Version 2.78

Term Description

The patient's CYP3A5 gene allelic genotype (e.g. *1/*6) based on analysis of multiple variants within the CYP3A5 gene, such as g.27289C>A (rs28365083, *2) , 6986A>G (rs776746, *3), 14690G>A (rs10264272. *6) and 27131-27132insT (rs76293380. *7).
Source: Regenstrief LOINC

Part Description

LP417571-9   CYP3A5 gene allele
Cytochrome P450-3A5 (CYP3A5; [HGNC Gene ID: 2638]), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism many drugs in current clinical use. Genetic variations in CYP3A5 can affect the response (i.e., efficacy or toxicity) to drugs metabolized by CYP3A5 and selection of alternative dosing or agents may be necessary in individuals with specific CYP3A5 genetic variations. PMID: 25801146 See https://www.pharmgkb.org/gene/PA131 for more information and dosing guidelines for drugs impacted by CYP3A5 genetic variation. Source: Clinical Pharmacogenetics Implementation Consortium

Fully-Specified Name

Component
CYP3A5 gene allele
Property
Geno
Time
Pt
System
Bld/Tiss
Scale
Nom
Method
Molgen

Additional Names

Short Name
CYP3A5 allele Geno Bld/T
Display Name
CYP3A5 gene allele genotype Molgen (Bld/Tiss)
Consumer Name Alpha Get Info
CYP3A5 gene allele genotype, Blood or tissue specimen

Example Answer List: LL2543-8

Source: Regenstrief LOINC
Answer Code Score Answer ID
CYP3A5*1/*1 LA25991-3
CYP3A5*1/*2 LA20131-1
CYP3A5*1/*3 LA20127-9
CYP3A5*1/*6 LA25995-4
CYP3A5*3/*3 LA20132-9
CYP3A5*3/*5 LA20133-7
CYP3A5*3/*6 LA25998-8

Basic Attributes

Class
MOLPATH.PHARMG
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.73
Change Reason
Release 2.68: CLASS: Updated to MOLPATH.PHARMG, the more representative LOINC Class for this concept.; COMPONENT: Updated Component to align with the LOINC term naming model for concepts used to report allelic genotypes (e.g. CYP3A5*1/*6), which was the original intent for this term.; Release 2.67: CLASS: Updated to MOLPATH.PHARMG, the more representative LOINC Class for this concept.
Order vs. Observation
Both
Common Test Rank Get Info
9798

Member of these Panels

LOINC Long Common Name
81642-1 CYP3A4 and CYP3A5 gene targeted mutation analysis panel - Blood or Tissue by Molecular genetics method

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Alelo del gen CYP3A5:Genotipo:Punto temporal:Sangre o tejido:Nom:Genética molecular
es-MX Spanish (Mexico) Alelo del gen CYP3A5:Genotipo:Punto temporal:Sangre o tejido:Nominal:Genética molecular
fr-FR French (France) CYP3A5 gène allèle:Génotype:Ponctuel:Sang/Tissu:Résultat nominal:Biologie moléculaire
it-IT Italian (Italy) CYP3A5, gene allele:Geno:Pt:Sangue/Tess:Nom:Molgen
Synonyms: Farmacogenomica Gene CYP3A5 Genetica molecolare Genotipo Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL Dutch (Netherlands) CYP3A5-allel:genotype:moment:bloed of weefsel:nominaal:moleculair genetisch onderzoek
Synonyms: molgen
zh-CN Chinese (China) CYP3A5 基因等位基因:基因型:时间点:全血/组织:名义型:分子遗传学类实验室方法
Synonyms: EC 1.14.14.1;细胞色素 P450 家族 3 亚家族 A 成员 5;细胞色素 P450, 亚家族 IIIA (硝苯吡啶氧化酶), 多肽 5;细胞色素 P450, 家族 3, 亚家族 A, 多肽 5;细胞色素 P450 HLp2;细胞色素 P450-PCN3;Cytochrome P450 Family 3 Subfamily A Member 5;Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 5 全血或组织;血液/组织;血液或组织 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 血;血液 遗传基因;遗传因子;吉恩;生物基因

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=81140-6