82197-5

Clostridioides difficile toxin A+B tcdA+tcdB genes [Presence] in Stool by NAA with non-probe detection

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Term Description

Qualitative detection of nucleic acid sequences in the Clostridium difficile toxin A (tcdA) and B (tcdB) genes in stool specimens by PCR and non-probe detection methods, such as melt curve analysis. This assay does not differentiate between C. difficile toxin A and B genes. This term was created for, but not limited in use to, the submitter's test kit, FilmArray Gastrointestinal Panel (GI) v2.1.

Part Description

LP204848-8 Clostridioides difficile toxin A+B tcdA+tcdB genes
Clostridium difficile toxin's A and B are encoded by the tcdA and tcdB genes, respectively. PMID: 20664812 They share similar molecular characteristics with comparable sizes (308 kD for tcdA and 269 for tcdB) and 63% homology in their amino acid sequences. PMID: 9312171 TcdA and tcdB are expressed in response to environmental stresses, such as antibiotics.[ PMID 15831824] Nucleic acid sequences within these genes are targeted to confirm the presence of C. difficile toxins and diagnose the cause of diarrhea, abdominal pain, fever, nausea and other toxin-producing symptoms. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Clostridioides difficile toxin A+B tcdA+tcdB genes:PrThr:Pt:Stool:Ord:Non-probe.amp.tar
Long Common Name: Clostridioides difficile toxin A+B tcdA+tcdB genes [Presence] in Stool by NAA with non-probe detection
Short Name: C dif tox tcdA+tcdB Stl Ql NAA+n-prb
Display Name: C. difficile toxin A+B tcdA+tcdB genes NAA+non-probe Ql (Stl)
Consumer Name Alpha Get Info: Clostridioides difficile toxin A+B tcdA+tcdB genes, Stool

Part Model Get Info

Component
Clostridioides difficile toxin A+B tcdA+tcdB genes
LP204848-8
- Analyte
  Clostridioides difficile toxin A+B tcdA+tcdB genes
  LP204848-8
  - Component Numerator
    Clostridioides difficile toxin A+B tcdA+tcdB genes
    LP204848-8
    - Component Numerator Core
      Clostridioides difficile toxin A+B tcdA+tcdB genes
      LP204848-8
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Stool
LP7604-4
- System Core
  Stool
  LP7604-4
- Super System
  NULL
Scale
Ord
LP7751-3
Method
Non-probe.amp.tar
LP208998-7

Example Answer List: LL744-4

Source: Regenstrief Institute

Answer	Code	Score	Answer ID
Detected			LA11882-0
Not detected			LA11883-8

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.56
Last Updated: Version 2.82 (MIN)
Change Reason: Updated Component from "Clostridium difficile toxin A+B (tcdA+tcdB) genes" based on the current LOINC naming model for assays that detect specific bacteria and viral genes; Updated genus name from Clostridium to Clostridioides based on current (2019) accepted nomenclature for this genus [PMID:27370902].
Order vs. Observation: Both
Common Test Rank Get Info: 1430

Member of these Panels

LOINC	Long Common Name
114501-0	Gastrointestinal pathogens 11-plexA DNA and RNA panel - Stool
114488-0	Gastrointestinal pathogens 22-plexA DNA and RNA panel - Stool by NAA with non-probe detection
82195-9	Gastrointestinal pathogens DNA and RNA panel - Stool by NAA with non-probe detection

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Clostridioides difficile toxin A+B geny tcdA+tcdB:Přítomnost nebo práh:Časový bod:Stolice:Ordinální:Amplifikace nukleových kyselin s detekcí bez sondy
el-GR	Greek (Greece)	Γονίδια tcdA+tcdB τοξίνης Α+Β του Clostridioides difficile:PrThr:Pt:Κόπρανα:Ord:Χωρίς ανιχνευτή.ενίσχυση.στόχου Synonyms: A A,B B Clostridioides difficile MICRO Ord PrThr Pt Ανιχνευτής Ανιχνευτής.ενίσχυση Ανιχνευτής.ενίσχυση.στόχου Γονίδια tcdA+tcdB τοξίνης Α+Β του Clostridioides difficile Κόπρανα Τοξίνη Α του Clostridioides difficile Τοξίνη Α+Β του Clostridioides difficile Τοξίνη του Clostridioides difficile Χωρίς ανιχνευτή.ενίσχυση.στόχου
es-ES	Spanish (Spain)	Gen de la toxina del Clostridium difficile A+B (tcdA+tcdB):PrThr:Punto temporal:Heces:Ord:Amplificación del objetivo no basado en sonda
es-MX	Spanish (Mexico)	Toxina de Clostridioides difficile A + B genes tcdA + tcdB:Presencia o umbral:Punto temporal:Heces:Ordinal:Amplificación de ácidos nucleicos con detección sin sonda
fr-FR	French (France)	Clostridioides difficile toxines A+B gènes tcdA+tcdB:Présence/Seuil:Ponctuel:Selle:Qualitatif:Non-PCR amplification de cible
it-IT	Italian (Italy)	Clostridium Difficile (tcdA+tcdB), geni tossine A+B:PrThr:Pt:Feci:Ord:Non-sonda.amp.tar Synonyms: Amplificazione target non basata su sonda Geni delle tossine A+B del Clostridium Difficile ( Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA Tossina A di Clostridium difficile Tossina A+B di Clostridium difficile Tossina di Clostridium difficile
pl-PL	Polish (Poland)	Clostridioides difficile toksyny A+B tcdA+tcdB geny:granica wykrywalności:punkt w czasie:kał:uporządkowany:bez sondy.amplifikacja.cel Synonyms: amplifikacja kwasu nukleinowego z detekcją bez użycia sondy amplifikacja kwasu nukleinowego z detekcją za pomocą sondy amplifikacja z detekcją za pomocą sondy Geny tcdA i tcdB kodujące toksyny A i B Clostridioides difficile
zh-CN	Chinese (China)	艰难梭菌毒素 A+B tcdA+tcdB 基因:存在情况或阈值:时间点:大便:序数型:非探针法.基因扩增.靶向 Synonyms: A 型 A,B 型;AB 型 B 型依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型便;大肠运动;排便;粪便;肠运动借助扩增的探针方法;借助扩增的探针法;探针法.扩增借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向借助靶向扩增的非探针方法;借助靶向扩增的非探针法;非探针法.扩增.靶向分子病理学 - 基因类基因存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）扩增型扩增性时刻;随机;随意;瞬间经过扩增的脱氧核糖核酸探针艰难梭状芽胞杆菌;艰难芽孢梭菌艰难梭状芽胞杆菌毒素 A;艰难梭状芽胞杆菌毒素 A 型;艰难梭菌毒素 A 型;艰难芽孢梭菌毒素 A;艰难芽孢梭菌毒素 A 型艰难梭状芽胞杆菌毒素 A+B;艰难梭状芽胞杆菌毒素 A+B 型;艰难梭菌毒素 A+B 型;艰难芽孢梭菌毒素 A+B;艰难芽孢梭菌毒素 A+B 型艰难梭状芽胞杆菌毒素;艰难芽孢梭菌毒素艰难梭菌毒素（艰难梭状芽胞杆菌、艰难芽孢梭菌） A+B tcdA+tcdB 基因

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.