8191-9

Cocaine [Presence] in Serum or Plasma by Screen method

Active

Part Descriptions

LP16048-8   Cocaine
Cocaine is an alkaloid of Erythroxylon coca that is grown in the northern South American Andes, India, Africa and Java. It is used medicinally as a local anesthetic and vasoconstrictor in nasal surgery and to dilate pupils. Because cocaine is a powerful central nervous system stimulant it is among the most abused drugs. Cocaine abuse can lead to sudden death due to cardiotoxicity or the sequential development of hyperthermia, agitated delirium and respiratory arrest. Cocaine is metabolized in the liver to inactive benzoylecgonine (BZE). BZE is pharmacologically inactive and has a longer half-life than its parent drug cocaine. It is the substance most tested for when investigating suspected cocaine abuse. Cocaethylene (CE) is produced in the liver in the presence of ethanol and has been shown to have similar stimulatory effects as cocaine in animal studies.(Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, Seventh Edition) Cocaethylene is toxic to the myocardium. PMID: 8761012 Source: Regenstrief LOINC

LP16048-8   Cocaine
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake. Source: National Library of Medicine, MeSH 2006

Reference Information

Fully-Specified Name

Component

Cocaine

Property

PrThr

Time

Pt

System

Ser/Plas

Scale

Ord

Method

Screen

Additional Names

Short Name

Cocaine SerPl Ql Scn

Display Name

Cocaine Screen Ql

Consumer Name Alpha Get Info

Cocaine, Blood

Basic Attributes

Class

DRUG/TOX

Type

Laboratory

First Released

Version 1.0h(2)

Last Updated

Version 2.73

Change Reason

The Property has been changed from ACnc to reflect new model for ordinal terms; The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.

Order vs. Observation

Both

Common Test Rank Get Info

1253

Member of these Groups Get Info

Language Variants Get Info

Related Names

• Addiction
• Benzoylmethylecgonine
• Coke
• Crack
• DRUG/TOXICOLOGY
• Drugs
• Drugs of abuse
• Ecgonine methyl ester benzoate
• Illicit
• Ordinal
• Pl
• Plasma
• Plsm
• Point in time
• PotentialForAbuse
• PR
• QL
• Qual
• Qualitative
• Random
• Scn
• Scr
• Screen
• Scrn
• SerP
• SerPl
• SerPlas
• Serum
• Serum or plasma
• Snow
• SR
• UniversalLabOrders

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CodeSystem lookup

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LOINC Copyright

Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © 1995-2024, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.