Version 2.80

80711-5 CD38+HLA-DR+ cells/CD3+CD4+ (T4 helper) cells in Blood

Part Descriptions

LP200623-9   Cells.CD38+HLA-DR+
Activated T-cells are characterized by coexpression of CD38 and HLA-DR and may be measured as fractions of CD4+ and CD8+ T-cell populations. In patients with HIV, activated T-cell levels are directly correlated to viral load and inversely correlated to CD4+ T-cell count. However, activated CD8+ T-cell levels may be more closely related to viral load, and successful treatment with anti-retroviral therapy with resulting decrease in viral load has been associated with a concomitant decrease in activated CD8+ T-cells. Likewise, increases in CD4+ T-cell counts have been associated with a decrease in the level of activated CD4+ T-cells. In addition, co-infection in patients with HIV is also associated with CD4+ T-cell activation but not that of the CD8+ T-cell population. PMID: 15688282 Source: Regenstrief LOINC

LP99724-4   Cells.CD3+CD4+
HIV infection decreases the number of CD3+ CD4+ lymphocytes (also called CD4 T cells or T4 helper cells) while increasing (momentarily) the numbers of CD3+CD8+ lymphocytes (called CD8 T lymphocytes or cytotoxic T cells). Thus the ratio of CD4/CD8 lymphocytes is decreased. These counts are used for prognostic purposes and to guide in the retroviral therapy. CDC has emphasized since 1997 that the number of CD3+ lymphocytes is necessary in addition to the number of CD4+ cells to reliably identify the T4 helper cells and the number of CD8+ cells. Laboratory reports that include only CD4 or only CD8 in their nomenclature are most likely really measuring CD3+CD4+ cells and CD3+CD8+ cells, respectively. Source: Regenstrief Help

LP14443-3   CD4
Found on helper T-cells; weakly expressed on monocytes.
Associated with some mature T-cell neoplasms, including most cases of T-cell CLL/prolymphocytic leukemia, peripheral
T-cell lymphoma, adult T-cell leukemia/lymphoma and Sézary syndrome/mycosis fungoides Source: Regenstrief LOINC

Fully-Specified Name

Component
Cells.CD38+HLA-DR+/Cells.CD3+CD4+
Property
NFr
Time
Pt
System
Bld
Scale
Qn
Method

Basic Attributes

Class
CELLMARK
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.79 (NAM)
Change Reason
Release 2.79: COMPONENT: Triggered by Coll w SCT: This is a specific fraction case where the denominator is percentage or /100. Because the logic is that the percentage piece is captured by Property: NFr (Numeric Fraction), and by Unit: %, therefore, it is redundant to include "100" in the component;
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
80716-4 T-cell activated (CD38+HLA-DR+) subsets panel - Blood

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Κύτταρα.CD38+Ανθρώπινα λευκοκυτταρικά αντιγόνα-DR+/Κύτταρα.CD3+CD4+:NFr:Pt:Αίμα:Qn:
Synonyms: CD3 CD38 CD4 NFr Ανθρώπινα λευκοκυτταρικά αντιγόνα Ανθρώπινα λευκοκυτταρικά αντιγόνα-DR Κύτταρα Κύτταρα.CD3 Κύτταρα.CD3+CD4+ Κύτταρα.CD38 Κύτταρα.CD38+Ανθρώπινα λευκοκυτταρικά αντιγόνα-DR+ Κύτταρα.CD3-CD4+
es-ES Spanish (Spain) Células CD38+HLA-DR+/Células CD3+CD4+:Fracción numérica:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Cells.CD38 + HLA-DR + / 100 Cells.CD3 + CD4 +:Fracción numérica:Punto temporal:Sangre:Cuantitativo:
fr-FR French (France) CD38+HLA-DR+/100 cellules CD3+CD4+:Fraction de nombres:Ponctuel:Sang:Numérique:
it-IT Italian (Italy) Cellule.CD38+HLA-DR+/Cellule.CD3+CD4+:NFr:Pt:Sangue:Qn:
Synonyms: Cellule CD3 Cellule CD3+CD4+ Cellule CD3+CD4+ (T4 aiutanti) Cellule CD38 Cellule CD38+HLA-DR+ Cellule CD3-CD4+ Frazione numerica Modelli di superficie cellulare Punto nel tempo (episodio) Sangue
nl-NL Dutch (Netherlands) cellen.CD38+HLA-DR+/cellen.CD3+CD4+:getalsfractie:moment:bloed:kwantitatief:
zh-CN Chinese (China) 细胞.CD38+HLA-DR+/细胞.CD3+CD4+:计数型分数:时间点:全血:定量型:
Synonyms: ADP-核糖基环化酶;Leu17;Leu-17;T10;二磷酸腺苷-核糖基环化酶;二磷酸腺苷-核糖基环化酶（ADP-ribosyl cyclase）;发现于早期 T- 和 B-细胞、激活型 T- 和 B-细胞以及浆细胞之上。与浆细胞型肿瘤、外周T-细胞淋巴瘤以及一些 B-细胞淋巴瘤相关。;环二磷酸腺苷-核糖水解酶;环二磷酸腺苷-核糖水解酶（Cyclic ADP-ribose hydrolase） CD3+CD4+细胞 CD38细胞 CD3-CD4+细胞 CD3细胞 HLA 抗原;人类白细胞抗原;human leukocyte antigen I3 L3T4 Leu3 Leu-3 Leu4;Leu-4;T3 T4 T-4 W3/25 人白细胞抗原 人类白细胞抗原 人类白细胞抗原（Human Leukocyte Antigen，HLA） 发现于辅助 T-细胞；微弱表达于单核细胞。与相关。一些成熟 T-细胞肿瘤，包括大多数情况下的 T-细胞慢性淋巴细胞白血病/前淋巴细胞白血病、外周 T-细胞淋巴瘤、成人 T-细胞白血病/淋巴瘤以及 Sézary 综合征（T 细胞红皮病）/蕈样肉芽肿（mycosis fungoides）。 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 数量型分数;数量或计数型分数;数量型分数或计数型分数 时刻;随机;随意;瞬间 白细胞抗原 细胞含量;细胞性;细胞性质;细胞构成;细胞类 细胞标志物 血;血液 诱导 T 细胞 诱导性 T 细胞 辅助 T 细胞 辅助诱导 T 细胞 辅助诱导物 T 细胞

Example Units

Unit Source
% Example UCUM Units

80712-3 CD38+HLA-DR+ cells/CD3+CD8+ (T8 suppressor cells) cells in Blood

Part Descriptions

LP100021-7   Cells.CD3+CD8+
HIV infection decreases the number of CD3+ CD4+ lymphocytes (also called CD4 T cells or T4 helper cells) while increasing (momentarily) the numbers of CD3+CD8+ lymphocytes (called CD8 T lymphocytes or cytotoxic T cells). Thus the ratio of CD4/CD8 lymphocytes is decreased. These counts are used for prognostic purposes and to guide in the retroviral therapy. CDC has emphasized since 1997 that the number of CD3+ lymphocytes is necessary in addition to the number of CD4+ cells to reliably identify the T4 helper cells and the number of CD8+ cells. Laboratory reports that include only CD4 or only CD8 in their nomenclature are most likely really measuring CD3+CD4+ cells and CD3+CD8+ cells, respectively. Source: Regenstrief Help

LP200623-9   Cells.CD38+HLA-DR+
Activated T-cells are characterized by coexpression of CD38 and HLA-DR and may be measured as fractions of CD4+ and CD8+ T-cell populations. In patients with HIV, activated T-cell levels are directly correlated to viral load and inversely correlated to CD4+ T-cell count. However, activated CD8+ T-cell levels may be more closely related to viral load, and successful treatment with anti-retroviral therapy with resulting decrease in viral load has been associated with a concomitant decrease in activated CD8+ T-cells. Likewise, increases in CD4+ T-cell counts have been associated with a decrease in the level of activated CD4+ T-cells. In addition, co-infection in patients with HIV is also associated with CD4+ T-cell activation but not that of the CD8+ T-cell population. PMID: 15688282 Source: Regenstrief LOINC

LP17729-2   CD8
Found on T-suppressor/cytotoxic cells and some Natural Killer cells; Associated with some mature T-cell neoplasms; Large granular lymphocytosis Source: Regenstrief LOINC

Fully-Specified Name

Component
Cells.CD38+HLA-DR+/Cells.CD3+CD8+
Property
NFr
Time
Pt
System
Bld
Scale
Qn
Method

Basic Attributes

Class
CELLMARK
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.79 (NAM)
Change Reason
Release 2.79: COMPONENT: Triggered by Coll w SCT: This is a specific fraction case where the denominator is percentage or /100. Because the logic is that the percentage piece is captured by Property: NFr (Numeric Fraction), and by Unit: %, therefore, it is redundant to include "100" in the component;
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
80716-4 T-cell activated (CD38+HLA-DR+) subsets panel - Blood

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Κύτταρα.CD38+Ανθρώπινα λευκοκυτταρικά αντιγόνα-DR+/Κύτταρα.CD3+CD8+:NFr:Pt:Αίμα:Qn:
Synonyms: CD3 CD38 CD8 NFr Ανθρώπινα λευκοκυτταρικά αντιγόνα Ανθρώπινα λευκοκυτταρικά αντιγόνα-DR Κύτταρα Κύτταρα.CD3 Κύτταρα.CD3+CD8+ Κύτταρα.CD38 Κύτταρα.CD38+Ανθρώπινα λευκοκυτταρικά αντιγόνα-DR+
es-ES Spanish (Spain) Células CD38+HLA-DR+/Células CD3+CD8+:Fracción numérica:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Cells.CD38 + HLA-DR + / 100 Cells.CD3 + CD8 +:Fracción numérica:Punto temporal:Sangre:Cuantitativo:
fr-FR French (France) CD38+HLA-DR+/100 cellules CD3+CD8+:Fraction de nombres:Ponctuel:Sang:Numérique:
it-IT Italian (Italy) Cellule.CD38+HLA-DR+/Cellule.CD3+CD8+:NFr:Pt:Sangue:Qn:
Synonyms: Cellule CD3 Cellule CD3+CD8+ Cellule CD3+CD8+ (cellule soppressore T8) Cellule CD38 Cellule CD38+HLA-DR+ Frazione numerica Modelli di superficie cellulare Punto nel tempo (episodio) Sangue
nl-NL Dutch (Netherlands) cellen.CD38+HLA-DR+/cellen.CD3+CD8+:getalsfractie:moment:bloed:kwantitatief:
zh-CN Chinese (China) 细胞.CD38+HLA-DR+/细胞.CD3+CD8+:计数型分数:时间点:全血:定量型:
Synonyms: ADP-核糖基环化酶;Leu17;Leu-17;T10;二磷酸腺苷-核糖基环化酶;二磷酸腺苷-核糖基环化酶（ADP-ribosyl cyclase）;发现于早期 T- 和 B-细胞、激活型 T- 和 B-细胞以及浆细胞之上。与浆细胞型肿瘤、外周T-细胞淋巴瘤以及一些 B-细胞淋巴瘤相关。;环二磷酸腺苷-核糖水解酶;环二磷酸腺苷-核糖水解酶（Cyclic ADP-ribose hydrolase） CD3+CD8+细胞 CD38细胞 CD3细胞 HLA 抗原;人类白细胞抗原;human leukocyte antigen I3 Leu2 Leu-2 Leu4;Leu-4;T3 T8 T-8 Tsuppressor 人白细胞抗原 人类白细胞抗原 人类白细胞抗原（Human Leukocyte Antigen，HLA） 发现于 抑制性 T-细胞/细胞毒性 T-细胞、一些 NK 细胞之上。与一些成熟 T-细胞肿瘤和大颗粒淋巴细胞增多症相关 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 抑制性 T 细胞 抑制性 T-细胞 数量型分数;数量或计数型分数;数量型分数或计数型分数 时刻;随机;随意;瞬间 白细胞抗原 细胞含量;细胞性;细胞性质;细胞构成;细胞类 细胞标志物 血;血液

Example Units

Unit Source
% Example UCUM Units