78233-4

Cells.ALK gene rearrangements/Cells counted in Blood or Tissue by FISH

Active

Part Descriptions

LP190802-1 Cells.ALK gene rearrangements
The ALK gene (anaplastic lymphoma receptor tyrosine kinase) [HGNC Gene ID: 427] is located on chromosome 2p23. This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011] [NCBI Gene ID: 238] Source: National Center for Biotechnology Information (NCBI) Gene

LP62864-1 FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, FISH

LOINC Names Get Info

Fully-Specified Name: Cells.ALK gene rearrangements/Cells counted:NFr:Pt:Bld/Tiss:Qn:FISH
Long Common Name: Cells.ALK gene rearrangements/Cells counted in Blood or Tissue by FISH
Short Name: Cells.ALK rear/Cells cnt NFr Bld/T FISH
Display Name: Cells.ALK rearrangements/Cells counted FISH (Bld/Tiss)
Consumer Name Alpha Get Info: Cells.ALK Rearrangements/Cells Counted, Blood or tissue specimen

Part Model Get Info

Component
Cells.ALK gene rearrangements/Cells counted
LP285253-3
- Analyte
  Cells.ALK gene rearrangements/Cells counted
  LP285253-3
  - Component Numerator
    Cells.ALK gene rearrangements
    LP190802-1
    - Component Numerator Core
      Cells.ALK gene rearrangements
      LP190802-1
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    Cells counted
    LP190810-4
    - Component Denominator Core
      Cells counted
      LP190810-4
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
NFr
LP6838-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Bld/Tiss
LP7061-7
- System Core
  Bld/Tiss
  LP7061-7
- Super System
  NULL
Scale
Qn
LP7753-9
Method
FISH
LP62864-1

Basic Attributes

Class: MOLPATH.REARRANGE
Type: Laboratory
First Released: Version 2.54
Last Updated: Version 2.61 (MIN)
Order vs. Observation: Observation

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Buňky.gen ALK přestavba/buňky spočítané:Početní podíl:Časový bod:Krev/tkáň:Kvantitativní:Fluorescenční in situ hybridizace (FISH)
el-GR	Greek (Greece)	Κύτταρα.Γονιδιακές αναδιατάξεις ALK/Μετρηθέντα κύτταρα:NFr:Pt:Αίμα/Ιστός:Qn:Φθορίζουσα υβριδοποίηση in situ Synonyms: MOLPATH MOLPATH.REARRANGE NFr Pt Qn Αίμα Αίμα/Ιστός Γονιδιακές αναδιατάξεις ALK Γονίδιο Γονίδιο ALK Ιστός Κύτταρα Κύτταρα.Γονιδιακές αναδιατάξεις ALK Μετρηθέντα κύτταρα Φθορίζουσα υβριδοποίηση in situ
es-ES	Spanish (Spain)	Reordenamiento del gen ALK/Contaje celular:Fracción numérica:Punto temporal:Sangre o tejido:Qn:Hibridación in situ fluoresente (FISH) Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Células Reordenamientos del gen ALK / Células contadas:Fracción numérica:Punto temporal:Sangre o tejido:Cuantitativo:Hibridación fluorescente in situ (FISH)
fr-FR	French (France)	ALK gène réarrangements/cellules comptées:Fraction de nombres:Ponctuel:Sang/Tissu:Numérique:FISH
it-IT	Italian (Italy)	Cellule. Riarrangiamenti del gene ALK/Cellule contate:NFr:Pt:Sangue/Tess:Qn:FISH Synonyms: Frazione numerica Gene ALK Ibridazione in situ fluorescente (FISH) Patologia molecolare Punto nel tempo (episodio) Riarrangiamento genico Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL	Dutch (Netherlands)	cellen.ALK-genherschikking/getelde cellen:getalsfractie:moment:bloed of weefsel:kwantitatief:FISH Synonyms: ALK-gentranslocaties cellen.ALK gen translocaties
pl-PL	Polish (Poland)	Komórki.ALK gen rearanżacje/zliczone komórki:frakcja liczbowa:punkt w czasie:krew lub tkanka:ilościowy:FISH Synonyms: fluorescencyjna hybrydyzacja in situ Gen ALK Komórki z rearanżacjami genu ALK Rearanżacje genu ALK
tr-TR	Turkish (Turkey)	Hücreler.ALK geni yeniden düzenleme/Hücreler sayılan:SayFr:Zmlı:Kan/Dk:Kant:FISH
zh-CN	Chinese (China)	细胞.ALK 基因重排/已计数的细胞:计数型分数:时间点:全血/组织:定量型:FISH Synonyms: ALK 基因重排（重组） Fluorescent in situ hybridization;荧光原位杂交全血或组织;血液/组织;血液或组织分子病理学.基因重排;分子病理学.重排;分子病理学试验.基因重排;分子病理学试验.重排;分子病理学试验类.重排;基因重排;重排分子病理学;分子病理学试验可用数量表示的;定量性;数值型;数量型;连续数值型标尺所计数的细胞;计数细胞;所计数细胞;已计数细胞所计数细胞;已计数过细胞;已计数细胞;已计过数细胞数量型分数;数量或计数型分数;数量型分数或计数型分数时刻;随机;随意;瞬间未作说明的组织;组织;组织 & 涂片细胞.ALK 基因重排（重组）细胞含量;细胞性;细胞性质;细胞构成;细胞类血;血液遗传基因;遗传因子;吉恩;生物基因间变型淋巴瘤激酶间变性淋巴瘤激酶（anaplastic lymphoma kinase，ALK）

Example Units

Unit	Source
%	Example UCUM Units

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=78233-4

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.