LOINC
Version 2.67

82734-5AMPAR1 IgG Ab [Presence] in Serum or Plasma by ImmunofluorescenceActive

Part Description

LP229976-8   Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor 1
Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor 1 (AMPAR1) and AMPA receptor 2 (AMPAR2) antibodies target the AMPA receptor, an ionotropic glutamate receptor and key excitatory neurotransmitter. AMPA receptors are comprised of different combinations of four glutamate receptor subunits called GluA1–GluA4 (also known as GluR1–GluR4 and GluR-A to GluR-D). They are vital for brain development and function, such as memory and cognitive development. Detection of antineuronal autoantibodies against AMPA receptors aids in the diagnosis of autoimmune encephalopathies, especially limbic encephalitis, and related conditions.[PMCID: PMC4478035] The presence of AMPA antibodies may also indicate an undiscovered tumor in the thymus, lung or breast. [PMID: 23983888] The neurological symptoms associated with AMPA receptor 1 antibodies include altered mental status, convulsions, memory loss amnesia, auditory hallucinations, limbic encephalitis, abnormal behavior, schizophrenia, dizziness and hyperthermia. The neurological symptoms associated with AMPA receptor 2 antibodies include seizures, short-term memory loss, limbic encephalitis, altered mental status, chorea and facial dyskinesia. [PMID: 24707504] Source: Regenstrief LOINC

Fully-Specified Name

Component
Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor 1 Ab.IgG
Property
PrThr
Time
Pt
System
Ser/Plas
Scale
Ord
Method
IF

Additional Names

Short Name
AMPAR1 IgG SerPl Ql IF
Display Name
AMPAR1 IgG IF Ql

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.58
Order vs. Observation
Both

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Language Variants Get Info

zh-CNChinese (CHINA)
Alpha-氨基-3-羟基-5-甲基-4-异噁唑丙酸受体 1 抗体.IgG:存在情况或阈值:时间点:血清/血浆:序数型:免疫荧光法
nl-NLDutch (NETHERLANDS)
alfa-amino-3-hydroxy-5-methyl-4-isoxazolpropionaatreceptor 1 As.IgG:aanwezigheid:moment:serum of plasma:ordinaal:immunofluorescentie
fr-FRFrench (FRANCE)
AMPA récepteur 1 anticorps IgG:Présence/Seuil:Ponctuel:Sérum/Plasma:Qualitatif:Immunofluorescence
de-ATGerman (AUSTRIA)
AMPAR1-AK IgG ql.
it-ITItalian (ITALY)
Recettore tipo 1 per alfa-amino-3-idrossi-5metil-4-isoxazolepropionato , Ab.IgG:PrThr:Pt:Siero/Plasma:Ord:IF
es-ESSpanish (SPAIN)
Receptor 1 de Alfa-amino-3-hidroxi-5-metil-4-isoxazolepropionato IgG:PrThr:Punto temporal:Suero o Plasma:Ord:Inmunofluorescencia (IF)

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=82734-5