Phosphatase and tensin homolog (PTEN) protein [Presence] in Cancer specimen by Immune stain
LP212218-4 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, also known as phosphate and tensin homolog or PTEN protein, is encoded by the PTEN gene on chromosome10q23.31. PTEN protein has multiple functions, including protein phosphatase and lipid phosphatase activity. The lipid phosphatase function is critical for its role as a tumor suppressor and modulating cell cycle progression and cell survival. It also plays a role in correct neuron positioning, dendritic development and synapse formation, and may be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. Mutations in the PTEN gene are associated with multiple disorders, including PTEN hamartoma tumor syndromes, which include Cowden syndrome and Lhermitte-Duclos disease, squamous cell carcinoma of the head and neck, endometrial carcinoma, prostate cancer, and VACTERL with hydrocephalus. [UniProt: P60484] Loss of the PTEN gene can be determined by various techniques, including FISH, and loss of the PTEN protein can be detected by immunohistochemistry techniques. Source: Regenstrief LOINC, UniProt: P60484
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Cancer specimen
- Immune stain
- Short Name
- PTEN protein Ca spec Ql ImStn
- Display Name
- Phosphatase and tensin homolog (PTEN) protein Immune stain Ql (Cancer specimen)
- Consumer Name Alpha
- Phosphatase and Tensin Homolog (PTEN) Protein, Cancer specimen
Example Answer List: LL2038-9Source: Quest Diagnostics Inc.
|PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)||LA6576-8|
|NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)||LA6577-6|
|IndeterminateCopyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value)||LA11884-6|
- First Released
- Version 2.56
- Last Updated
- Version 2.61
- Change Reason
- Updated System from "Tiss" to "Cancer.XXX" because PTEN protein immune staining is performed on cancer specimens.; Updated System from "Cancer.XXX" to clarify that the test is performed on a cancer specimen.
- Order vs. Observation
Member of these Panels
|LOINC||Long Common Name|
|85905-8||Cancer pathology panel - Colorectal cancer specimen by CAP cancer protocols|
|zh-CN||Chinese (China)||磷脂酰肌醇 3,4,5-三磷酸 3-磷酸酯酶与双特异性蛋白磷酸酯酶 PTEN:
|es-ES||Spanish (Spain)||Fosfatidilinositol 3,4,5-trifosfato 3-fosfatasa y especificidad dual de proteinfosfatasa PTEN:
|it-IT||Italian (Italy)||Fosfatidilinositolo 3,4,5- trifosfato 3-fosfato e proteina PTEN fosfatasi a doppia specificità:
|es-MX||Spanish (Mexico)||Fosfatidilinositol 3,4,5-trifosfato 3-fosfatasa y proteína fosfatasa de especificidad dual PTEN:
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