78245-8

MYB gene deletion [Presence] in Blood or Tissue by FISH

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Term Description

This term was created for, but is not limited in use to, the Vysis MYB SpectrumAqua FISH Probe Kit, which is intended to detect deletion of the MYB gene located within the 6q23 chromosome region.

Part Descriptions

LP188999-9 MYB gene
Chromosome 6q23 deletion, which involves the MYB gene, is associated with chronic lymphocytic leukemia (CLL), acute lymphoblastic leukemia (ALL), B-cell small lymphocytic lymphoma, non-Hodgkin lymphoma, and multiple myeloma. Approximately 5% of patients with CLL were found to have the 6q23 deletion. PMID: 18949612 Deletion of the MYB gene may play a role in tumorigenesis since it is involved in transcriptional repression.[NCBI Gene ID:4602] Source: Regenstrief LOINC

LP62864-1 FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, FISH

LOINC Names Get Info

Fully-Specified Name: MYB gene deletion:PrThr:Pt:Bld/Tiss:Ord:FISH
Long Common Name: MYB gene deletion [Presence] in Blood or Tissue by FISH
Short Name: MYB Del Bld/T Ql FISH
Display Name: MYB gene del FISH Ql (Bld/Tiss)
Consumer Name Alpha Get Info: MYB gene deletion analysis, Blood or tissue specimen

Part Model Get Info

Component
MYB gene deletion
LP229071-8
- Analyte
  MYB gene deletion
  LP229071-8
  - Component Numerator
    MYB gene deletion
    LP229071-8
    - Component Numerator Core
      MYB gene
      LP188999-9
    - Component Numerator Core Suffix
      deletion
      LP29253-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Bld/Tiss
LP7061-7
- System Core
  Bld/Tiss
  LP7061-7
- Super System
  NULL
Scale
Ord
LP7751-3
Method
FISH
LP62864-1

Example Answer List: LL744-4

Source: Regenstrief Institute

Answer	Code	Score	Answer ID
Detected			LA11882-0
Not detected			LA11883-8

Basic Attributes

Class: MOLPATH.DEL
Type: Laboratory
First Released: Version 2.54
Last Updated: Version 2.61 (MIN)
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Gen MYB delece:Přítomnost nebo práh:Časový bod:Krev/tkáň:Ordinální:Fluorescenční in situ hybridizace (FISH)
el-GR	Greek (Greece)	Γονίδιο MYB διαγραφή:PrThr:Pt:Αίμα/Ιστός:Ord:Φθορίζουσα υβριδοποίηση in situ Synonyms: MOLPATH MOLPATH.DEL Ord PrThr Pt Αίμα Αίμα/Ιστός Γονίδιο Γονίδιο MYB διαγραφή Ιστός Φθορίζουσα υβριδοποίηση in situ
es-ES	Spanish (Spain)	Gen MYB Deleción:PrThr:Punto temporal:Sangre o tejido:Ord:Hibridación in situ fluoresente (FISH)
es-MX	Spanish (Mexico)	Deleción del gen MYB:Presencia o umbral:Punto temporal:Sangre o tejido:Ordinal:Hibridación fluorescente in situ (FISH)
fr-FR	French (France)	MYB gène délétion:Présence/Seuil:Ponctuel:Sang/Tissu:Qualitatif:FISH
it-IT	Italian (Italy)	MYB, gene Delezione:PrThr:Pt:Sangue/Tess:Ord:FISH Synonyms: Delezione genetica Gene MYB Ibridazione in situ fluorescente (FISH) Patologia molecolare Presenza o Soglia Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL	Dutch (Netherlands)	MYB-gen deletie:aanwezigheid:moment:bloed of weefsel:ordinaal:FISH Synonyms: MYB gen
pl-PL	Polish (Poland)	MYB gen delecja:granica wykrywalności:punkt w czasie:krew lub tkanka:uporządkowany:FISH Synonyms: fluorescencyjna hybrydyzacja in situ Gen MYB
tr-TR	Turkish (Turkey)	MYB geni delesyon:MevcEşik:Zmlı:Kan/Dk:Srl:FISH Synonyms: Mevcut
zh-CN	Chinese (China)	MYB 基因缺失:存在情况或阈值:时间点:全血/组织:序数型:FISH Synonyms: Fluorescent in situ hybridization;荧光原位杂交 Myb 原癌基因蛋白;转录激活因子 Myb;转录活化子 Myb;转录激活剂 Myb;V-myb 禽成髓细胞增多症（禽成髓细胞性白血病、鸟类成髓细胞血症、鸟类成髓细胞性白血病）病毒癌基因同源物;Myb proto-oncogene protein;transcriptional activator Myb;V-myb avian myeloblastosis viral oncogene homolog;Cmyb;c-myb;c-myb_CDS;efg 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型全血或组织;血液/组织;血液或组织分子病理学.基因缺失;分子病理学.缺失;分子病理学试验.基因缺失;分子病理学试验.缺失;分子病理学试验类.缺失;基因缺失;缺失分子病理学;分子病理学试验存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）时刻;随机;随意;瞬间未作说明的组织;组织;组织 & 涂片染色体缺失;染色体区带缺失;基因缺失;缺损;基因缺损;基因删除;删除;基因丢失血;血液遗传基因;遗传因子;吉恩;生物基因

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CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=78245-8

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.