81793-2

Tetrahydrodeoxycortisol/Creatinine [Molar ratio] in 24 hour Urine

Active

Part Descriptions

LP15884-7   Tetrahydrodeoxycortisol
Tetrahydrodeoxycortisol (THS) is a mineralocorticoid the main urinary metabolite of 11-deoxycortisol. THS excretion is significantly associated with tetrahydroaldosterone excretion, total androgen excretion, and cortisol metabolites. Aldosterone synthesis is highly heritable and is affected by genotype at CYP11B1. Variation in the region of chromosome 8 including the genes steroid 11-beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) influences mineralocorticoid and glucocorticoid metabolism; differences in 11-hydroxylation efficiency can have downstream effects on mineralocorticoid synthesis. Such effects may be of relevance to the development of low-renin essential hypertension. Genotype differences in CYP11B1 explains approximately 5% of the variance in urinary THS excretion in the population. Excretion of THS is heritable (19.4%) and the T-allele of the -344 C/T polymorphism of CYP11B2 is more strongly associated with higher THS levels than the C-allele. PMID: 16984984, PMID: 15522937, PMID: 15272911. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Tetrahydrodeoxycortisol

LP32035-5   Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Creatinine

Fully-Specified Name

Component

Tetrahydrodeoxycortisol/Creatinine

Property

SRto

Time

24H

System

Urine

Scale

Qn

Method

Additional Names

Short Name

TH-DC/Creat 24h Ur-sRto

Display Name

Tetrahydrodeoxycortisol/Creatinine (24H U) [Molar ratio]

Consumer Name Alpha Get Info

Tetrahydrodeoxycortisol/Creatinine, Urine

Basic Attributes

Class

CHEM

Type

Laboratory

First Released

Version 2.56

Last Updated

Version 2.56

Order vs. Observation

Both

Member of these Panels

Language Variants Get Info

Related Names

• 1 day
• 24 hours
• 24HR
• Chemistry
• CR
• Crea
• Creat
• Esoteric
• QNT
• Quan
• Quant
• Quantitative
• Scrto
• Substance concentration ratio
• Substance ratio
• tetrahydro-11-deoxycortisol
• TH-DC
• UA
• UCr
• UR
• Urn

Example Units

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