82471-4

Borrelia garinii+afzelii oppA1 gene [Presence] in Blood by NAA with non-probe detection

Active

Term Description

The DNA amplification target is the 283-bp plasminogen-binding protein gene (oppA1), which is present at a frequency of one copy per organism in all four pathogenic species of the Borrelia burgdorferi sensu lato genogroup (Borrelia burgdorferi sensu stricto, Borrelia afzelii, Borrelia garinii, and Borrelia mayonii). Melting curve analysis is used to differentiate B. afzelii and B. garinii from the other two species but cannot differentiate between B. afzelii and B. garinii.

Part Descriptions

LP220480-0   Borrelia garinii+afzelii oppA1 gene
Lyme disease is a multisystem, multistage infection caused by three species of tick-borne spirochetes in the Borrelia burgdorferi sensu lato genogroup. These spirochetes include B. burgdorferi sensu stricto (North America and Western Europe), B. afzelii (Central and Western Europe and Russia), and B. garinii (Europe, Russia, and northern Asia). Endemic areas for Lyme disease in the United States correspond with the distribution of two tick species, Ixodes dammini (Northeastern and Upper Midwestern US) and Ixodes pacificus (West Coast US). In Europe, Ixodes ricinus transmits the spirochete. Human Lyme borreliosis, the most prevalent arthropod-borne infection in temperate climate zones around the world, is an inflammatory disorder characterized by the skin lesion erythema migrans and the potential development of neurologic, cardiac, and joint abnormalities. B. garinii, the most neurotropic of these three genospecies, causes most neurologic Lyme disease in Europe, including cases of meningopolyneuritis and, rarely, encephalomyelitis. Although probably all three genospecies can cause all major manifestations, it appears that infection with different B. burgdorferi sensu lato genospecies results in distinct presentations of Lyme borreliosis. In Europe, B. afzelii is mostly associated with skin manifestations, such as erythema migrans, and acrodermatitis chronica atrophicans, whereas B. garinii is the main cause of Lyme neuroborreliosis. Patients with B. garinii isolated from CSF samples have a distinct clinical presentation, compared with that of patients with B. afzelii infection. PMID: 16912943 PMID: 12454161 Source: Regenstrief LOINC

LP220480-0   Borrelia garinii+afzelii oppA1 gene
The oppA1 gene is a member of a family of three genes; oppA-1, oppA-2, and oppA-3, that encode predicted peptide-binding proteins. Peptide-binding protein dependent transport systems are recognized to play important roles in microbial cell signaling and virulence. PMID: 9712756 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name

Borrelia garinii+afzelii oppA1 gene:PrThr:Pt:Bld:Ord:Non-probe.amp.tar

Long Common Name

Borrelia garinii+afzelii oppA1 gene [Presence] in Blood by NAA with non-probe detection

Short Name

B gar+afz oppA1 Bld Ql NAA+n-prb

Display Name

B. garinii+afzelii oppA1 gene NAA+non-probe Ql (Bld)

Consumer Name Alpha Get Info

Borrelia garinii+afzelii oppA1 gene, Blood

Part Model Get Info

• Component

  Borrelia garinii+afzelii oppA1 gene
  LP220480-0

  • Analyte

    Borrelia garinii+afzelii oppA1 gene
    LP220480-0

    • Component Numerator

      Borrelia garinii+afzelii oppA1 gene
      LP220480-0

      • Component Numerator Core

        Borrelia garinii+afzelii oppA1 gene
        LP220480-0

      • Component Numerator Core Suffix

        NULL
         

    • Component Denominator

      NULL
       

      • Component Denominator Core

        NULL
         

      • Component Denominator Core Suffix

        NULL
         

  • Challenge

    NULL
     

  • Adjustment

    NULL
     

  • Count

    NULL
     

• Property

  PrThr
  LP217195-9

• Time

  Pt
  LP6960-1

  • Time Core

    Pt
    LP6960-1

  • Time Modifier

    NULL
     

• System

  Bld
  LP7057-5

  • System Core

    Bld
    LP7057-5

  • Super System

    NULL
     

• Scale

  Ord
  LP7751-3

• Method

  Non-probe.amp.tar
  LP208998-7

Example Answer List: LL360-9

Basic Attributes

Class

MICRO

Type

Laboratory

First Released

Version 2.58

Last Updated

Version 2.82 (MIN)

Change Reason

Release 2.68: COMPONENT: Removed parentheses from Component for consistency and accuracy.; Previous Releases:

Order vs. Observation

Both

Member of these Panels

Language Variants Get Info

Related Names

• 3 Self-Sustaining Sequence Replication
• 3SR SR
• Acrodermatitis chronica atrophicans
• Amplif
• Amplification
• Amplified
• B gar+afz oppA1
• B garinii
• Blood
• Borreliosis, Lyme
• DNA NUCLEIC ACID PROBE
• DNA probe
• Erythema migrans
• ID
• Infectious Disease
• InfectiousDisease
• LAT
• LCR
• Ligase chain reaction
• Ligation-activated transcription
• Meningopolyneuritis
• Microbiology
• NAA+n-prb
• NAA+probe
• NAAT
• NASBA
• Nucleic acid sequence based analysis
• Ordinal
• PCR
• Point in time
• Polymerase chain reaction
• PR
• Probe amp
• Probe with ampification
• Probe with target amplification
• QBR
• QL
• Qual
• Qualitative
• Random
• Screen
• SDA
• Strand Displacement Amplification
• Tick Borne Diseases
• TMA
• Transcription mediated amplification
• WB
• Whole blood

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CodeSystem lookup

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.