Log In

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.

Part Description

LP157266-0   Platelet-derived growth factor receptor
Antibodies to the platelet derived growth factor receptor (PDGFR) are a marker of systemic sclerosis. Anti-PDGFR antibodies activate the PDGFR and stimulate production of reactive oxygen species (ROS) and collagen. In contrast to normal PDGF receptor activation, which is typically short-lived, PDGFR antibodies cause persistent activation and therefore prolonged stimulation of ROS production and collagen overproduction, which leads to fibrosis. PMID: 18083509 Source: Regenstrief LOINC, PMID: 18083509

LOINC Names Get Info

Fully-Specified Name
Platelet-derived growth factor receptor Ab:ACnc:Pt:Ser:Qn:Line blot
Long Common Name
Platelet-derived growth factor receptor Ab [Units/volume] in Serum by Line blot
Short Name
PDGFR Ab Ser Line blot-aCnc
Display Name
Platelet-derived growth factor receptor Ab Line blot Qn (S)
Consumer Name Alpha Get Info
Platelet-derived growth factor receptor antibody, Blood

Part Model Get Info

  • Component
    Platelet-derived growth factor receptor Ab
    LP157208-2
    • Analyte
      Platelet-derived growth factor receptor Ab
      LP157208-2
      • Component Numerator
        Platelet-derived growth factor receptor Ab
        LP157208-2
        • Component Numerator Core
          Platelet-derived growth factor receptor
          LP157266-0
        • Component Numerator Core Suffix
          Ab
          LP20667-9
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    ACnc
    LP6773-8
  • Time
    Pt
    LP6960-1
  • System
    Ser
    LP7567-3
    • System Core
      Ser
      LP7567-3
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    Line blot
    LP266806-1

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.66 (MIN)
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both

Member of these Panels

LOINCLong Common Name
88702-6Systemic sclerosis Ab panel - Serum by Immunoassay

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Růstový faktor odvozený z trombocytů receptor Ab:Arbitrární koncentrace:Časový bod:Sérum:Kvantitativní:Line blot
el-GRGreek (Greece)Υποδοχέας αιμοπεταλιακού αυξητικού παράγοντα Αντίσωμα:ACnc:Pt:Ορός:Qn:Γραμμή κηλίδωσης
Synonyms: ACnc Pt Qn SERO Αιμοπετάλιο Αντίσωμα Γραμμή κηλίδωσης Ορός Υποδοχέας αιμοπεταλιακού αυξητικού παράγοντα
es-ESSpanish (Spain)Receptor del factor de crecimiento derivado de plaquetas Anticuerpos:Concentración arbitraria:Punto temporal:Suero:Qn:Line blot
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Receptor Ab del factor de crecimiento derivado de plaquetas:Concentración arbitraria:Punto temporal:Suero:Cuantitativo:Mancha de línea
fr-FRFrench (France)PDGF récepteur Ac:Arbitraire/Volume:Ponctuel:Sérum:Numérique:Blot en ligne
it-ITItalian (Italy)Fattore di crescita derivato dalle piastrine, recettore Ab:ACnc:Pt:Siero:Qn:Line blot
Synonyms: anticorpo Concentrazione Arbitraria Piastrine Punto nel tempo (episodio) Recettore del fattore di crescita derivato dalle piastrine Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NLDutch (Netherlands)Trombocyten-afgeleide groeifactorreceptor As:eenheid/volume:moment:serum:kwantitatief:lijnblot
Synonyms: antistof; antilichaam
pl-PLPolish (Poland)Receptor płytkopochodnego czynnika wzrostu Ab:stężenie w jednostkach umownych:punkt w czasie:surowica:ilościowy:line blot
Synonyms: Przeciwciała do receptora płytkopochodnego czynnika wzrostu
zh-CNChinese (China)血小板衍生生长因子受体 抗体:任意型浓度:时间点:血清:定量型:线点印迹法
Synonyms: Ab;自身抗体 Platelet-derived growth factor receptor;PDGF-R;血小板衍生性生长因子受体;血小板源生长因子受体 任意型浓度(单位体积);任意浓度;单位体积的任意单位数;人工型浓度 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 因素 时刻;随机;随意;瞬间 系数 线点杂交技术;线点杂交法;线条状印迹法 血栓细胞 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

UnitSource
[IU]/LExample UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82431-8