stain Ql (Tiss)

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.52
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
肝细胞生长因子受体 抗原:存在情况或阈值:时间点:组织与涂片:序数型:免疫染色法
nl-NLDutch (NETHERLANDS)
hepatocyt groeifactorreceptor Ag:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:immunokleuring
fr-FRFrench (FRANCE)
Facteur de croissance hépatocytaire récepteur antigène:Présence/Seuil:Ponctuel:Tissu:Qualitatif:Coloration immune
it-ITItalian (ITALY)
Recettore fattore di crescita degli epatociti , Ag:PrThr:Pt:Tessuto:Ord:Colorazione immunologica
es-ESSpanish (SPAIN)
Receptor del factor de crecimiento de hepatocitos Antígeno:PrThr:Punto temporal:Tejido:Ord:Tinción de inmunohistoquímica
tr-TRTurkish (TURKEY)
Hepatosit büyüme faktörü reseptörü Ag:MevcEşik:Zmlı:Doku:Srl:İmmün boyama

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=77173-3