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Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.

Part Description

LP71704-8   Human upstream binding factor
Human upstream binding factor (hUBF) is a nucleolar protein that plays a key role in rRNA production. The protein regulates rDNA transcription and also promotes rRNA synthesis. DNA binding to hUBF has the potential to alter chromatin by inducing chromatin remodeling. PMID: 25965800 Autoantibodies to hUBF (anti-hUBF) are associated with various connective tissue diseases, including systemic sclerosis, Raynaud's disease, rheumatoid arthritis and systemic lupus erythematosus. Anti-hUBF antibodies have also been associated with some malignancies. Anti-hUBF and anti-nucleolus-organizing region (NOR) 90 antibodies were originally described as distinct entities but later were recognized as being the same. PMID: 20175839 Source: Regenstrief LOINC, PMID: 20175839

LOINC Names Get Info

Fully-Specified Name
Human upstream binding factor Ab:PrThr:Pt:Ser:Ord:Line blot
Long Common Name
Human upstream binding factor Ab [Presence] in Serum by Line blot
Short Name
hUBF Ab Ser Ql Line blot
Display Name
Human upstream binding factor Ab Line blot Ql (S)
Consumer Name Alpha Get Info
Human upstream binding factor antibody, Blood

Part Model Get Info

  • Component
    Human upstream binding factor Ab
    LP71696-6
    • Analyte
      Human upstream binding factor Ab
      LP71696-6
      • Component Numerator
        Human upstream binding factor Ab
        LP71696-6
        • Component Numerator Core
          Human upstream binding factor
          LP71704-8
        • Component Numerator Core Suffix
          Ab
          LP20667-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    PrThr
    LP217195-9
  • Time
    Pt
    LP6960-1
  • System
    Ser
    LP7567-3
    • System Core
      Ser
      LP7567-3
    • Super System
      NULL
       
  • Scale
    Ord
    LP7751-3
  • Method
    Line blot
    LP266806-1

Example Answer List: LL360-9

Source: Regenstrief Institute
AnswerCodeScoreAnswer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)LA6577-6

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.66 (MIN)
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both

Member of these Groups Get Info

LOINC GroupGroup Name
LG21896-2Human upstream binding factor Ab|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Lidský faktor UBF Ab:Přítomnost nebo práh:Časový bod:Sérum:Ordinální:Line blot
de-DEGerman (Germany)Human upstream binding factor Ak:Nachweis oder Schwellenwert:Zeitpunkt:Serum:Ordinal:Line-Blot
Synonyms: NOR-90
el-GRGreek (Greece)Ανθρώπινος παράγοντας δέσμευσης ανάντη Αντίσωμα:PrThr:Pt:Ορός:Ord:Γραμμή κηλίδωσης
Synonyms: Ord PrThr Pt SERO Ανθρώπινος παράγοντας δέσμευσης ανάντη Αντίσωμα Γραμμή κηλίδωσης Ορός
es-ESSpanish (Spain)factor de unión upstream humano Anticuerpos:PrThr:Punto temporal:Suero:Ord:Line blot
es-MXSpanish (Mexico)Factor de unión aguas arriba Ab humano:Presencia o umbral:Punto temporal:Suero:Ordinal:Mancha de línea
fr-CAFrench (Canada)NOR-90, Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunoessai sur bandelette
fr-FRFrench (France)NOR-90 Ac:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
it-ITItalian (Italy)Fattore umano a monte legante Ab:PrThr:Pt:Siero:Ord:Line blot
Synonyms: anticorpo hUBF Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NLDutch (Netherlands)Humaan upstream binding factor As:aanwezigheid:moment:serum:ordinaal:lijnblot
Synonyms: antistof; antilichaam
zh-CNChinese (China)人上游结合因子 抗体:存在情况或阈值:时间点:血清:序数型:线点印迹法
Synonyms: Ab;自身抗体 人上遊結合因子;人类上游结合因子;hUBF;Human upstream binding factor 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 因素 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 系数 线点杂交技术;线点杂交法;线条状印迹法 结合性 结合性的 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82418-5