Version 2.78

Term Description

Detection of truncated gene variants of the erm(41) gene unique to Mycobacterium abscessus complex, particularly M. abscessus subsp. massiliense, from clinical isolates by real-time PCR.
Source: Regenstrief LOINC

Part Description

LP190748-6   Mycobacterium abscessus complex clarithromycin resistance erm(41) truncated gene
The M. abscessus complex consists of three subspecies (M. abscessus subsp. Abscessus, M. abscessus subsp. Massiliense, M. abscessus subsp. Bolletii). PMID: 22403419 They are known to cause respiratory disease in cystic fibrosis and elderly patients as well as skin and soft tissue infections. PMID: 25106861 M. abscessus infections are often difficult to treat as many strains are resistant to most of the common antibiotics. Their resistance to clarithromycin can be determined based on expression of the inducible ribomethylase gene, erm(41). The presence of a full length functional erm(41)gene, which is specific for M. abscessus, confers inducible resistance to clarithromycin while the non-functional truncated erm(41) gene exhibits higher drug susceptibility. PMID: 22290346 Real-time PCR methods are performed to detect the presence of the full or truncated erm(41) gene and determine proper treatment for patients. Source: Regenstrief LOINC

Fully-Specified Name

Component
Mycobacterium abscessus complex clarithromycin resistance erm(41) truncated gene
Property
PrThr
Time
Pt
System
Isolate/Specimen
Scale
Ord
Method
Molgen

Additional Names

Short Name
M absces erm(41) trunc Islt/Spm Ql
Display Name
M. abscessus complex clarithromycin resistance erm(41) truncated gene Molgen Ql (Islt/Spec)
Consumer Name Alpha Get Info
Mycobacterium abscessus complex clarithromycin resistance erm(41) truncated gene

Example Answer List: LL3596-5

Source: New York State Health (Wadsworth Center)
Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8
InconclusiveCopyright http://snomed.info/sct ID:419984006 Inconclusive (qualifier value) LA9663-1

Basic Attributes

Class
ABXBACT
Type
Laboratory
First Released
Version 2.52
Last Updated
Version 2.65
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; Removed parentheses from Component because the contents represent a gene name, not an acronym; Updated System from "Isolate" and Method from "Probe.amp.tar" according to the new, more sustainable model for LOINC molecular resistance terms [Approved by LOINC Laboratory Committee in June 2018].
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
77737-5 Mycobacterium abscessus complex clarithromycin resistance erm(41) gene panel by Molecular genetics method

Language Variants Get Info

Tag Language Translation
de-DE German (Germany) Mycobacterium-abscessus-Komplex Clarithromycin-Resistenz verkürztes erm(41)-Gen:Nachweis oder Schwellenwert:Zeitpunkt:Isolat oder Probenmaterial:Ordinal:Molekulargenetisch
es-ES Spanish (Spain) Mycobacterium abscessus complex resistente a claritromicina (erm(41)) gen truncado:PrThr:Punto temporal:Muestra aislada:Ord:Genética molecular
es-MX Spanish (Mexico) Mycobacterium abscessus complex resistencia a claritromicina erm (41) gen truncado:Presencia o umbral:Punto temporal:Aislado o espécimen:Ordinal:Genética molecular
fr-FR French (France) Mycobacterium complexe abscessus résistance à la clarithromycine erm(41) gène tronqué:Présence/Seuil:Ponctuel:Isolat/échantillon:Qualitatif:Biologie moléculaire
it-IT Italian (Italy) Complesso Mycobacterium abscessus claritromicina resistente, gene troncato (erm(41)):PrThr:Pt:Isolato/Campione:Ord:Molgen
Synonyms: Genetica molecolare Isolato o Campione Presenza o Soglia Punto nel tempo (episodio) Suscettibilità agli antibiotici
nl-NL Dutch (Netherlands) Mycobacterium abscessus complex clarithromycine-resistent (erm(41)) afgekapt gen:aanwezigheid:moment:isolaat of monster:ordinaal:moleculair genetisch onderzoek
Synonyms: isolaat/specimen molgen
zh-CN Chinese (China) 脓肿分枝杆菌复合体克拉霉素耐药 erm(41) 截短基因:存在情况或阈值:时间点:分离株/标本:序数型:分子遗传学类实验室方法
Synonyms: AFB 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分支杆菌 分支杆菌属 分枝杆菌属 分离株/标本（样本、样品、试样） 分离物;分离菌;分离菌株;隔离种群 劳瘵 受检物 复合体 大环内酯类抗生素;第二代红霉素 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 抗力 抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类 抗耐性 抗酸 抗酸杆菌 抗酸杆菌（Acid fast bacillus，AFB） 抗酸菌 抵抗力 抵抗性 时刻;随机;随意;瞬间 样品 样本 电阻 痨 痨病 结核 结核病 耐性 肺结核 脓肿分枝杆菌（脓肿分支杆菌、化脓性分枝杆菌、化脓性分支杆菌）复合体（复合物）克拉霉素耐药（抗性、耐性、耐药性、抗药、抗药性、耐受、耐药型）erm(41) 截短（截断）基因 试样 遗传基因;遗传因子;吉恩;生物基因 阻力

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=77735-9