81793-2

Tetrahydrodeoxycortisol/Creatinine [Molar ratio] in 24 hour Urine

Active

Part Descriptions

LP15884-7 Tetrahydrodeoxycortisol
Tetrahydrodeoxycortisol (THS) is a mineralocorticoid the main urinary metabolite of 11-deoxycortisol. THS excretion is significantly associated with tetrahydroaldosterone excretion, total androgen excretion, and cortisol metabolites. Aldosterone synthesis is highly heritable and is affected by genotype at CYP11B1. Variation in the region of chromosome 8 including the genes steroid 11-beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) influences mineralocorticoid and glucocorticoid metabolism; differences in 11-hydroxylation efficiency can have downstream effects on mineralocorticoid synthesis. Such effects may be of relevance to the development of low-renin essential hypertension. Genotype differences in CYP11B1 explains approximately 5% of the variance in urinary THS excretion in the population. Excretion of THS is heritable (19.4%) and the T-allele of the -344 C/T polymorphism of CYP11B2 is more strongly associated with higher THS levels than the C-allele. PMID: 16984984, PMID: 15522937, PMID: 15272911. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Tetrahydrodeoxycortisol

LP32035-5 Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Creatinine

LOINC Names Get Info

Fully-Specified Name: Tetrahydrodeoxycortisol/Creatinine:SRto:24H:Urine:Qn:
Long Common Name: Tetrahydrodeoxycortisol/Creatinine [Molar ratio] in 24 hour Urine
Short Name: TH-DC/Creat 24h Ur-sRto
Display Name: Tetrahydrodeoxycortisol/Creatinine (24H U) [Molar ratio]
Consumer Name Alpha Get Info: Tetrahydrodeoxycortisol/Creatinine, Urine

Part Model Get Info

Component
Tetrahydrodeoxycortisol/Creatinine
LP287220-0
- Analyte
  Tetrahydrodeoxycortisol/Creatinine
  LP287220-0
  - Component Numerator
    Tetrahydrodeoxycortisol
    LP15884-7
    - Component Numerator Core
      Tetrahydrodeoxycortisol
      LP15884-7
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    Creatinine
    LP32035-5
    - Component Denominator Core
      Creatinine
      LP32035-5
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
SRto
LP6868-6
Time
24H
LP6924-7
- Time Core
  24H
  LP6924-7
- Time Modifier
  NULL
System
Urine
LP7681-2
- System Core
  Urine
  LP7681-2
- Super System
  NULL
Scale
Qn
LP7753-9
Method
NULL

Basic Attributes

Class: CHEM
Type: Laboratory
First Released: Version 2.56
Last Updated: Version 2.56 (ADD)
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
73885-6	Steroid fractions panel - 24 hour Urine

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Tetrahydrodeoxykortizol/kreatinin:Látkový poměr:24 hodin:Moč:Kvantitativní:
el-GR	Greek (Greece)	Τετραϋδροδεοξυκορτιζόλη/Κρεατινίνη:SRto:24H:Ούρα:Qn: Synonyms: 24H CHEM Qn SRto Κρεατινίνη Ούρα Τετραϋδροδεοξυκορτιζόλη
es-ES	Spanish (Spain)	Tetrahidrodesoxicortisol/Creatinina:Relacion de Sustancia:24 horas:Orina:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Tetrahidrodesoxicortisol / creatinina:Proporción de sustancia:24H:Orina:Cuantitativo:
fr-FR	French (France)	Tétrahydro-11-déoxycortisol/créatinine:Moles ratio:24H:Urine:Numérique:
it-IT	Italian (Italy)	Tetraidrodeossicortisolo/Creatinina:Srto:24h:Urine:Qn: Synonyms: 24 Ore Chimica Rapporto di sostanza
nl-NL	Dutch (Netherlands)	tetrahydrodeoxycortisol/creatinine:molaire verhouding:24 uur:urine:kwantitatief: Synonyms: 24U kreatinine
pl-PL	Polish (Poland)	Tetrahydrodeoksykortyzol/kreatynina:współczynnik molowy:24h:mocz:ilościowy: Synonyms: 24 godziny
ru-RU	Russian (Russian Federation)	Тетрагидродеоксикортизол/Креатинин:МольОтн:24 часа:Моча:Колич: Synonyms: Количественный Мольная доля;Молярная доля;Отношение концентраций Тетрагидродезоксикортизол
tr-TR	Turkish (Turkey)	Tetrahidrodeoksikortizol/Kreatinin:SOrn:24Sa:İdrar:Kant: Synonyms: SubsOranı
zh-CN	Chinese (China)	四氢脱氧皮质醇/肌酐:物质的量比率:24小时:尿液:定量型: Synonyms: 1天;1日;24.0小时;一天;一日;二十四个小时;二十四小时 CR;Creat;肌氨酸酐;肌酸内酰胺;肌酸酐 TH-DC;四氢-11-脱氧皮质醇;四氢脱氧皮质甾醇;四氢脱氧皮醇 UCr 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类可用数量表示的;定量性;数值型;数量型;连续数值型标尺尿;小便;下泉尿液肌酐尿液肌酸酐尿肌酸酐物质的量比值;物质的量比;摩尔比;摩尔比率;摩尔比值肌酸内酰胺

Example Units

Unit	Source
umol/mol{creat}	Example UCUM Units

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=81793-2

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.