Version 2.77

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC

Part Descriptions

LP99610-5   Ganglioside GD2
Anti-ganglioside autoantibodies are one marker of multiple sclerosis (MS). In one study, about 30% of patients with MS had anti-GD2-like IgM autoantibodies, and some of those also had antibodies to GD1a and/or GD3. Presence of anti-GD2-like antibodies was associated with significantly more neurological disability compared to patients with MS that did not have anti-GD2-like antibodies. PMID: 16764343 Source: Regenstrief LOINC, PMID: 16764343

LP222219-0   Ganglioside
A ganglioside molecule consists of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acid residues linked to the sugar chain. Molecules with one sialic acid residue are called monosialogangliosides (GM), those with two are called disialogangliosides (GD), and those with three are trisialogangliosides (GT). Gangliosides without any sialic acid residues are called asialogangliosides, while those that do not have a ceramide N-acyl group are called lysogangliosides. The number that typically is included at the end of the name indicates the order in which the molecule was discovered. For example, GM2 is a ganglioside with one sialic acid residue that was the second GM to be identified. Source: Regenstrief LOINC

Fully-Specified Name

Component
Ganglioside GD2 Ab.IgM
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
Line blot

Additional Names

Short Name
GD2 Gangl IgM Ser Ql Line blot
Display Name
Ganglioside GD2 IgM Line blot Ql (S)
Consumer Name Alpha Get Info
Ganglioside GD2 IgM antibody, Blood

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.66
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
82455-7 Ganglioside Ab panel - Serum

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Gangliosido GD2 IgM:PrThr:Punto temporal:Suero:Ord:Line blot
es-MX Spanish (Mexico) Gangliósido GD2 Ab.IgM:Presencia o umbral:Punto temporal:Suero:Ordinal:Mancha de línea
fr-CA French (Canada) Ganglioside GD2 , IgM:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunoessai sur bandelette
fr-FR French (France) Ganglioside GD2 anticorps IgM:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
it-IT Italian (Italy) Ganglioside GD2 Ab.IgM:PrThr:Pt:Siero:Ord:Line blot
Synonyms: Anticorpi IgM anticorpo Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) ganglioside GD2 As.IgM:aanwezigheid:moment:serum:ordinaal:lijnblot
Synonyms: antistof; antilichaam
zh-CN Chinese (China) 神经节苷脂 GD2 抗体.IgM:存在情况或阈值:时间点:血清:序数型:线点印迹法
Synonyms: Ab.IgM;IgM;抗体 IgM Ab;自身抗体 依次型;分类顺序型;定性的;序数型(或称等级型);性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫球蛋白 M 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况(存在、存在与否、是否存在)或阈值(界值、界限、阀值、临界值) 时刻;随机;随意;瞬间 神经节糖苷 神经节糖苷 GD2;GD2 线点杂交技术;线点杂交法;线条状印迹法 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目(非微生物学);血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验(非微生物学);血清学试验类 (非微生物学);血清类

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82401-1