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Part Description

LP201688-1   N6-Acetyl-L-lysine
N-acetyl-lysine is an acetylated amino acid. Post-translational lysine-acetylation is one of two major modifications of lysine residues in various proteins. Acetylation of specific lysine residues in the N-terminal domains of core histones is a biochemical marker of active genes. Acetylation is now known to play a major role in eukaryotic transcription. Specifically, acetyltransferase enzymes that act on particular lysine side chains of histones and other proteins are intimately involved in transcriptional activation. By modifying chromatin proteins and transcription-related factors, these acetylases are believed to regulate the transcription of many genes. The best-characterized mechanism is acetylation, catalyzed by histone acetyltransferase (HAT) enzymes. HATs function enzymatically by transferring an acetyl group from acetyl-coenzyme A (acetyl-CoA) to the -amino group of certain lysine side chains within a histone's basic N-terminal tail region. Within a histone octamer, these regions extend out from the associated globular domains, and in the context of a nucleosome, they are believed to bind the DNA through charge interactions (positively charged histone tails associated with negatively charged DNA) or mediate interactions between nucleosomes. Lysine acetylation, which neutralizes part of a tail region's positive charge, is postulated to weaken histone-DNA or nucleosome-nucleosome interactions and/or signal a conformational change, thereby destabilizing nucleosome structure or arrangement and giving other nuclear factors, such as the transcription complex, more access to a genetic locus. In agreement with this is the fact that acetylated chromatin has long been associated with states of transcriptional activation. Specific recognition of N-acetyl-lysine is a conserved function of all bromodomains found in different proteins, recognized as an emerging intracellular signaling mechanism that plays critical roles in regulating gene transcription, cell-cycle progression, apoptosis, DNA repair, and cytoskeletal organization. PMID: 9169194 PMID: 10827952 PMID: 17340003 PMID: 16247734 PMID: 9478947 PMID: 10839822 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database,

LOINC Names Get Info

Fully-Specified Name
N6-Acetyl-L-lysine:SCnc:Pt:Ser/Plas:Qn:
Long Common Name
N6-Acetyl-L-lysine [Moles/volume] in Serum or Plasma
Short Name
N6-Ac-L-lys SerPl-sCnc
Display Name
N6-Acetyl-L-lysine [Moles/Vol]
Consumer Name Alpha Get Info
N6-Acetyl-L-lysine, Blood

Part Model Get Info

  • Component
    N6-Acetyl-L-lysine
    LP201688-1
    • Analyte
      N6-Acetyl-L-lysine
      LP201688-1
      • Component Numerator
        N6-Acetyl-L-lysine
        LP201688-1
        • Component Numerator Core
          N6-Acetyl-L-lysine
          LP201688-1
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    SCnc
    LP6860-3
  • Time
    Pt
    LP6960-1
  • System
    Ser/Plas
    LP7576-4
    • System Core
      Ser/Plas
      LP7576-4
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.56 (MIN)
Change Reason
Changed Class from CHEM.ESOTERIC to CHEM and added Esoteric tag for more flexibility
Order vs. Observation
Observation

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)N6-acetyl-L-lysin:Látková koncentrace:Časový bod:Sérum/plazma:Kvantitativní:
el-GRGreek (Greece)Ν6-ακετυλο-L-λυσίνη:SCnc:Pt:Ορός/Πλάσμα:Qn:
Synonyms: CHEM Pt Qn SCnc Λυσίνη Ν6-ακετυλο-L-λυσίνη Ορός Ορός/Πλάσμα Πλάσμα
es-ESSpanish (Spain)N6-Acetil-L-lisina:Concentración de sustancia:Punto temporal:Suero o Plasma:Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)N6-acetil-L-lisina:Concentración de sustancias:Punto temporal:Suero o Plasma:Cuantitativo:
fr-FRFrench (France)N6-acétyl-L-lysine:Moles/Volume:Ponctuel:Sérum/Plasma:Numérique:
it-ITItalian (Italy)N6-Acetil-L-lisina:SCnc:Pt:Siero/Plasma:Qn:
Synonyms: Chimica Concentrazione di Sostanza Plasma Punto nel tempo (episodio) Siero Siero o Plasma
nl-NLDutch (Netherlands)N6-acetyl-L-lysine:mol/volume:moment:serum of plasma:kwantitatief:
pl-PLPolish (Poland)N6-acetylo-L-lizyna:stężenie molowe:punkt w czasie:surowica lub osocze:ilościowy:
Synonyms: N-acetylo-L-lizyna
tr-TRTurkish (Turkey)N6-Astil-L-lizin:SubKons:Zmlı:Ser/Plaz:Kant:
zh-CNChinese (China)N6-乙酰-L-赖氨酸:物质的量浓度:时间点:血清/血浆:定量型:
Synonyms: 2,6-二氨基已酸;Lys;氨基已氨酸;溶细胞素 N6-乙酰基-L-赖氨酸 克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 左 左侧 左侧（Left，L） 时刻;随机;随意;瞬间 血清或血浆

Example Units

UnitSource
umol/LExample UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=79578-1