80692-7

HIV 1 proviral DNA reverse transcriptase and protease gene mutations detected [Identifier] in Blood mononuclear cells by Sequencing

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Term Description

This test is designed to provide HIV-1 antiretroviral (ARV) drug resistance data when standard resistance testing cannot be performed due to inadequate plasma viral load. The assay interrogates the proviral DNA in infected cells using sequencing methods to provide a list of mutations and susceptibility information based on those mutations.

Part Description

LP150045-5 Sequencing
Sequencing is a method used to determine the sequence of individual genes, larger genetic regions (i.e. clusters of genes or operons), full chromosomes or entire genomes. Historically, most sequencing has been performed using the chain termination method developed by Frederick Sanger in 1977. PMID: 271968 Sequencing technologies have improved dramatically, making them cheaper, faster, and more accurate. Next-generation sequencing (NGS), also known as high-throughput sequencing, deep sequencing, and second-generation sequencing, is a type of technology that uses parallel sequencing of multiple small fragments of DNA to determine sequence. This "high-throughput" technology has increased the speed and amount of DNA sequenced at a significantly reduced cost. PMID: 18576944 Several NGS platforms (ie, sequencing instruments and associated reagents) have been developed. Third-generation sequencing is another methodology currently under development that uses parallel sequencing similar to NGS. In contrast to NGS, third-generation sequencing uses single DNA molecules rather than amplified DNA as a template. PMID: 20858600 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: HIV 1 proviral DNA reverse transcriptase & protease gene mutations detected:Prid:Pt:Bld MC:Nom:Sequencing
Long Common Name: HIV 1 proviral DNA reverse transcriptase and protease gene mutations detected [Identifier] in Blood mononuclear cells by Sequencing
Short Name: HIV1 proviral DNA RT + PR Mut Det Seq
Display Name: HIV 1 proviral DNA reverse transcriptase and protease gene mutations detected Sequencing Nom (Bld MC)
Consumer Name Alpha Get Info: HIV 1 Proviral DNA Reverse Transcriptase and Protease gene variant analysis, Blood

Part Model Get Info

Component
HIV 1 proviral DNA reverse transcriptase & protease gene mutations detected
LP228628-6
- Analyte
  HIV 1 proviral DNA reverse transcriptase & protease gene mutations detected
  LP228628-6
  - Component Numerator
    HIV 1 proviral DNA reverse transcriptase & protease gene mutations detected
    LP228628-6
    - Component Numerator Core
      HIV 1 proviral DNA reverse transcriptase & protease gene
      LP207154-8
    - Component Numerator Core Suffix
      mutations detected
      LP32420-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
Prid
LP6850-4
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Bld MC
LP193850-7
- System Core
  Bld MC
  LP193850-7
- Super System
  NULL
Scale
Nom
LP7750-5
Method
Sequencing
LP150045-5

Example Answer List: LL2436-5

Source: Laboratory Corporation of America

Answer	Code	Score	Answer ID
V234L HIV mutation in the integrase (IN) coding region			LA24453-5
K13K/E HIV mutation in the reverse transcriptase (RT) coding region			LA19752-7
K20R HIV mutation in the reverse transcriptase (RT) coding region			LA19753-5
E28D HIV mutation in the reverse transcriptase (RT) coding region			LA19754-3
M41M/L HIV mutation in the reverse transcriptase (RT) coding region			LA19755-0
G359S HIV mutation in the reverse transcriptase (RT) coding region			LA25848-5
V35I HIV mutation in the reverse transcriptase (RT) coding region			LA25847-7
K14R HIV mutation in the integrase (IN) coding region			LA19756-8
V31I HIV mutation in the integrase (IN) coding region			LA19757-6
G193E HIV mutation in the integrase (IN) coding region			LA24451-9
D288N HIV mutation in the integrase (IN) coding region			LA24454-3
I62V HIV mutation in the protease (PR) coding region			LA19758-4
Q18K HIV mutation in the protease (PR) coding region			LA25851-9
E35D HIV mutation in the protease (PR) coding region			LA25852-7

Basic Attributes

Class: ABXBACT
Type: Laboratory
First Released: Version 2.56
Last Updated: Version 2.73 (MIN)
Order vs. Observation: Both
Common Test Rank Get Info: 18859

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	HIV 1 provirová DNA reverzní transkriptáza+proteáza genové mutace detekované:Přítomnost nebo identita:Časový bod:Buňky krevní mononukleární:Nominální:Sekvenace
el-GR	Greek (Greece)	Γονίδιο αντίστροφης μεταγραφάσης & πρωτεάσης προιικού DNA του ιού της ανθρώπινης ανοσοανεπάρκειας 1 ανιχνευθείσες μεταλλάξεις:Prid:Pt:Αίμα Μονοπύρηνα κύτταρα:Nom:Αλληλούχιση Synonyms: ABXBACT DNA HIV 1 Nom Prid Pt Αίμα Αίμα Μονοπύρηνα κύτταρα Αλληλούχιση ανιχνευθείσες μεταλλάξεις Γονίδιο Γονίδιο αντίστροφης μεταγραφάσης & πρωτεάσης προιικού DNA του ιού της ανθρώπινης ανοσοανεπάρκειας 1 Ιός ανθρώπινης ανοσοανεπάρκειας Ιός της ανθρώπινης ανοσοανεπάρκειας 1 προιϊκό Μεταλλάξεις Προιικό DNA ιού της ανθρώπινης ανοσοανεπάρκειας 1
es-ES	Spanish (Spain)	Gen de la transcriptasa inversa y proteasa del DNA proviral del HIV 1 Detección de mutaciones:Presencia o identidad:Punto temporal:Celulas Mononucleares sanguíneas:Nom:Secuenciación
es-MX	Spanish (Mexico)	Se detectaron mutaciones en el gen de la proteasa y la transcriptasa inversa del ADN proviral del VIH 1:Presencia o identidad:Punto temporal:Células mononucleares de sangre:Nominal:Secuenciación
fr-FR	French (France)	VIH-1 ADN proviral gènes réverse transcriptase et protéase mutations détectées:Identification:Ponctuel:Cellules mononucléées de sang périphérique:Résultat nominal:Séquençage
it-IT	Italian (Italy)	HIV 1 proviral,DNA gene trascrittasi inversa& proteasi, mutazioni identificate:Prid:Pt:Cellule mononucleate da sangue intero:Nom:Sequenziamento Synonyms: Presenza o Identità Punto nel tempo (episodio) Sangue Suscettibilità agli antibiotici
nl-NL	Dutch (Netherlands)	HIV 1 proviraal DNA reverse transcriptase & protease gen gedetecteerde mutaties:identificator:moment:mononucleaire cellen in bloed:nominaal:sequencing
pl-PL	Polish (Poland)	Prowirus HIV1 DNA odwrotna transkryptaza & proteaza gen wykryte mutacje:obecność lub identyfikacja:punkt w czasie:jednojądrzaste komórki krwi:skala nominalna:sekwencjonowanie Synonyms: Geny odwrotnej transkryptazy i proteazy prowirusa HIV1 DNA HIV 1 prowirusowy Kwas deoksyrybonukleinowy Ludzki wirus niedoboru odporności Ludzki wirus niedoboru odporności typu 1 Prowirusowe DNA HIV 1 wynik kategorialny
zh-CN	Chinese (China)	HIV 1 型前病毒 DNA 逆转录酶与蛋白酶基因已检出的突变:存在与否或特征标识:时间点:全血单个核细胞:名义型:序列测定 Synonyms: Ⅰ AIDS;AIDS 病毒;人类免疫缺陷病毒;人类免疫缺陷病毒（Human immunodeficiency virus，HIV）;爱滋病;艾滋病;艾滋病病毒;获得性免疫缺陷综合征;获得性免疫缺陷综合征（Acquired Immure Deficiency Syndrome，AIDS，艾滋病） HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型）前病毒;人类免疫缺陷病毒 1 型前病毒;人类免疫缺陷病毒 I 型前病毒 HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型）前病毒 DNA HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型）前病毒（前病毒型、潜伏性病毒） DNA（脱氧核糖核酸）逆转录酶（反转录酶、逆录酶、RT）与蛋白酶（Prot）基因 HIV1;HTLV 3;HTLV III;人类免疫缺陷病毒 1 型;人类免疫缺陷病毒 I 型;HIV 1 型（人类免疫缺陷病毒 1 型、人类免疫缺陷病毒 I 型、人免疫缺陷病毒 1 型、人免疫缺陷病毒 I 型、HIV I、HIV I 型、艾滋病病毒 I 型） I RT RTase 倒倒的倒转倒转的全血（血液、血）单个核细胞（单核细胞、MC）;全血标本（样品、样本、试样）单个核细胞分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答去氧核糖核酸;脱氧核糖核酸;脱氧核糖核酸（Deoxyribonucleic acid，DNA）反向反向的反常反常的反的反相反相的反转录酶存在;存在与否;特征标识;身份;身份标识已发现的突变序列分析;测序抗生素敏感性试验;药敏;药敏类;药敏试验;药敏试验类时刻;随机;随意;瞬间朊酶相反相反的突变突变类;基因突变蛋白质酵素血;血液逆逆的逆转录酶（Reverse transcriptase，RT）遗传基因;遗传因子;吉恩;生物基因颠倒颠倒的

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Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.