78203-7
BCL6 gene rearrangements [Presence] in Blood or Tissue by FISH
Active
Term Description
This term was created for, but is not limited in use to, the LSI BCL6 (ABR) Dual Color, Break Apart Rearrangement Probe, which is intended to detect rearrangements in the BCL6 gene in the 3q27 chromosome region.
Source: Regenstrief LOINC
Part Descriptions
LP19776-1 BCL6 gene rearrangements
The protein encoded by the BCL6 gene arrangements is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
Source: National Center for Biotechnology Information (NCBI) Gene, BCL6 gene rearrangements
LP19776-1 BCL6 gene rearrangements
The BCL6 gene (B-cell CLL/lymphoma 6) [HGNC Gene ID:1001] is located on chromosome 3q27. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008] [NCBI Gene ID:604]
Source: National Center for Biotechnology Information (NCBI) Gene
LP62864-1 FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues.
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Source: Wikipedia, FISH
Fully-Specified Name
- Component
- BCL6 gene rearrangements
- Property
- PrThr
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Ord
- Method
- FISH
Additional Names
- Short Name
- BCL6 gene Rear Bld/T Ql FISH
- Display Name
- BCL6 rearrangements FISH Ql (Bld/Tiss)
- Consumer Name Alpha Get Info
- BCL6 rearrangements, Blood or tissue specimen
Example Answer List: LL744-4
Source: Regenstrief Institute| Answer | Code | Score | Answer ID |
|---|---|---|---|
| Detected | LA11882-0 | ||
| Not detected | LA11883-8 |
Basic Attributes
- Class
- MOLPATH.REARRANGE
- Type
- Laboratory
- First Released
- Version 2.54
- Last Updated
- Version 2.73
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 6718
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Reordenamientos del gen BCL6: |
| es-MX | Spanish (Mexico) | Reordenamientos del gen BCL6: |
| et-EE | Estonian (Estonia) | BCL6 geeni muudatused: Synonyms: Järgarvuline Juhuslik Kude Veri Veri või koematerjal |
| fr-FR | French (France) | BCL6 gène réarrangements: |
| it-IT | Italian (Italy) | BCL6, riarrangiamenti gene: Synonyms: Ibridazione in situ fluorescente (FISH) Patologia molecolare Presenza o Soglia Punto nel tempo (episodio) Riarrangiamenti gene BCL6 Riarrangiamento genico Sangue Sangue o Tessuto Tessuto & |
| nl-NL | Dutch (Netherlands) | BCL6-genherschikking: Synonyms: BCL6 gen translocaties |
| tr-TR | Turkish (Turkey) | BCL6 geni yeniden düzenlenmeler: Synonyms: Mevcut |
| zh-CN | Chinese (China) | BCL6 基因重排: Synonyms: BCL6 基因重排（重组）; |
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LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright