80691-9

HIV 1 proviral DNA integrase gene mutations detected [Identifier] in Blood mononuclear cells by Sequencing

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Term Description

This test is designed to provide HIV-1 antiretroviral (ARV) drug resistance data when standard resistance testing cannot be performed due to inadequate plasma viral load. The assay interrogates the proviral DNA in infected cells using sequencing methods to provide a list of mutations and susceptibility information based on those mutations.
Source: Regenstrief LOINC

Part Descriptions

LP150045-5 Sequencing
Sequencing is a method used to determine the sequence of individual genes, larger genetic regions (i.e. clusters of genes or operons), full chromosomes or entire genomes. Historically, most sequencing has been performed using the chain termination method developed by Frederick Sanger in 1977. PMID: 271968 Sequencing technologies have improved dramatically, making them cheaper, faster, and more accurate. Next-generation sequencing (NGS), also known as high-throughput sequencing, deep sequencing, and second-generation sequencing, is a type of technology that uses parallel sequencing of multiple small fragments of DNA to determine sequence. This "high-throughput" technology has increased the speed and amount of DNA sequenced at a significantly reduced cost. PMID: 18576944 Several NGS platforms (ie, sequencing instruments and associated reagents) have been developed. Third-generation sequencing is another methodology currently under development that uses parallel sequencing similar to NGS. In contrast to NGS, third-generation sequencing uses single DNA molecules rather than amplified DNA as a template. PMID: 20858600 Source: Regenstrief LOINC

LP207655-4 HIV 1 proviral DNA integrase gene
HIV Integrase is the viral enzyme system responsible for incorporating viral DNA into host DNA resulting in chronic infection. Source: LOINC partner 1

Fully-Specified Name

Component: HIV 1 proviral DNA integrase gene mutations detected
Property: Prid
Time: Pt
System: Bld MC
Scale: Nom
Method: Sequencing

Additional Names

Short Name: HIV1 proviral DNA IN Mut Det Bld MC Seq
Display Name: HIV 1 proviral DNA integrase gene mutations detected Sequencing Nom (Bld MC)
Consumer Name Alpha Get Info: HIV 1 Proviral DNA Integrase gene variant analysis, Blood

Example Answer List: LL3697-1

Source: Laboratory Corporation of America

Answer	Code	Score	Answer ID
V31I HIV mutation in the integrase (IN) coding region			LA19757-6
V72I HIV mutation in the integrase (IN) coding region			LA24443-6
T97A HIV mutation in the integrase (IN) coding region			LA24440-2
L101I HIV mutation in the integrase (IN) coding region			LA24444-4
V113I HIV mutation in the integrase (IN) coding region			LA24445-1
S119S/T HIV mutation in the integrase (IN) coding region			LA24442-8
T124A HIV mutation in the integrase (IN) coding region			LA24446-9
E138D HIV mutation in the integrase (IN) coding region			LA24447-7
Y143R HIV mutation in the integrase (IN) coding region			LA24441-0
E157E/Q HIV mutation in the integrase (IN) coding region			LA24449-3
K188R HIV mutation in the integrase (IN) coding region			LA24450-1
G193E HIV mutation in the integrase (IN) coding region			LA24451-9
V201I HIV mutation in the integrase (IN) coding region			LA24452-7
V234L HIV mutation in the integrase (IN) coding region			LA24453-5
D288N HIV mutation in the integrase (IN) coding region			LA24454-3

Basic Attributes

Class: ABXBACT
Type: Laboratory
First Released: Version 2.56
Last Updated: Version 2.73
Order vs. Observation: Both
Common Test Rank Get Info: 19228

Language Variants Get Info

Tag	Language	Translation
es-ES	Spanish (Spain)	Gen de la integrasa del ADN proviral del VIH 1 Detección de mutaciones:Presencia o identidad:Punto temporal:Celulas Mononucleares sanguíneas:Nom:Secuenciación
es-MX	Spanish (Mexico)	Se detectaron mutaciones en el gen de la integrasa del ADN proviral del VIH 1:Presencia o identidad:Punto temporal:Células mononucleares de sangre:Nominal:Secuenciación
fr-FR	French (France)	VIH-1 ADN proviral gène intégrase mutations détectées:Identification:Ponctuel:Cellules mononucléées de sang périphérique:Résultat nominal:Séquençage
it-IT	Italian (Italy)	HIV 1 proviral,DNA gene delle integrasi, mutazioni identificate:Prid:Pt:Cellule mononucleate da sangue intero:Nom:Sequenziamento Synonyms: Presenza o Identità Punto nel tempo (episodio) Sangue Suscettibilità agli antibiotici
nl-NL	Dutch (Netherlands)	HIV 1 proviraal DNA integrase gen gedetecteerde mutaties:identificator:moment:mononucleaire cellen in bloed:nominaal:sequencing
zh-CN	Chinese (China)	HIV 1 型前病毒 DNA 整合酶基因已检出的突变:存在与否或特征标识:时间点:全血单个核细胞:名义型:序列测定 Synonyms: Ⅰ AIDS;AIDS 病毒;人类免疫缺陷病毒;人类免疫缺陷病毒（Human immunodeficiency virus，HIV）;爱滋病;艾滋病;艾滋病病毒;获得性免疫缺陷综合征;获得性免疫缺陷综合征（Acquired Immure Deficiency Syndrome，AIDS，艾滋病） HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型）前病毒;人类免疫缺陷病毒 1 型前病毒;人类免疫缺陷病毒 I 型前病毒 HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型）前病毒 DNA HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型）前病毒 DNA 整合酶（IN）基因 HIV1;HTLV 3;HTLV III;人类免疫缺陷病毒 1 型;人类免疫缺陷病毒 I 型;HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型） I 全血（血液、血）单个核细胞（单核细胞、MC）;全血标本（样品、样本、试样）单个核细胞分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答去氧核糖核酸;脱氧核糖核酸;脱氧核糖核酸（Deoxyribonucleic acid，DNA）存在;存在与否;特征标识;身份;身份标识已发现的突变序列分析;测序抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类时刻;随机;随意;瞬间突变突变类;基因突变血;血液遗传基因;遗传因子;吉恩;生物基因

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