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Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.

Part Descriptions

LP28754-7   Ganglioside GQ1b
Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin.
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS.
1. Antibodies against GD1a/GD1b and GD1b/GT1b complexes have been found in patients with more severe GBS requiring mechanical ventilation;
2. Antibodies against GM1 or those against GalNAc-GD1a have been associated with acute motor axonal neuropathy;
3. Anti-GQ1b antibodies are specifically associated with a variant of GBS called Fisher syndrome, which is characterized by ophthalmoplegia and ataxia.
Detection of specific markers early in the course of GBS may help guide the plan of care. PMID: 21214559 Source: Regenstrief LOINC, PMID: 2121455

LP222219-0   Ganglioside
A ganglioside molecule consists of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acid residues linked to the sugar chain. Molecules with one sialic acid residue are called monosialogangliosides (GM), those with two are called disialogangliosides (GD), and those with three are trisialogangliosides (GT). Gangliosides without any sialic acid residues are called asialogangliosides, while those that do not have a ceramide N-acyl group are called lysogangliosides. The number that typically is included at the end of the name indicates the order in which the molecule was discovered. For example, GM2 is a ganglioside with one sialic acid residue that was the second GM to be identified. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Ganglioside GQ1b Ab.IgG+IgM:PrThr:Pt:Ser:Ord:Line blot
Long Common Name
Ganglioside GQ1b IgG+IgM Ab [Presence] in Serum by Line blot
Short Name
GQ1b Gangl IgG+IgM Ser Ql Line blot
Display Name
Ganglioside GQ1b IgG+IgM Line blot Ql (S)
Consumer Name Alpha Get Info
Ganglioside GQ1b IgG+IgM, Blood

Part Model Get Info

  • Component
    Ganglioside GQ1b Ab.IgG+IgM
    LP228511-4
    • Analyte
      Ganglioside GQ1b Ab.IgG+IgM
      LP228511-4
      • Component Numerator
        Ganglioside GQ1b Ab.IgG+IgM
        LP228511-4
        • Component Numerator Core
          Ganglioside GQ1b
          LP28754-7
        • Component Numerator Core Suffix
          Ab.IgG+IgM
          LP32404-3
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Ser
    LP7567-3
    • System Core
      Ser
      LP7567-3
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Line blot
    LP266806-1

Example Answer List: LL360-9

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)LA6577-6

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.66 (MIN)
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both

Member of these Panels

LOINCLong Common Name
82455-7Ganglioside Ab panel - Serum

Member of these Groups Get Info

LOINC GroupGroup Name
LG51960-9Ganglioside GQ1b Ab.IgG+IgM|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Gangliosid GQ1b Ab.IgG+IgM:Přítomnost nebo práh:Časový bod:Sérum:Ordinální:Line blot
el-GRGreek (Greece)Γαγγλιοσίδη GQ1b Αντισώματα IgG+IgM:PrThr:Pt:Ορός:Ord:Γραμμή κηλίδωσης
Synonyms: Ord PrThr Pt SERO Ανοσοσφαιρίνη G Ανοσοσφαιρίνη M Αντίσωμα Αντισώματα IgG Αντισώματα IgG & IgM Αντισώματα IgG+IgM Γαγγλιοσίδη Γαγγλιοσίδη GQ1b Γραμμή κηλίδωσης Ορός
es-ESSpanish (Spain)Gangliósido GQ1b IgG+IgM:PrThr:Punto temporal:Suero:Ord:Line blot
es-MXSpanish (Mexico)Gangliósido GQ1b Ab.IgG + IgM:Presencia o umbral:Punto temporal:Suero:Ordinal:Mancha de línea
fr-CAFrench (Canada)Ganglioside GQ1b, IgG+IgM:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunoessai sur bandelette
fr-FRFrench (France)Ganglioside GQ1b Ac IgG+IgM:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
it-ITItalian (Italy)Ganglioside GQ1b Ab.IgG+IgM:PrThr:Pt:Siero:Ord:Line blot
Synonyms: anticorpi IgG anticorpi IgG e IgM Anticorpi IgG+IgM anticorpo Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NLDutch (Netherlands)ganglioside GQ1b As.IgG + IgM:aanwezigheid:moment:serum:ordinaal:lijnblot
Synonyms: antistof; antilichaam
pl-PLPolish (Poland)Gangliozyd GQ1b Ab.IgG+IgM:granica wykrywalności:punkt w czasie:surowica:uporządkowany:line blot
Synonyms: IgG IgM Przeciwciała do gangliozydu GQ1b przeciwciała IgG Przeciwciała IgG do gangliozydu GQ1b przeciwciała IgG i IgM Przeciwciała IgG+IgM do gangliozydu GQ1b
zh-CNChinese (China)神经节苷脂 GQ1b 抗体.IgG+IgM:存在情况或阈值:时间点:血清:序数型:线点印迹法
Synonyms: Ab.IgG;IgG;抗体 IgG Ab.IgG+IgM;IgG+IgM;抗体 IgG+抗体 IgM Ab;自身抗体 GQ1b;神经节糖苷 GQ1b 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫球蛋白 G 免疫球蛋白 M 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 抗体.IgG & IgM;抗体.IgG+IgM 时刻;随机;随意;瞬间 神经节糖苷 神经节苷脂 GQ1b Ab 神经节苷脂 GQ1b Ab.IgG 神经节苷脂 GQ1b IgG 神经节苷脂 GQ1b 抗体 IgG 线点杂交技术;线点杂交法;线条状印迹法 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82410-2