82393-0

Fibrillarin Ab [Units/volume] in Serum by Line blot

Active

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.

Part Description

LP65024-9   Fibrillarin
Anti-fibrillarin antibody (AFA), also known as anti-U3-RNP, is an antibody to a nucleolar ribonucleoprotein called fibrillarin, which marks the site of formation of the nucleolus in cells that are dividing. AFA is associated with systemic sclerosis (scleroderma) and is more prevalent in African American patients with scleroderma compared to other patient populations. In addition, patients with scleroderma who have AFA tend to be younger at disease onset and have a higher frequency of diffuse cutaneous involvement, pulmonary artery hypertension, musculoskeletal and cardiac involvement, and lower frequency of arthritis. PMID: 21572159 Source: Regenstrief LOINC , PMID: 21572159

Fully-Specified Name

Component

Fibrillarin Ab

Property

ACnc

Time

Pt

System

Ser

Scale

Qn

Method

Line blot

Additional Names

Long Common Name

Fibrillarin Ab [Units/volume] in Serum by Line blot

Short Name

Fibrillarin Ab Ser Line blot-aCnc

Display Name

Fibrillarin Ab Line blot Qn (S)

Consumer Name Alpha Get Info

Fibrillarin antibody, Blood

Basic Attributes

Class

SERO

Type

Laboratory

First Released

Version 2.58

Last Updated

Version 2.73 (MIN)

Change Reason

This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.

Order vs. Observation

Both

Common Test Rank Get Info

17511

Member of these Panels

Member of these Groups Get Info

Language Variants Get Info

Related Names

• ABS
• Aby
• Antby
• Anti
• Antibodies
• Antibody
• Arbitrary concentration
• Autoantibodies
• Autoantibody
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• Serology
• Serum
• SR

Example Units

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

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CodeSystem lookup

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82393-0

LOINC Copyright

Copyright © 2025 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.