Version 2.78

Term Description

This term was created for, but is not limited in use to, the Vysis BCL2 Break Apart FISH Probe Kit, which is intended to detect chromosomal rearrangements at the BCL2 locus on chromosome region 18q21.
Source: Regenstrief LOINC

Part Descriptions

LP19775-3   BCL2 gene rearrangements
The BCL2 gene (B-cell CLL/lymphoma 2) [HGNC Gene ID:990] is located on chromosome 18q21.3. This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008] [NCBI Gene ID:596] Source: National Center for Biotechnology Information (NCBI) Gene

LP62864-1   FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, FISH

Fully-Specified Name

Component
BCL2 gene rearrangements
Property
PrThr
Time
Pt
System
Bld/Tiss
Scale
Ord
Method
FISH

Additional Names

Short Name
BCL2 gene Rear Bld/T Ql FISH
Display Name
BCL2 rearrangements FISH Ql (Bld/Tiss)
Consumer Name Alpha Get Info
BCL2 rearrangements, Blood or tissue specimen

Example Answer List: LL744-4

Source: Regenstrief Institute
Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
MOLPATH.REARRANGE
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.73
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common Test Rank Get Info
6530

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Reordenamientos del gen BCL2:PrThr:Punto temporal:Sangre o tejido:Ord:Hibridación in situ fluoresente (FISH)
es-MX Spanish (Mexico) Reordenamientos del gen BCL2:Presencia o umbral:Punto temporal:Sangre o tejido:Ordinal:Hibridación fluorescente in situ (FISH)
et-EE Estonian (Estonia) BCL2 geeni muudatused:PrThr:Pt:B/Tis:Ord:FISH
Synonyms: Järgarvuline Juhuslik Kude Veri Veri või koematerjal
fr-FR French (France) BCL2 gène réarrangements:Présence/Seuil:Ponctuel:Sang/Tissu:Qualitatif:FISH
it-IT Italian (Italy) BCL2, riarrangiamenti gene:PrThr:Pt:Sangue/Tess:Ord:FISH
Synonyms: Ibridazione in situ fluorescente (FISH) Patologia molecolare Presenza o Soglia Punto nel tempo (episodio) Riarrangiamenti gene BCL2 Riarrangiamento genico Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL Dutch (Netherlands) BCL2-genherschikking:aanwezigheid:moment:bloed of weefsel:ordinaal:FISH
Synonyms: BCL2 gen translocaties
tr-TR Turkish (Turkey) BCL2 geni yeniden düzenlenmeler:MevcEşik:Zmlı:Kan/Dk:Srl:FISH
Synonyms: Mevcut
zh-CN Chinese (China) BCL2 基因重排:存在情况或阈值:时间点:全血/组织:序数型:FISH
Synonyms: BCL2 基因重排（重组）;B 细胞 CLL;B 细胞慢性淋巴细胞白血病;慢性 B 淋巴细胞白血病;淋巴瘤 2;BCL-2;B-细胞白血病/淋巴瘤 2;B细胞白血病/淋巴瘤2;BCL-2 基因重排 BCL-2;B-细胞白血病/淋巴瘤 2;B细胞白血病/淋巴瘤2 Fluorescent in situ hybridization;荧光原位杂交 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 全血或组织;血液/组织;血液或组织 分子病理学.基因重排;分子病理学.重排;分子病理学试验.基因重排;分子病理学试验.重排;分子病理学试验类.重排;基因重排;重排 分子病理学;分子病理学试验 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 血;血液 遗传基因;遗传因子;吉恩;生物基因

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