LOINC
Version 2.67

82472-2Borrelia garinii+afzelii oppA1 gene [Presence] in Unspecified specimen by NAA with non-probe detectionActive

Term Description

The DNA amplification target is the 283-bp plasminogen-binding protein gene (oppA1), which is present at a frequency of one copy per organism in all four pathogenic species of the Borrelia burgdorferi sensu lato genogroup (Borrelia burgdorferi sensu stricto, Borrelia afzelii, Borrelia garinii, and Borrelia mayonii). Melting curve analysis is used to differentiate B. afzelii and B. garinii from the other two species but cannot differentiate between B. afzelii and B. garinii. Potential specimens include CSF, tissue, and synovial fluid.
Source: Regenstrief LOINC

Part Descriptions

LP220480-0   Borrelia garinii+afzelii (oppA1) gene
Lyme disease is a multisystem, multistage infection caused by three species of tick-borne spirochetes in the Borrelia burgdorferi sensu lato genogroup. These spirochetes include B. burgdorferi sensu stricto (North America and Western Europe), B. afzelii (Central and Western Europe and Russia), and B. garinii (Europe, Russia, and northern Asia). Endemic areas for Lyme disease in the United States correspond with the distribution of two tick species, Ixodes dammini (Northeastern and Upper Midwestern US) and Ixodes pacificus (West Coast US). In Europe, Ixodes ricinus transmits the spirochete. Human Lyme borreliosis, the most prevalent arthropod-borne infection in temperate climate zones around the world, is an inflammatory disorder characterized by the skin lesion erythema migrans and the potential development of neurologic, cardiac, and joint abnormalities. B. garinii, the most neurotropic of these three genospecies, causes most neurologic Lyme disease in Europe, including cases of meningopolyneuritis and, rarely, encephalomyelitis. Although probably all three genospecies can cause all major manifestations, it appears that infection with different B. burgdorferi sensu lato genospecies results in distinct presentations of Lyme borreliosis. In Europe, B. afzelii is mostly associated with skin manifestations, such as erythema migrans, and acrodermatitis chronica atrophicans, whereas B. garinii is the main cause of Lyme neuroborreliosis. Patients with B. garinii isolated from CSF samples have a distinct clinical presentation, compared with that of patients with B. afzelii infection. [PMID: 16912943] [PMID: 12454161] Source: Regenstrief LOINC

LP220480-0   Borrelia garinii+afzelii (oppA1) gene
The oppA1 gene is a member of a family of three genes; oppA-1, oppA-2, and oppA-3, that encode predicted peptide-binding proteins. Peptide-binding protein dependent transport systems are recognized to play important roles in microbial cell signaling and virulence. [PMID: 9712756] Source: Regenstrief LOINC

Fully-Specified Name

Component
Borrelia garinii+afzelii (oppA1) gene
Property
PrThr
Time
Pt
System
XXX
Scale
Ord
Method
Non-probe.amp.tar

Additional Names

Short Name
B gar+afz (oppA1) XXX Ql NAA+non-probe
Display Name
B. garinii+afzelii oppA1 gene NAA+non-probe Ql (Unsp spec)

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.65
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
加里疏螺旋体+阿夫塞疏螺旋体 (oppA1) 基因:存在情况或阈值:时间点:XXX:序数型:非探针法.基因扩增.靶向
fr-FRFrench (FRANCE)
Borrelia garinii+afzelii oppA1 gène:Présence/Seuil:Ponctuel:Milieux divers:Qualitatif:Non-PCR amplification de cible
it-ITItalian (ITALY)
Borrelia garinii+afzelii (oppA1), gene:PrThr:Pt:XXX:Ord:Non-sonda.amp.tar
es-ESSpanish (SPAIN)
Gen oppA1 de Borrelia garinii+afzelii:PrThr:Punto temporal:XXX:Ord:Amplificación del objetivo no basado en sonda

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