81706-4

Phosphatase and tensin homolog (PTEN) protein Ag [Presence] in Cancer specimen by Immune stain

Active

Part Description

LP212218-4 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, also known as phosphate and tensin homolog or PTEN protein, is encoded by the PTEN gene on chromosome10q23.31. PTEN protein has multiple functions, including protein phosphatase and lipid phosphatase activity. The lipid phosphatase function is critical for its role as a tumor suppressor and modulating cell cycle progression and cell survival. It also plays a role in correct neuron positioning, dendritic development and synapse formation, and may be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. Mutations in the PTEN gene are associated with multiple disorders, including PTEN hamartoma tumor syndromes, which include Cowden syndrome and Lhermitte-Duclos disease, squamous cell carcinoma of the head and neck, endometrial carcinoma, prostate cancer, and VACTERL with hydrocephalus. [UniProt: P60484] Loss of the PTEN gene can be determined by various techniques, including FISH, and loss of the PTEN protein can be detected by immunohistochemistry techniques. Source: Regenstrief LOINC, UniProt: P60484

LOINC Names Get Info

Fully-Specified Name: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Ag:PrThr:Pt:Cancer specimen:Ord:Immune stain
Long Common Name: Phosphatase and tensin homolog (PTEN) protein Ag [Presence] in Cancer specimen by Immune stain
Short Name: PTEN protein Ag Ca spec Ql ImStn
Display Name: Phosphatase and tensin homolog (PTEN) protein Ag Immune stain Ql (Cancer specimen)
Consumer Name Alpha Get Info: Phosphatase and Tensin Homolog (PTEN) Protein antigen, Cancer specimen

Part Model Get Info

Component
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Ag
LP450033-8
- Analyte
  Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Ag
  LP450033-8
  - Component Numerator
    Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Ag
    LP450033-8
    - Component Numerator Core
      Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
      LP212218-4
    - Component Numerator Core Suffix
      Ag
      LP20666-1
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Cancer specimen
LP247830-5
- System Core
  Cancer specimen
  LP247830-5
- Super System
  NULL
Scale
Ord
LP7751-3
Method
Immune stain
LP6333-1

Example Answer List: LL2038-9

Source: Quest Diagnostics Inc.

Answer	Code	Score	Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6
IndeterminateCopyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value)			LA11884-6

Basic Attributes

Class: PATH
Type: Laboratory
First Released: Version 2.56
Last Updated: Version 2.82 (NAM)
Change Reason: Updated System from "Tiss" to "Cancer.XXX" because PTEN protein immune staining is performed on cancer specimens.; Updated System from "Cancer.XXX" to clarify that the test is performed on a cancer specimen.
Order vs. Observation: Observation

Member of these Panels

LOINC	Long Common Name
85905-8	Cancer pathology panel - Colorectal cancer specimen by CAP cancer protocols

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Protein Homolog fosfatázy a tensinu (PTEN):Přítomnost nebo práh:Časový bod:Vzorek karcinomu:Ordinální:Imunobarvení
el-GR	Greek (Greece)	3-φωσφατάση της 3,4,5,-τριφωσφορικής φωσφατιδυλινοσιτόλης και διπλής ειδικότητας πρωτεϊνική φωσφατάση PTEN Αντιγόνο:PrThr:Pt:Δείγμα καρκίνου:Ord:Ανοσολογική χρώση Synonyms: 3-φωσφατάση της 3,4,5,-τριφωσφορικής φωσφατιδυλινοσιτόλης και διπλής ειδικότητας πρωτεϊνική φωσφατάση PTEN Ord PATH PrThr Pt Ανοσολογική χρώση Αντιγόνο Δείγμα Δείγμα καρκίνου Καρκίνος Πρωτεΐνη Φωσφατιδυλινοσιτόλη
es-ES	Spanish (Spain)	Fosfatidilinositol 3,4,5-trifosfato 3-fosfatasa y especificidad dual de proteinfosfatasa PTEN Antígeno:PrThr:Punto temporal:Muestra de cancer:Ord:Tinción de inmunohistoquímica
es-MX	Spanish (Mexico)	Fosfatidilinositol 3,4,5-trifosfato 3-fosfatasa y proteína fosfatasa de especificidad dual PTEN:Presencia o umbral:Punto temporal:Espécimen de cáncer:Ordinal:Mancha inmune
it-IT	Italian (Italy)	Fosfatidilinositolo 3,4,5- trifosfato 3-fosfato e proteina PTEN fosfatasi a doppia specificità, Ag:PrThr:Pt:Campione tumore:Ord:Colorazione immunologica Synonyms: Campione di tumore Neoplasia maligna Patologia Presenza o Soglia Punto nel tempo (episodio)
pl-PL	Polish (Poland)	Fosfatydyloinozytol 3,4,5-trisfosforan 3-fosfataza i białkowa fosfataza o podwójnej specyficzności PTEN Ag:granica wykrywalności:punkt w czasie:próbka nowotworu:uporządkowany:barwienie immunohistochemiczne Synonyms: nowotwór
zh-CN	Chinese (China)	磷脂酰肌醇 3,4,5-三磷酸 3-磷酸酯酶与双特异性蛋白磷酸酯酶 PTEN 抗原:存在情况或阈值:时间点:癌标本:序数型:免疫染色法 Synonyms: Ⅲ Ag III PI;磷脂酰环己六醇;磷脂酰肌;磷脂酰肌醇（Phosphatidylinositol，PI） PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质三供检查用的材料;待检物;待试验物;样品;样本;试料;试样依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型免疫染色;免疫组化;免疫组化染色;免疫组化染色法;免疫组化法;免疫组织化学染色;免疫组织化学染色法;细胞免疫染色;细胞免疫染色法叁受检物存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）时刻;随机;随意;瞬间染法染色方法染色法样品样本癌癌（癌症、癌变）标本（样本、样品、试样）着色着色方法着色法磷脂酰肌醇（PI、磷脂酰环己六醇、磷脂酰肌、磷脂酰肌醇） 3,4,5-三磷酸 3-磷酸酯酶（磷酸酶）与双特异性（双重特异性）蛋白磷酸酯酶（磷酸酶） PTEN 磷酸单酯酶磷酸酶试样

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=81706-4

Third Party Copyright

This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO) under license. All rights reserved. SNOMED CT® was originally created by The College of American Pathologists. "SNOMED" and "SNOMED CT" are registered trademarks of the IHTSDO.

This material includes content from the US Edition to SNOMED CT, which is developed and maintained by the U.S. National Library of Medicine and is available to authorized UMLS Metathesaurus Licensees from the UTS Downloads site at https://uts.nlm.nih.gov.

Use of SNOMED CT content is subject to the terms and conditions set forth in the SNOMED CT Affiliate License Agreement. It is the responsibility of those implementing this product to ensure they are appropriately licensed and for more information on the license, including how to register as an Affiliate Licensee, please refer to https://www.snomed.org/get-snomed or [email protected]<mailto:[email protected]>. This may incur a fee in SNOMED International non-Member countries.

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.