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Term Description

The SLCO1B1 gene product functional interpretation is determined by the reporting lab and returned with the structured test results. The Preferred Answer list associated with this term is based on the Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for reporting SLCO1B1 gene product functional activity (phenotype). This specific interpretation would be considered a separate observation made by the lab in addition to the primary reported results (e.g., genotype) and it could be included with other assay-specific observations, which would ideally support the interpretation value.https://cpicpgx.org/resources.html

Part Description

LP202928-0   SLCO1B1 gene product functional interpretation
Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene [HGNC Gene ID: 2645]. Variations in the SLCO1B1 gene have been significantly associated with a marked increase in systemic exposure to simvastatin and risk of muscle toxicity. PMID: 24918167 The overall effect size and significance of this association are striking for simvastatin compared to other statins. Patients with variations in SLCO1B1 (a transporter of simvastatin) may require a lower simvastatin dose or an alternative statin as compared to patients who do not have this variant. See https://www.pharmgkb.org/gene/PA134865839 for more information and dosing guidelines for drugs impacted by SLCO1B1 genetic variation. Source: Clinical Pharmacogenetics Implementation Consortium

LOINC Names Get Info

Fully-Specified Name
SLCO1B1 gene product functional interpretation:Imp:Pt:Bld/Tiss:Ord:Molgen
Long Common Name
SLCO1B1 gene product functional interpretation in Blood or Tissue Qualitative by Molecular genetics method
Short Name
SLCO1B1 gene prod funct imp Bld/T
Display Name
SLCO1B1 gene product functional interpretation Molgen Ql (Bld/Tiss) [Interp]
Consumer Name Alpha Get Info
SLCO1B1 gene product Functional interpretation, Blood or tissue specimen

Part Model Get Info

  • Component
    SLCO1B1 gene product functional interpretation
    LP202928-0
    • Analyte
      SLCO1B1 gene product functional interpretation
      LP202928-0
      • Component Numerator
        SLCO1B1 gene product functional interpretation
        LP202928-0
        • Component Numerator Core
          SLCO1B1 gene product functional interpretation
          LP202928-0
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Imp
    LP6819-9
  • Time
    Pt
    LP6960-1
  • System
    Bld/Tiss
    LP7061-7
    • System Core
      Bld/Tiss
      LP7061-7
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Molgen
    LP6404-0

Preferred Answer List: LL3858-9

Source: Clinical Pharmacogenetics Implementation Consortium
AnswerCodeScoreAnswer ID
Increased functionLA25392-4
Normal functionLA25393-2
Decreased functionLA25395-7
Poor functionLA25394-0

Basic Attributes

Class
MOLPATH.PHARMG
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.67 (MAJ)
Order vs. Observation
Observation

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Produkt genu SLCO1B1 funkční interpretace:Interpretace:Časový bod:Krev/tkáň:Ordinální:Molekulární genetika
de-ATGerman (Austria)Synonyms: SLCO1B1-Genotypisierung
el-GRGreek (Greece)Λειτουργική ερμηνεία προϊόντος γονιδίου SLCO1B1:Imp:Pt:Αίμα/Ιστός:Ord:Μοριακή γενετική
Synonyms: Imp MOLPATH MOLPATH.PHARMG Ord Pt Αίμα Αίμα/Ιστός Γονίδιο Γονίδιο SLCO1B1 Ερμηνεία Ιστός Λειτουργική ερμηνεία προϊόντος γονιδίου SLCO1B1 Μοριακή γενετική
es-ESSpanish (Spain)Gen SLCO1B1 interpretación de la función del fármaco:Impresión/interpretación del estudio:Punto temporal:Sangre o tejido:Ord:Genética molecular
es-MXSpanish (Mexico)Interpretación funcional del producto del gen SLCO1B1:Impresión / interpretación del estudio:Punto temporal:Sangre o tejido:Ordinal:Genética molecular
fr-FRFrench (France)SLCO1B1 gène fonctionnement du produit génétique interprétation:Interprétation:Ponctuel:Sang/Tissu:Qualitatif:Biologie moléculaire
it-ITItalian (Italy)Interpretazione funzionale del gene SLCO1B1:Imp:Pt:Sangue/Tess:Ord:Molgen
Synonyms: Farmacogenomica Gene SLCO1B1 Genetica molecolare Impressione/interpretazione di studio Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NLDutch (Netherlands)SLCO1B1-gen product functionele interpretatie:interpretatie:moment:bloed of weefsel:ordinaal:moleculair genetisch onderzoek
Synonyms: molgen SLCO1B1 gen product functionele interpretatie
pl-PLPolish (Poland)Interpretacja funkcjonalna produktu genu SLCO1B1:ocena:punkt w czasie:krew lub tkanka:uporządkowany:genetyka molekularna
Synonyms: diagnostyka molekularna Gen SLCO1B1
tr-TRTurkish (Turkey)SLCO1B1 geni ürünü fonksiyonu yorumu:İzlnm:Zmlı:Kan/Dk:Srl:Molgen
zh-CNChinese (China)SLCO1B1 基因产物功能解释:印象:时间点:全血/组织:序数型:分子遗传学类实验室方法
Synonyms: SLCO1B1 基因产物功能（功能性、功能活性）解释（说明、阐释、诠释、解释说明） 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 全血或组织;血液/组织;血液或组织 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 判读;解释说明;说明;释义;阐明 印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 溶质载体有机阴离子转运蛋白家族成员 1B1 基因;Solute Carrier Organic Anion Transporter Family Member 1B1 gene 血;血液 遗传基因;遗传因子;吉恩;生物基因

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