Version 2.77

Term Description

This term was created for, but is not limited in use to, the Vysis MYB SpectrumAqua FISH Probe Kit, which is intended to detect deletion of the MYB gene located within the 6q23 chromosome region.
Source: Regenstrief LOINC

Part Descriptions

LP188999-9   MYB gene
Chromosome 6q23 deletion, which involves the MYB gene, is associated with chronic lymphocytic leukemia (CLL), acute lymphoblastic leukemia (ALL), B-cell small lymphocytic lymphoma, non-Hodgkin lymphoma, and multiple myeloma. Approximately 5% of patients with CLL were found to have the 6q23 deletion. PMID: 18949612 Deletion of the MYB gene may play a role in tumorigenesis since it is involved in transcriptional repression.[NCBI Gene ID:4602] Source: Regenstrief LOINC

LP62864-1   FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, FISH

Fully-Specified Name

Component
MYB gene deletion
Property
PrThr
Time
Pt
System
Bld/Tiss
Scale
Ord
Method
FISH

Additional Names

Short Name
MYB Del Bld/T Ql FISH
Display Name
MYB gene del FISH Ql (Bld/Tiss)
Consumer Name Alpha Get Info
MYB gene deletion analysis, Blood or tissue specimen

Example Answer List: LL744-4

Source: Regenstrief Institute
Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
MOLPATH.DEL
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.61
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Gen MYB Deleción:PrThr:Punto temporal:Sangre o tejido:Ord:Hibridación in situ fluoresente (FISH)
es-MX Spanish (Mexico) Deleción del gen MYB:Presencia o umbral:Punto temporal:Sangre o tejido:Ordinal:Hibridación fluorescente in situ (FISH)
fr-FR French (France) MYB gène délétion:Présence/Seuil:Ponctuel:Sang/Tissu:Qualitatif:FISH
it-IT Italian (Italy) MYB, gene Delezione:PrThr:Pt:Sangue/Tess:Ord:FISH
Synonyms: Delezione genetica Gene MYB Ibridazione in situ fluorescente (FISH) Patologia molecolare Presenza o Soglia Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL Dutch (Netherlands) MYB-gen deletie:aanwezigheid:moment:bloed of weefsel:ordinaal:FISH
Synonyms: MYB gen
tr-TR Turkish (Turkey) MYB geni delesyon:MevcEşik:Zmlı:Kan/Dk:Srl:FISH
Synonyms: Mevcut
zh-CN Chinese (China) MYB 基因 缺失:存在情况或阈值:时间点:全血/组织:序数型:FISH
Synonyms: Fluorescent in situ hybridization;荧光原位杂交 Myb 原癌基因蛋白;转录激活因子 Myb;转录活化子 Myb;转录激活剂 Myb;V-myb 禽成髓细胞增多症(禽成髓细胞性白血病、鸟类成髓细胞血症、鸟类成髓细胞性白血病)病毒癌基因同源物;Myb proto-oncogene protein;transcriptional activator Myb;V-myb avian myeloblastosis viral oncogene homolog;Cmyb;c-myb;c-myb_CDS;efg 依次型;分类顺序型;定性的;序数型(或称等级型);性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 全血或组织;血液/组织;血液或组织 分子病理学.基因缺失;分子病理学.缺失;分子病理学试验.基因缺失;分子病理学试验.缺失;分子病理学试验类.缺失;基因缺失;缺失 分子病理学;分子病理学试验 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况(存在、存在与否、是否存在)或阈值(界值、界限、阀值、临界值) 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 染色体缺失;染色体区带缺失;基因缺失;缺损;基因缺损;基因删除;删除;基因丢失 血;血液 遗传基因;遗传因子;吉恩;生物基因

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