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Term Description

This term was created for, but is not limited in use to, Exact Sciences' Cologuard DNA screening test for colorectal cancer. The Cologuard algorithm includes two laboratory procedures performed on a single stool specimen: 1) detection and quantification of fecal occult blood using ELISA; and 2) detection of multiple genetic biomarkers (NDRG4 and BMP3 methylation targets, seven KRAS point mutations, and beta actin as a proxy for the total amount of human DNA in each sample) using magnetic bead based oligonucleotide hybrid capture to isolate the biomarkers followed by quantitative real-time target and signal amplification. The occult blood and genetic biomarker results are subsequently entered into a logistic regression model, and the results from this model are used to calculate a composite score from which the final binary result (positive, negative) is determined. PMID: 24645800

LOINC Names Get Info

Fully-Specified Name
Noninvasive colorectal cancer DNA+occult blood screening:Imp:Pt:Stool:Nar:
Long Common Name
Noninvasive colorectal cancer DNA and occult blood screening [Interpretation] in Stool Narrative
Short Name
Noninv colon ca DNA+occ bld scrn Stl-Imp
Display Name
Noninvasive colorectal cancer DNA and occult blood screening Nar (Stl) [Interp]
Consumer Name Alpha Get Info
Interpretation of Noninvasive Colorectal Cancer DNA and Occult Blood Screening test result, Stool

Part Model Get Info

  • Component
    Noninvasive colorectal cancer DNA+occult blood screening
    LP189760-4
    • Analyte
      Noninvasive colorectal cancer DNA+occult blood screening
      LP189760-4
      • Component Numerator
        Noninvasive colorectal cancer DNA+occult blood screening
        LP189760-4
        • Component Numerator Core
          Noninvasive colorectal cancer DNA+occult blood screening
          LP189760-4
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Imp
    LP6819-9
  • Time
    Pt
    LP6960-1
  • System
    Stool
    LP7604-4
    • System Core
      Stool
      LP7604-4
    • Super System
      NULL
       
  • Scale
    Nar
    LP7749-7
  • Method
    NULL
     

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.52
Last Updated
Version 2.73 (MIN)
Order vs. Observation
Observation
Common Test Rank Get Info
4228

Member of these Panels

LOINCLong Common Name
82955-6HEDIS 2017 Value Sets
87625-0HEDIS 2018 Value Sets
90766-7HEDIS 2019 Value Sets
94137-7HEDIS 2020 Value Sets
96068-2HEDIS MY 2020 Value Sets

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Kolorektální karcinom neinvazivní screeningový test DNA a okultního krvácení:Interpretace:Časový bod:Stolice:Narativní:
el-GRGreek (Greece)Μη επεμβατικός έλεγχος DNA+εξέταση κρυφού αίματος για καρκίνο του παχέος εντέρου:Imp:Pt:Κόπρανα:Nar:
Synonyms: DNA Imp MOLPATH Nar Pt Αίμα Καρκίνος Κόπρανα Μη επεμβατικός έλεγχος DNA+εξέταση κρυφού αίματος για καρκίνο του παχέος εντέρου
es-ESSpanish (Spain)Screening no invasivo de cancer colorectal ADN+sangre oculta:Impresión/interpretación del estudio:Punto temporal:Heces:Narrativo:
es-MXSpanish (Mexico)Análisis de ADN + sangre oculta de cáncer colorrectal no invasivo:Impresión / interpretación del estudio:Punto temporal:Heces:Narrativo:
fr-FRFrench (France)Cancer colorectal non invasif ADN+sang occulte dépistage:Interprétation:Ponctuel:Selle:Résultat textuel:
it-ITItalian (Italy)Screening non invasivo DNA+sangue occulto tumore colorettale:Imp:Pt:Feci:Nar:
Synonyms: Impressione/interpretazione di studio Patologia molecolare Punto nel tempo (episodio) Screening non invasivo DNA e sangue occulto per di
pl-PLPolish (Poland)Nieinwazyjne badanie przesiewowe DNA raka jelita grubego+krew utajona:ocena:punkt w czasie:kał:opisowy:
Synonyms: Kwas deoksyrybonukleinowy Nieinwazyjne badanie przesiewowe DNA i krwi utajonej w kale w kierunku raka jelita grubego
tr-TRTurkish (Turkey)Noninvaziv kolorektal kanser DNA+gaitada gizli kan tarama:İzlnm:Zmlı:Dışkı:Öykü:
Synonyms: Gaita; feçes
zh-CNChinese (China)无创性结直肠癌 DNA+潜血筛查:印象:时间点:大便:叙述型:
Synonyms: Asympt SCN 便;大肠运动;排便;粪便;肠运动 分子病理学;分子病理学试验 印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释 去氧核糖核酸;脱氧核糖核酸;脱氧核糖核酸（Deoxyribonucleic acid，DNA） 叙述;叙述性文字;报告;报告型;文字叙述;文本叙述型;文本描述;文本描述型 无创性（非侵入性、无创）结直肠癌（结肠癌、直肠癌） DNA+潜血（隐血、OB）筛查（筛选、普查） 无症状 无症状（Asymptomatic，Asympt） 无症状的 无症状筛查 时刻;随机;随意;瞬间 普查 普查试验 癌 筛分 筛分试验 筛查（Screening，SCN） 筛查试验 筛选 筛选试验 血;全血

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