Version 2.80

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.

Part Description

LP71704-8   Human upstream binding factor
Human upstream binding factor (hUBF) is a nucleolar protein that plays a key role in rRNA production. The protein regulates rDNA transcription and also promotes rRNA synthesis. DNA binding to hUBF has the potential to alter chromatin by inducing chromatin remodeling. PMID: 25965800 Autoantibodies to hUBF (anti-hUBF) are associated with various connective tissue diseases, including systemic sclerosis, Raynaud's disease, rheumatoid arthritis and systemic lupus erythematosus. Anti-hUBF antibodies have also been associated with some malignancies. Anti-hUBF and anti-nucleolus-organizing region (NOR) 90 antibodies were originally described as distinct entities but later were recognized as being the same. PMID: 20175839 Source: Regenstrief LOINC , PMID: 20175839

Fully-Specified Name

Component
Human upstream binding factor Ab
Property
ACnc
Time
Pt
System
Ser
Scale
Qn
Method
Line blot

Additional Names

Long Common Name
Human upstream binding factor Ab [Units/volume] in Serum by Line blot
Short Name
hUBF Ab Ser Line blot-aCnc
Display Name
Human upstream binding factor Ab Line blot Qn (S)
Consumer Name Alpha Get Info
Human upstream binding factor antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.68 (MIN)
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
88702-6 Systemic sclerosis panel - Serum by Immunoassay

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Ανθρώπινος παράγοντας δέσμευσης ανάντη Αντίσωμα:ACnc:Pt:Ορός:Qn:Γραμμή κηλίδωσης
Synonyms: ACnc Ανθρώπινος παράγοντας δέσμευσης ανάντη
es-ES Spanish (Spain) factor de unión upstream humano Anticuerpos:Concentración arbitraria:Punto temporal:Suero:Qn:Line blot
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Factor de unión aguas arriba Ab humano:Concentración arbitraria:Punto temporal:Suero:Cuantitativo:Mancha de línea
fr-CA French (Canada) NOR-90, Ac:Concentration arbitraire:Temps ponctuel:Sérum:Quantitatif:Immunoessai sur bandelette
fr-FR French (France) NOR-90 anticorps:Arbitraire/Volume:Ponctuel:Sérum:Numérique:Blot en ligne
it-IT Italian (Italy) Fattore umano a monte legante Ab:ACnc:Pt:Siero:Qn:Line blot
Synonyms: anticorpo Concentrazione Arbitraria hUBF Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) Humaan upstream binding factor As:eenheid/volume:moment:serum:kwantitatief:lijnblot
Synonyms: antistof; antilichaam
zh-CN Chinese (China) 人上游结合因子 抗体:任意型浓度:时间点:血清:定量型:线点印迹法
Synonyms: Ab;自身抗体 人上遊結合因子;人类上游结合因子;hUBF;Human upstream binding factor 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 因素 时刻;随机;随意;瞬间 系数 线点杂交技术;线点杂交法;线条状印迹法 结合性 结合性的 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

Unit Source
[arb'U]/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82417-7