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Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.

Part Description

LP157221-5   RNA polymerase III RP11
POL3RK gene encodes a small essential subunit (known as RP11) of RNA polymerase III, which synthesizes small RNAs such as 5S rRNA and tRNAs. The POL3RK protein plays a key role in sensing and reducing infection by intracellular bacteria and DNA viruses. It acts as a sensor involved in innate immune response. The presence of antibodies directed against POL3RK (anti-Polymerase, DNA-directed) are thought to be associated with systemic sclerosis (SSc), a connective tissue disease that affects the skin and internal organs. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
RNA polymerase III RP11 Ab:PrThr:Pt:Ser:Ord:Line blot
Long Common Name
RNA polymerase III RP11 Ab [Presence] in Serum by Line blot
Short Name
RNAp III RP11 Ab Ser Ql Line blot
Display Name
RNA polymerase III RP11 Ab Line blot Ql (S)
Consumer Name Alpha Get Info
RNA Polymerase III RP11 antibody, Blood

Part Model Get Info

  • Component
    RNA polymerase III RP11 Ab
    LP157211-6
    • Analyte
      RNA polymerase III RP11 Ab
      LP157211-6
      • Component Numerator
        RNA polymerase III RP11 Ab
        LP157211-6
        • Component Numerator Core
          RNA polymerase III RP11
          LP157221-5
        • Component Numerator Core Suffix
          Ab
          LP20667-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Ser
    LP7567-3
    • System Core
      Ser
      LP7567-3
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Line blot
    LP266806-1

Example Answer List: LL360-9

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)LA6577-6

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.56
Last Updated
Version 2.64 (MAJ)
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)RNA polymeráza III RP11 Ab:Přítomnost nebo práh:Časový bod:Sérum:Ordinální:Line blot
de-DEGerman (Germany)RNA-Polymerase III RP11 Ak:Nachweis oder Schwellenwert:Zeitpunkt:Serum:Ordinal:Line-Blot
el-GRGreek (Greece)RNA πολυμεράση III RP11 Αντίσωμα:PrThr:Pt:Ορός:Ord:Γραμμή κηλίδωσης
Synonyms: Ord PrThr Pt RNA RNA πολυμεράση III RNA πολυμεράση III RP11 SERO Αντίσωμα Γραμμή κηλίδωσης Ορός
es-ESSpanish (Spain)ARN polimerasa III RP11 Anticuerpos:PrThr:Punto temporal:Suero:Ord:Line blot
es-MXSpanish (Mexico)ARN polimerasa III RP11 Ab:Presencia o umbral:Punto temporal:Suero:Ordinal:Mancha de línea
fr-FRFrench (France)ARN polymérase III RP11 Ac:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
it-ITItalian (Italy)RNA polimerasi III RP11 Ab:PrThr:Pt:Siero:Ord:Line blot
Synonyms: anticorpo Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NLDutch (Netherlands)RNA-polymerase III RP11 As:aanwezigheid:moment:serum:ordinaal:lijnblot
Synonyms: antistof; antilichaam
zh-CNChinese (China)RNA 聚合酶 III RP11 抗体:存在情况或阈值:时间点:血清:序数型:线点印迹法
Synonyms: Ab;自身抗体 RNA 多聚酶 III RP11;核糖核酸多聚酶 III RP11;核糖核酸聚合酶 III RP11;RNAp III RP11 RNA 多聚酶 III;核糖核酸多聚酶 III;核糖核酸聚合酶 III;RNAp III 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 核糖核酸;Ribonucleic acid 线点杂交技术;线点杂交法;线条状印迹法 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=81737-9