79712-6
HLA-A*31:01 [Presence] in Blood or Tissue
Active
Part Description
LP203038-7 HLA-A*31:01
The human leukocyte antigen B (HLA-B; [HGNC Gene ID: 4932]) plays an important role in how the immune system recognizes and responds to pathogens. HLA-B belongs to a class of molecules that are found on the surface of most cells. These molecules are responsible for presenting peptides to immune cells. Peptides derived from normal human proteins are recognized as such, whereas foreign peptides derived from pathogens trigger an immune response. Antiepileptics with an aromatic ring, for example carbamazepine and phenytoin, interact with HLA-B*31:01 and alter the repertoire of self peptides that are presented to T lymphocytes, which activates an immune reaction known as Stevens-Johnson syndrome or toxic epidermal necrolysis. PMID: 23695185 PMID: 25099164 See https://www.pharmgkb.org/gene/PA35056 for more information and dosing guidelines for drugs impacted by HLA-B genetic variation.
Source: Clinical Pharmacogenetics Implementation Consortium
Fully-Specified Name
- Component
- HLA-A*31:01
- Property
- PrThr
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Ord
- Method
Additional Names
- Short Name
- HLA-A*31:01 Bld/T Ql
- Display Name
- HLA-A*31:01 Ql (Bld/Tiss)
- Consumer Name Alpha Get Info
- HLA-A*31:01, Blood or tissue specimen
Preferred Answer List: LL360-9
Source: Regenstrief InstituteAnswer | Code | Score | Answer ID |
---|---|---|---|
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Basic Attributes
- Class
- MOLPATH.PHARMG
- Type
- Laboratory
- First Released
- Version 2.54
- Last Updated
- Version 2.56
- Change Reason
- The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
- Order vs. Observation
- Both
Member of these Panels
LOINC | Long Common Name |
---|---|
94855-4 | carBAMazepine hypersensitivity genotype panel - Blood or Tissue |
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | HLA-A*31: |
es-MX | Spanish (Mexico) | HLA-A * 31: |
fr-FR | French (France) | HLA-A*31: |
it-IT | Italian (Italy) | HLA-A*31: Synonyms: Farmacogenomica Patologia molecolare Presenza o Soglia Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & |
nl-NL | Dutch (Netherlands) | HLA-A*31: |
tr-TR | Turkish (Turkey) | HLA-A*31: Synonyms: Mevcut |
zh-CN | Chinese (China) | HLA-A*31: Synonyms: A 型 HLA 抗原; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=79712-6
Third Party Copyright
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LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright