LOINC
Version 2.73

80382-5Influenza virus A Ag [Presence] in Upper respiratory specimen by Rapid immunoassayActive

Term Description

This term was created for, but is not limited in use to, the Influenza A part of the bioMerieux bioNexia Influenza A+B test, which is intended for the qualitative detection and differentiation of Influenza type A and type B antigens in human nasopharyngeal samples. The results of the bioNexia assay should be read ten minutes after the sample is applied to the sample well.
Source: Regenstrief LOINC

Part Description

LP14239-5   Influenza virus A
Influenza viruses, from the family Orthomyxoviridae, are enveloped negative-strand RNA viruses with segmented genomes containing seven to eight gene segments. Of the five genera in the family, only influenza A virus (IAV), influenza B and C are medically relevant to humans. Aquatic birds harboring avian IAV are the likely natural reservoir for all known IAV subtypes and are probably the original source of all human pandemic IAV strains. IAV maintained in wild birds have been associated with stable host switch events to novel hosts, including most often to domestic poultry but also to horses, swine, toothed whales and humans. The influenza virus life cycle begins with the binding of viral HA to host cell receptors. Endocytosis and HA-mediated fusion of the viral and cellular membranes occurs. Viral ribonucleoprotein complexes are released into the cytoplasm, travel to the nucleus, then are replicated and transcribed by the viral polymerase complex. The new viruses are formed and bud when the newly formed ribonucleicprotein complexes and structural proteins reach the plasma membrane. Further research is needed to better understand how IAVs switch hosts and the viral genetic changes that underlie human adaptation. IAV causes respiratory infections in humans ranging from asymptomatic to fatal. Pandemics are attributed to "novel" viruses which possess a viral hemagglutinin (HA) to which humans do not have immunity. [PMID:20542248] [PMID:25812763]
Influenza viruses A and B are single-stranded RNA enveloped viruses belonging to the Orthomyxoviridae family. The symptoms of infection of Influenza A and B include fever, cough, sore throat, rhinorrhea, nasal congestion, headache, myalgia and malaise. Some patients may experience gastrointestinal symptoms including watery diarrhea, vomiting and abdominal pain. The influenza viruses spread rapidly in enclosed spaces with a documented rate of infection of 70% following a common source of exposure. Infection occurs in the respiratory epithelium in both the upper and lower respiratory tract, and the virus can be found in many specimen types, including nasal aspirates, nasal or nasopharyngeal swabs, throat swabs, sputum and tracheal aspirates. When infection rates reach epidemic proportions, hospitalization of children and elderly patients rises as does the mortality rates of elderly patients.(Manual of Clinical Microbiology, 11th edition, James H. Jorgensen; Karen C. Carroll; Guido Funke; Michael A Pfaller; Marie Louise Landry; Sandra S. Richter; David W. Warnock) Source: Regenstrief LOINC

Fully-Specified Name

Component
Influenza virus A Ag
Property
PrThr
Time
Pt
System
Respiratory.upper
Scale
Ord
Method
IA.rapid

Additional Names

Short Name
FLUAV Ag Upper resp Ql IA.rapid
Display Name
FLUAV Ag IA.rapid Ql (Upper resp)
Consumer Name Alpha
Influenza A (Flu A) antigen, Upper respiratory

Example Answer List LL744-4

Source: Regenstrief Institute

Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.54
Last Updated
Version 2.73
Change Reason
Release 2.70: SYSTEM: Updated from "Nph" to make the LOINC term consistent with the original intent to represent a manufacturer's test covering NPH washes and nose swabs, as well as to make it consistent across panel usage.; Previous Releases: Corrected System from "Nasopharynx", which is used for LOINC clinical terms, to "Nph", which is the form used for LOINC lab terms.; The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.; The EIA method, which was always intended to cover more than just enzyme-linked immunoassay and whose display name for the long common name has always been Immunoassay, was renamed IA in order to eliminate ambiguity about whether the method has a broader meaning than just enzyme-linked immunoassay. Likewise, EIA.rapid was renamed IA.rapid. These changes were approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common US Lab Results Rank
1303

Member of these Panels

LOINC Long Common Name
80381-7 Influenza virus A and B Ag panel - Upper respiratory specimen by Rapid immunoassay
97099-6 Influenza virus A and B and SARS-CoV-2 (COVID-19) Ag panel - Upper respiratory specimen by Rapid immunoassay
95942-9 Influenza virus A and B and SARS-CoV+SARS-CoV-2 (COVID-19) Ag panel - Upper respiratory specimen by Rapid immunoassay

Member of these Groups

LG32757-3 Influenza virus
LG34020-4 Influenza virus A Ag|PrThr|Sys:ANYResp

Language Variants Get Info

zh-CNChinese (China)
流感病毒 A 型 抗原:存在情况或阈值:时间点:呼吸道.上:序数型:免疫测定法.快速
nl-NLDutch (Netherlands)
Influenzavirus A Ag:aanwezigheid:moment:bovenste luchtwegen:ordinaal:immunoassay.sneltest
fr-FRFrench (France)
Influenza virus A Ag:Présence/Seuil:Ponctuel:Nasopharynx:Qualitatif:Immunoanalyse rapide
de-DEGerman (Germany)
Influenza-Virus A Ag:Nachweis oder Schwellenwert:Zeitpunkt:Respirationstrakt.oberer:Ordinal:Immunoassay.schnell
it-ITItalian (Italy)
Influenza A, virus , Ag:PrThr:Pt:Sistema respiratorio.superiore:Ord:IA.rapido
es-MXSpanish (Mexico)
Virus de la influenza A Ag:Presencia o umbral:Punto temporal:Nasofaringe:Ordinal:Inmunoensayo rápido
es-ESSpanish (Spain)
Virus Influenza A Antígeno:PrThr:Punto temporal:Muestra respiratoria de vías altas:Ord:IA.rapid

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=80382-5