LOINC
Version 2.67

77206-1Norbuprenorphine [Presence] in Saliva (oral fluid) by Confirmatory methodActive

Term Description

This is a confirmatory test for the presence of norbuprenorphine, a metabolite of buprenorphine, in saliva. The result is reported as positive or negative based on the quantitative result.
Source: Regenstrief LOINC

Part Descriptions

LP34568-3   Norbuprenorphine
Buprenorphine (tradename Buprenex), is a long-lasting, high affinity opioid that acts on the same receptors as heroin and morphine but does not produce the same intense high or dangerous side effects. It is used for the treatment of pain and opioid dependence. The major buprenorphine metabolites are norbuprenorphine, buprenorphine-3-glucuronide (B3G), and norbuprenorphine-3-glucuronide (N3G). The analysis of buprenorphine and metabolites is performed to monitor compliance to drug therapy. Source: Regenstrief LOINC

LP34568-3   Norbuprenorphine
Norbuprenorphine is the primary active metabolite of buprenorphine, and its mean steady-state plasma concentration is comparable to or even exceeds that of buprenorphine following sublingual buprenorphine absorption (Kuhlman et al., 1998). It is likely to contribute to the overall pharmacological effects of buprenorphine. Buprenorphine and norbuprenorphine displayed distinct pharmacological properties at mu-opioid, delta-opioid, and kappa-opioid receptors and the ORL1 receptor. [PMID: 11303059] Source: Regenstrief LOINC

LP7565-7   Saliva
Saliva is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. [PMID: 17268583] Source: Regenstrief LOINC

LP262420-5   Saliva DRUG/TOX
Oral fluid (or saliva) is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. The test procedures that use oral fluid for drug screening are usually similar to those for other specimens but adapted for oral fluid. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Drugs present in oral fluid are often the parent drug rather than a metabolite and tests kits reflect those differences. Concentrations of cocaine, amphetamines and some opioids in oral fluid are either similar or higher than concentrations in plasma. The concentration of tetrahydrocannabinol (THC) in oral fluid is similar to that of plasma, though in cases where recent ingestion has occurred, levels may be higher due to the significant local absorption in the oral cavity. Confirmatory testing on oral fluid using liquid chromatography-mass spectrometry (LC-MS) is highly sensitive and specific even on relatively small sample sizes. An increased understanding of pharmacokinetics in oral fluid has flourished inover the last ten years has allowed the correlation of . As a result, the concentrations of various drugs in oral fluid have been correlated to blood concentrations and the effects they have on the individual. [PMID: 17268583] Source: Regenstrief LOINC

Fully-Specified Name

Component
Norbuprenorphine
Property
PrThr
Time
Pt
System
Saliva
Scale
Ord
Method
Confirm

Additional Names

Short Name
Norbuprenorphine Sal Ql Cfm
Display Name
Norbuprenorphine Confirm Ql (Sal)

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.52
Last Updated
Version 2.63
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; Because it is too difficult to maintain and because the distinction between documents and sections is not clear-cut nor necessary in most cases, the DOCUMENT_SECTION field has been deemed to have little value. The field has been set to null in the December 2017 release in preparation for removal in the December 2018 release. These changes were approved by the Clinical LOINC Committee.
Order vs. Observation
Observation

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Member of these Groups

LG50147-4 Norbuprenorphine|ANYProp|ANYTm|ANYSys|ANYMeth

Language Variants Get Info

zh-CNChinese (CHINA)
去甲基丁丙诺啡:存在情况或阈值:时间点:唾液:序数型:毒理学确认试验
nl-NLDutch (NETHERLANDS)
norbuprenorfine:aanwezigheid:moment:speeksel:ordinaal:bevestiging
et-EEEstonian (ESTONIA)
Norbuprenorfiin:PrThr:Pt:Sal:Ord:Kinnitav
fr-BEFrench (BELGIUM)
Norbuprenorphine:PrThr:Temps ponctuel:Salivaire:Ordinal:Confirmé
fr-CAFrench (CANADA)
Norbuprénorphine:Présence-Seuil:Temps ponctuel:Salivaire:Ordinal:Confirmé
fr-FRFrench (FRANCE)
Norbuprénorphine:Présence/Seuil:Ponctuel:Salive:Qualitatif:Confirmation
it-ITItalian (ITALY)
Norbuprenorfina:PrThr:Pt:Saliva:Ord:Conferma
ru-RURussian (RUSSIAN FEDERATION)
Норбупренорфин:PrThr:ТчкВрм:Слюна:Пор:Подтверждать
es-ESSpanish (SPAIN)
Norbuprenorfina:PrThr:Punto temporal:Saliva:Ord:Confirmatorio
tr-TRTurkish (TURKEY)
Norbuprenorfin:MevcEşik:Zmlı:Tükürük:Srl:Onay

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=77206-1