Version 2.80

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.

Part Description

LP157266-0   Platelet-derived growth factor receptor
Antibodies to the platelet derived growth factor receptor (PDGFR) are a marker of systemic sclerosis. Anti-PDGFR antibodies activate the PDGFR and stimulate production of reactive oxygen species (ROS) and collagen. In contrast to normal PDGF receptor activation, which is typically short-lived, PDGFR antibodies cause persistent activation and therefore prolonged stimulation of ROS production and collagen overproduction, which leads to fibrosis. PMID: 18083509 Source: Regenstrief LOINC , PMID: 18083509

Fully-Specified Name

Component
Platelet-derived growth factor receptor Ab
Property
ACnc
Time
Pt
System
Ser
Scale
Qn
Method
Line blot

Additional Names

Long Common Name
Platelet-derived growth factor receptor Ab [Units/volume] in Serum by Line blot
Short Name
PDGFR Ab Ser Line blot-aCnc
Display Name
Platelet-derived growth factor receptor Ab Line blot Qn (S)
Consumer Name Alpha Get Info
Platelet-derived growth factor receptor antibody, Blood

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.66 (MIN)
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both

Member of these Panels

LOINC Long Common Name
88702-6 Systemic sclerosis panel - Serum by Immunoassay

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Υποδοχέας αιμοπεταλιακού αυξητικού παράγοντα Αντίσωμα:ACnc:Pt:Ορός:Qn:Γραμμή κηλίδωσης
Synonyms: ACnc Αιμοπετάλιο Υποδοχέας αιμοπεταλιακού αυξητικού παράγοντα
es-ES Spanish (Spain) Receptor del factor de crecimiento derivado de plaquetas Anticuerpos:Concentración arbitraria:Punto temporal:Suero:Qn:Line blot
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Receptor Ab del factor de crecimiento derivado de plaquetas:Concentración arbitraria:Punto temporal:Suero:Cuantitativo:Mancha de línea
fr-FR French (France) PDGF récepteur anticorps:Arbitraire/Volume:Ponctuel:Sérum:Numérique:Blot en ligne
it-IT Italian (Italy) Fattore di crescita derivato dalle piastrine, recettore Ab:ACnc:Pt:Siero:Qn:Line blot
Synonyms: anticorpo Concentrazione Arbitraria Piastrine Punto nel tempo (episodio) Recettore del fattore di crescita derivato dalle piastrine Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) Trombocyten-afgeleide groeifactorreceptor As:eenheid/volume:moment:serum:kwantitatief:lijnblot
Synonyms: antistof; antilichaam
pl-PL Polish (Poland) Receptor płytkopochodnego czynnika wzrostu Ab:stężenie w jednostkach umownych:punkt w czasie:surowica:ilościowy:line blot
Synonyms: Przeciwciała do receptora płytkopochodnego czynnika wzrostu
zh-CN Chinese (China) 血小板衍生生长因子受体 抗体:任意型浓度:时间点:血清:定量型:线点印迹法
Synonyms: Ab;自身抗体 Platelet-derived growth factor receptor;PDGF-R;血小板衍生性生长因子受体;血小板源生长因子受体 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 因素 时刻;随机;随意;瞬间 系数 线点杂交技术;线点杂交法;线条状印迹法 血栓细胞 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

Unit Source
[IU]/L Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82431-8