78219-3
MLL gene rearrangements [Presence] in Blood or Tissue by FISH
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Term Description
This term was created for, but is not limited in use to, the Vysis LSI MLL Dual Color, Break Apart Rearrangement Probe Kit, intended for use in identifying MLL gene arrangements on chromosome region 11q23.
Part Descriptions
LP33228-5 MLL gene rearrangements
The MLL gene (lysine (K)-specific methyltransferase 2A) [HGNC Gene ID: 7132] is located on chromosome 11q23. This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010] [NCBI Gene ID:4297]
Source: National Center for Biotechnology Information (NCBI) Gene
LP62864-1 FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia,
FISH
LOINC Names Get Info
- Fully-Specified Name
- MLL gene rearrangements:
PrThr: Pt: Bld/Tiss: Ord: FISH - Long Common Name
- MLL gene rearrangements [Presence] in Blood or Tissue by FISH
- Short Name
- MLL gene Rear Bld/T Ql FISH
- Display Name
- MLL gene rearrangements FISH Ql (Bld/Tiss)
- Consumer Name Alpha Get Info
- MLL gene rearrangements, Blood or tissue specimen
Part Model Get Info
Example Answer List: LL744-4
Source: Regenstrief Institute| Answer | Code | Score | Answer ID |
|---|---|---|---|
| Detected | LA11882-0 | ||
| Not detected | LA11883-8 |
Basic Attributes
- Class
- MOLPATH.REARRANGE
- Type
- Laboratory
- First Released
- Version 2.54
- Last Updated
- Version 2.61 (MIN)
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Gen MLL přestavba: |
| el-GR | Greek (Greece) | Γονιδιακές αναδιατάξεις MLL: Synonyms: MOLPATH MOLPATH.REARRANGE Ord PrThr Pt Αίμα Αίμα/Ιστός Γονιδιακές αναδιατάξεις MLL Γονίδιο Γονίδιο MLL Ιστός Φθορίζουσα υβριδοποίηση in situ |
| es-ES | Spanish (Spain) | Reagrupamientos gen MLL: |
| es-MX | Spanish (Mexico) | Reordenamientos del gen MLL: |
| et-EE | Estonian (Estonia) | MLL geeni muudatused: Synonyms: Järgarvuline Juhuslik Kude Veri Veri või koematerjal |
| fr-FR | French (France) | MLL gène réarrangements: |
| it-IT | Italian (Italy) | MLL, riarrangiamenti gene: Synonyms: Gene MLL Ibridazione in situ fluorescente (FISH) Patologia molecolare Presenza o Soglia Punto nel tempo (episodio) Riarrangiamenti gene MLL Riarrangiamento genico Sangue Sangue o Tessuto Tessuto & |
| nl-NL | Dutch (Netherlands) | MLL genherschikking: Synonyms: MLL gen MLL gentranslocaties |
| pl-PL | Polish (Poland) | MLL gen rearanżacje: Synonyms: fluorescencyjna hybrydyzacja in situ Gen MLL Rearanżacje genu MLL |
| tr-TR | Turkish (Turkey) | MLL geni yeniden düzenlemeler: Synonyms: Mevcut |
| zh-CN | Chinese (China) | MLL 基因重排: Synonyms: ALL1 ALL-1 ALL-1; |
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LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://