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Term Description

Dried blood spot (DBS) specimens have been used for therapeutic drug monitoring (TDM) across several classes of drugs including antimicrobials, anticonvulsants and immunosuppressants. DBS specimens are useful for TDM in infants and children due to the small sample volume required. DBS specimens are also useful for outpatient TDM in adults who have been trained to collect their own DBS because most analytes are relatively stable in DBS and the DBS card does not require specialized transportation. PMID: 25204403

Part Description

LP21368-3   Sirolimus
Sirolimus, also known as rapamycin, is a macrolide compound that inhibits lymphocyte proliferation and is used as an immunosuppressant to prevent rejection in organ transplantation. It inhibits T-cell activation and proliferation by inhibiting the response to interleukin 2 (IL-2). Its mode of action differs from that of other immunosuppressants (SN Sehga, Clin Biochem, 31:335, 1998) most notably by not being a calcineurin inhibitor. Its inhibitory action is mediated via a cytosolic protein, FK-binding protein 12. Sirolimus is variably absorbed; levels need to monitored to achieve the therapeutic target while avoiding toxic levels. Sirolimus is marketed under the trade name Rapamune. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Sirolimus:MCnc:Pt:Bld.dot:Qn:
Long Common Name
Sirolimus [Mass/volume] in DBS
Short Name
Sirolimus DBS-mCnc
Display Name
Sirolimus (DBS) [Mass/Vol]
Consumer Name Alpha Get Info
Sirolimus, Dried blood spot

Part Model Get Info

  • Component
    Sirolimus
    LP21368-3
    • Analyte
      Sirolimus
      LP21368-3
      • Component Numerator
        Sirolimus
        LP21368-3
        • Component Numerator Core
          Sirolimus
          LP21368-3
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    MCnc
    LP6827-2
  • Time
    Pt
    LP6960-1
  • System
    Bld.dot
    LP21304-8
    • System Core
      Bld.dot
      LP21304-8
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
DRUG/TOX
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.61 (MIN)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Sirolimus:Hmotnostní koncentrace:Časový bod:Suchá krevní kapka (DBS):Kvantitativní:
el-GRGreek (Greece)Σιρόλιμους:MCnc:Pt:Bld.dot:Qn:
Synonyms: Bld.dot DRUG/TOX MCnc Pt Qn Αίμα Σιρόλιμους
es-ESSpanish (Spain)Sirolimus:Concentración de masa:Punto temporal:gota de sangre (papel de filtro):Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Sirolimus:Concentración de masa:Punto temporal:DBS:Cuantitativo:
et-EEEstonian (Estonia)Siroliimus:MCnc:Pt:Vereplekk:Qn:
Synonyms: Juhuslik Kvantitatiivne Veri
fr-CAFrench (Canada)Sirolimus:Concentration de masse:Temps ponctuel:Sang sur papier filtre:Quantitatif:
fr-FRFrench (France)Sirolimus:Masse/Volume:Ponctuel:Sang buvard:Numérique:
fr-BEFrench (Belgium)Sirolimus:Concentration de masse:Temps ponctuel:Sang sur papier filtre:Quantitatif:
it-ITItalian (Italy)Sirolimus:MCnc:Pt:Sangue.su carta da filtro:Qn:
Synonyms: Concentrazione di Massa Livelli farmacologici e tossicologia Punto nel tempo (episodio) Sangue Spot sangue secco
nl-NLDutch (Netherlands)sirolimus:massa/volume:moment:gedroogde bloedspot:kwantitatief:
ru-RURussian (Russian Federation)Сиролимус:МассКонц:ТчкВрм:Кр.Сух.капл:Колич:
Synonyms: Количественный Кровь Кровь сухая капля Массовая концентрация Рапамицин Точка во времени;Момент
tr-TRTurkish (Turkey)Sirolimus:KütlKons:Zmlı:Kan.nokta:Kant:
zh-CNChinese (China)西罗莫司:质量浓度:时间点:全血.斑点:定量型:
Synonyms: 全血斑点(滤纸);滤纸;血液.斑点;血液斑点(滤纸) 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 毒品 毒品类 水平;浓度;质量浓度(单位体积) 瑞帕霉素;雷帕霉素 药品类 药物 药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类 药物类 血;血液

Example Units

UnitSource
ug/LExample UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=80548-1