Version 2.77

Part Descriptions

LP19776-1   BCL6 gene rearrangements
The protein encoded by the BCL6 gene arrangements is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. Source: National Center for Biotechnology Information (NCBI) Gene, BCL6 gene rearrangements

LP19776-1   BCL6 gene rearrangements
The BCL6 gene (B-cell CLL/lymphoma 6) [HGNC Gene ID:1001] is located on chromosome 3q27. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008] [NCBI Gene ID:604] Source: National Center for Biotechnology Information (NCBI) Gene

LP62864-1   FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, FISH

Fully-Specified Name

Component
BCL6 gene rearrangements
Property
Imp
Time
Pt
System
Bld/Tiss
Scale
Nar
Method
FISH

Additional Names

Short Name
BCL6 gene Rear Bld/T FISH-Imp
Display Name
BCL6 rearrangements FISH Nar (Bld/Tiss) [Interp]
Consumer Name Alpha Get Info
Interpretation of BCL6 rearrangements test result, Blood or tissue specimen

Basic Attributes

Class
MOLPATH.REARRANGE
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.61
Order vs. Observation
Observation

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Reordenamientos del gen BCL6:Impresión/interpretación del estudio:Punto temporal:Sangre o tejido:Narrativo:Hibridación in situ fluoresente (FISH)
es-MX Spanish (Mexico) Reordenamientos del gen BCL6:Impresión / interpretación del estudio:Punto temporal:Sangre o tejido:Narrativo:Hibridación fluorescente in situ (FISH)
fr-FR French (France) BCL6 gène réarrangements:Interprétation:Ponctuel:Sang/Tissu:Résultat textuel:FISH
it-IT Italian (Italy) BCL6, riarrangiamenti gene:Imp:Pt:Sangue/Tess:Nar:FISH
Synonyms: Ibridazione in situ fluorescente (FISH) Impressione/interpretazione di studio Patologia molecolare Punto nel tempo (episodio) Riarrangiamenti gene BCL6 Riarrangiamento genico Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL Dutch (Netherlands) BCL6-genherschikking:interpretatie:moment:bloed of weefsel:tekstueel:FISH
Synonyms: BCL6 gen translocaties
tr-TR Turkish (Turkey) BCL6 geni yeniden düzenlenmeler:İzlnm:Zmlı:Kan/Dk:Öykü:FISH
zh-CN Chinese (China) BCL6 基因重排:印象:时间点:全血/组织:叙述型:FISH
Synonyms: BCL6 基因重排（重组）;B 细胞 CLL;B 细胞慢性淋巴细胞白血病;BCL5;LAZ3;ZNF51;慢性 B 淋巴细胞白血病;淋巴瘤 6;锌指蛋白 51;非 Hodgkin 氏淋巴瘤;非何杰金氏淋巴瘤;BCL-6 基因重排 BCL-6;B-细胞白血病/淋巴瘤 6;B细胞白血病/淋巴瘤6 Fluorescent in situ hybridization;荧光原位杂交 全血或组织;血液/组织;血液或组织 分子病理学.基因重排;分子病理学.重排;分子病理学试验.基因重排;分子病理学试验.重排;分子病理学试验类.重排;基因重排;重排 分子病理学;分子病理学试验 印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释 叙述;叙述性文字;报告;报告型;文字叙述;文本叙述型;文本描述;文本描述型 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 血;血液 遗传基因;遗传因子;吉恩;生物基因

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