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Term Description

This term was created for, but is not limited in use to, the Vysis 4q12 Tri-Color Rearrangement FISH Probe Kit, which is intended to detect rearrangements in chromosome 4q12 involving the FIP1L1-PDGFRA region.

Part Descriptions

LP189752-1   4q12 chromosome region rearrangements
Chromosome region 4q12 rearrangements are associated with myeloid and lymphoid neoplasms due to disruption of the PDGFRA and/or FGFR1 genes. Patients with rearrangement(s) involving PDGFRA most commonly present with chronic eosinophilic leukemia but also can present as acute myeloid leukemia (AML) and/or T-lymphoblastic leukemia/lymphoma (T-ALL). Patients with FGFR1 involvement have various presentations including AML, T- or B-lymphoblastic leukemia/lymphoma (B-ALL), or a mixed phenotype acute leukemia. Imatinib mesylate (imatinib) is the first-line therapy for patients with abnormalities of PDGFRA, whereas patients with FGFR1 fusions are resistant to this therapy and carry a poor prognosis. PMID: 23489324 Source: Regenstrief LOINC

LP62864-1   FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, FISH

LOINC Names Get Info

Fully-Specified Name
4q12 chromosome region rearrangements:Prid:Pt:Bld/Tiss:Nom:FISH
Long Common Name
4q12 chromosome region rearrangements [Identifier] in Blood or Tissue by FISH Nominal
Short Name
4q12 rearrange Bld/T FISH
Display Name
4q12 chromosome region rearrangements FISH Nom (Bld/Tiss)
Consumer Name Alpha Get Info
4q12 chromosome region rearrangements, Blood or tissue specimen

Part Model Get Info

  • Component
    4q12 chromosome region rearrangements
    LP189752-1
    • Analyte
      4q12 chromosome region rearrangements
      LP189752-1
      • Component Numerator
        4q12 chromosome region rearrangements
        LP189752-1
        • Component Numerator Core
          4q12 chromosome region rearrangements
          LP189752-1
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Prid
    LP6850-4
  • Time
    Pt
    LP6960-1
  • System
    Bld/Tiss
    LP7061-7
    • System Core
      Bld/Tiss
      LP7061-7
    • Super System
      NULL
       
  • Scale
    Nom
    LP7750-5
  • Method
    FISH
    LP62864-1

Basic Attributes

Class
MOLPATH.REARRANGE
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.61 (MIN)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Chromozom oblast 4q12 přestavba:Přítomnost nebo identita:Časový bod:Krev/tkáň:Nominální:Fluorescenční in situ hybridizace (FISH)
el-GRGreek (Greece)Αναδιατάξεις χρωμοσωμικής περιοχής 4q12:Prid:Pt:Αίμα/Ιστός:Nom:Φθορίζουσα υβριδοποίηση in situ
Synonyms: MOLPATH MOLPATH.REARRANGE Nom Prid Pt Αίμα Αίμα/Ιστός Αναδιατάξεις χρωμοσωμικής περιοχής 4q12 Ιστός Περιοχή Φθορίζουσα υβριδοποίηση in situ Χρωμόσωμα Χρωμοσωμική περιοχή
es-ESSpanish (Spain)reordenamientos cromosoma 4q12:Presencia o identidad:Punto temporal:Sangre o tejido:Nom:Hibridación in situ fluoresente (FISH)
es-MXSpanish (Mexico)Reordenamientos de la región del cromosoma 4q12:Presencia o identidad:Punto temporal:Sangre o tejido:Nominal:Hibridación fluorescente in situ (FISH)
fr-FRFrench (France)Chromosome région 4q12 réarrangements:Identification:Ponctuel:Sang/Tissu:Résultat nominal:FISH
it-ITItalian (Italy)Riorganizzazioni della regione cromosomica 4q12:Prid:Pt:Sangue/Tess:Nom:FISH
Synonyms: Ibridazione in situ fluorescente (FISH) Patologia molecolare Presenza o Identità Punto nel tempo (episodio) Riarrangiamento genico Sangue Sangue o Tessuto Tessuto & Strisci
nl-NLDutch (Netherlands)4q12-chromosoomgebied translocaties:identificator:moment:bloed of weefsel:nominaal:FISH
Synonyms: 4q12-chromosoom gebied translocaties
pl-PLPolish (Poland)Rearanżacja regionu chromosomu 4q12:obecność lub identyfikacja:punkt w czasie:krew lub tkanka:skala nominalna:FISH
Synonyms: fluorescencyjna hybrydyzacja in situ wynik kategorialny
tr-TRTurkish (Turkey)4q12 Kromozom bölgesi yeniden düzenleme:MevcKimlik:Zmlı:Kan/Dk:Snf:FISH
zh-CNChinese (China)4q12 染色体区域重排:存在与否或特征标识:时间点:全血/组织:名义型:FISH
Synonyms: 4q12 染色体区域（染色体部位、染色体区、染色体区带、染色体部）重排 Fluorescent in situ hybridization;荧光原位杂交 全血或组织;血液/组织;血液或组织 分子病理学.基因重排;分子病理学.重排;分子病理学试验.基因重排;分子病理学试验.重排;分子病理学试验类.重排;基因重排;重排 分子病理学;分子病理学试验 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 区;地区;局部 存在;存在与否;特征标识;身份;身份标识 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 染色体二体型+染色体三体型 染色体部位;染色体区;染色体区带;染色体部;染色体区域（染色体部位、染色体区、染色体区带、染色体部） 血;血液

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=78201-1