Version 2.78

Part Description

LP212218-4   Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, also known as phosphate and tensin homolog or PTEN protein, is encoded by the PTEN gene on chromosome10q23.31. PTEN protein has multiple functions, including protein phosphatase and lipid phosphatase activity. The lipid phosphatase function is critical for its role as a tumor suppressor and modulating cell cycle progression and cell survival. It also plays a role in correct neuron positioning, dendritic development and synapse formation, and may be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. Mutations in the PTEN gene are associated with multiple disorders, including PTEN hamartoma tumor syndromes, which include Cowden syndrome and Lhermitte-Duclos disease, squamous cell carcinoma of the head and neck, endometrial carcinoma, prostate cancer, and VACTERL with hydrocephalus. [UniProt: P60484] Loss of the PTEN gene can be determined by various techniques, including FISH, and loss of the PTEN protein can be detected by immunohistochemistry techniques. Source: Regenstrief LOINC, UniProt: P60484

Fully-Specified Name

Component
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Property
PrThr
Time
Pt
System
Cancer specimen
Scale
Ord
Method
Immune stain

Additional Names

Short Name
PTEN protein Ca spec Ql ImStn
Display Name
Phosphatase and tensin homolog (PTEN) protein Immune stain Ql (Cancer specimen)
Consumer Name Alpha Get Info
Phosphatase and Tensin Homolog (PTEN) Protein, Cancer specimen

Example Answer List: LL2038-9

Source: Quest Diagnostics Inc.
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6
IndeterminateCopyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value) LA11884-6

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.61
Change Reason
Updated System from "Tiss" to "Cancer.XXX" because PTEN protein immune staining is performed on cancer specimens.; Updated System from "Cancer.XXX" to clarify that the test is performed on a cancer specimen.
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
85905-8 Cancer pathology panel - Colorectal cancer specimen by CAP cancer protocols

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Fosfatidilinositol 3,4,5-trifosfato 3-fosfatasa y especificidad dual de proteinfosfatasa PTEN:PrThr:Punto temporal:Muestra de cancer:Ord:Tinción de inmunohistoquímica
es-MX Spanish (Mexico) Fosfatidilinositol 3,4,5-trifosfato 3-fosfatasa y proteína fosfatasa de especificidad dual PTEN:Presencia o umbral:Punto temporal:Espécimen de cáncer:Ordinal:Mancha inmune
it-IT Italian (Italy) Fosfatidilinositolo 3,4,5- trifosfato 3-fosfato e proteina PTEN fosfatasi a doppia specificità:PrThr:Pt:Campione tumore:Ord:Colorazione immunologica
Synonyms: Campione di tumore Neoplasia maligna Patologia Presenza o Soglia Punto nel tempo (episodio)
zh-CN Chinese (China) 磷脂酰肌醇 3,4,5-三磷酸 3-磷酸酯酶与双特异性蛋白磷酸酯酶 PTEN:存在情况或阈值:时间点:癌标本:序数型:免疫染色法
Synonyms: Ⅲ III PI;磷脂酰环己六醇;磷脂酰肌;磷脂酰肌醇（Phosphatidylinositol，PI） PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 三 供检查用的材料;待检物;待试验物;样品;样本;试料;试样 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫染色;免疫组化;免疫组化染色;免疫组化染色法;免疫组化法;免疫组织化学染色;免疫组织化学染色法;细胞免疫染色;细胞免疫染色法 叁 受检物 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 染法 染色方法 染色法 样品 样本 癌 癌（癌症、癌变）标本（样本、样品、试样） 着色 着色方法 着色法 磷脂酰肌醇（PI、磷脂酰环己六醇、磷脂酰肌、磷脂酰肌醇） 3,4,5-三磷酸 3-磷酸酯酶（磷酸酶）与双特异性（双重特异性）蛋白磷酸酯酶（磷酸酶） PTEN 磷酸单酯酶 磷酸酶 试样

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=81706-4