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Term Description

This term was created for, but is not limited in use to, Exact Sciences' Cologuard DNA screening test for colorectal cancer. The Cologuard algorithm includes two laboratory procedures performed on a single stool specimen: 1) detection and quantification of fecal occult blood using ELISA; and 2) detection of multiple genetic biomarkers (NDRG4 and BMP3 methylation targets, seven KRAS point mutations, and beta actin as a proxy for the total amount of human DNA in each sample) using magnetic bead based oligonucleotide hybrid capture to isolate the biomarkers followed by quantitative real-time target and signal amplification. The occult blood and genetic biomarker results are subsequently entered into a logistic regression model, and the results from this model are used to calculate a composite score from which the final binary result (positive, negative) is determined. PMID: 24645800

LOINC Names Get Info

Fully-Specified Name
Noninvasive colorectal cancer DNA+occult blood screening:PrThr:Pt:Stool:Ord:
Long Common Name
Noninvasive colorectal cancer DNA and occult blood screening [Presence] in Stool
Short Name
Noninv colon ca DNA+occ bld scrn Stl Ql
Display Name
Noninvasive colorectal cancer DNA and occult blood screening Ql (Stl)
Consumer Name Alpha Get Info
Noninvasive Colorectal Cancer DNA and Occult Blood Screening, Stool

Part Model Get Info

  • Component
    Noninvasive colorectal cancer DNA+occult blood screening
    LP189760-4
    • Analyte
      Noninvasive colorectal cancer DNA+occult blood screening
      LP189760-4
      • Component Numerator
        Noninvasive colorectal cancer DNA+occult blood screening
        LP189760-4
        • Component Numerator Core
          Noninvasive colorectal cancer DNA+occult blood screening
          LP189760-4
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Stool
    LP7604-4
    • System Core
      Stool
      LP7604-4
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    NULL
     

Example Answer List: LL3293-9

Source: Exact Sciences Laboratories
AnswerCodeScoreAnswer ID
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)LA6577-6
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)LA6576-8
Sample could not be processedLA22772-0
No result obtainedLA22773-8

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.52
Last Updated
Version 2.73 (MIN)
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common Test Rank Get Info
2032

Member of these Panels

LOINCLong Common Name
82955-6HEDIS 2017 Value Sets
87625-0HEDIS 2018 Value Sets
90766-7HEDIS 2019 Value Sets
94137-7HEDIS 2020 Value Sets
96068-2HEDIS MY 2020 Value Sets

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Kolorektální karcinom neinvazivní screeningový test DNA a okultního krvácení:Přítomnost nebo práh:Časový bod:Stolice:Ordinální:
el-GRGreek (Greece)Μη επεμβατικός έλεγχος DNA+εξέταση κρυφού αίματος για καρκίνο του παχέος εντέρου:PrThr:Pt:Κόπρανα:Ord:
Synonyms: DNA MOLPATH Ord PrThr Pt Αίμα Καρκίνος Κόπρανα Μη επεμβατικός έλεγχος DNA+εξέταση κρυφού αίματος για καρκίνο του παχέος εντέρου
es-ESSpanish (Spain)Screening no invasivo de cancer colorectal ADN+sangre oculta:PrThr:Punto temporal:Heces:Ord:
es-MXSpanish (Mexico)Análisis de ADN + sangre oculta de cáncer colorrectal no invasivo:Presencia o umbral:Punto temporal:Heces:Ordinal:
fr-FRFrench (France)Cancer colorectal non invasif ADN+sang occulte dépistage:Présence/Seuil:Ponctuel:Selle:Qualitatif:
it-ITItalian (Italy)Screening non invasivo DNA+sangue occulto tumore colorettale:PrThr:Pt:Feci:Ord:
Synonyms: Patologia molecolare Presenza o Soglia Punto nel tempo (episodio) Screening non invasivo DNA e sangue occulto per di
pl-PLPolish (Poland)Nieinwazyjne badanie przesiewowe DNA raka jelita grubego+krew utajona:granica wykrywalności:punkt w czasie:kał:uporządkowany:
Synonyms: Kwas deoksyrybonukleinowy Nieinwazyjne badanie przesiewowe DNA i krwi utajonej w kale w kierunku raka jelita grubego
tr-TRTurkish (Turkey)Noninvaziv kolorektal kanser DNA+gaitada gizli kan tarama:MevcEşik:Zmlı:Dışkı:Srl:
Synonyms: Gaita; feçes Mevcut
zh-CNChinese (China)无创性结直肠癌 DNA+潜血筛查:存在情况或阈值:时间点:大便:序数型:
Synonyms: Asympt SCN 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 便;大肠运动;排便;粪便;肠运动 分子病理学;分子病理学试验 去氧核糖核酸;脱氧核糖核酸;脱氧核糖核酸（Deoxyribonucleic acid，DNA） 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 无创性（非侵入性、无创）结直肠癌（结肠癌、直肠癌） DNA+潜血（隐血、OB）筛查（筛选、普查） 无症状 无症状（Asymptomatic，Asympt） 无症状的 无症状筛查 时刻;随机;随意;瞬间 普查 普查试验 癌 筛分 筛分试验 筛查（Screening，SCN） 筛查试验 筛选 筛选试验 血;全血

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=77354-9