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Part Description

LP230261-2   MAOA gene.upstream VNTR repeats
MAOA (monoamine oxidase A) gene is located on the X chromosome and produces the monoamine oxidase A (MAO-A), an enzyme that degrades amine neurotransmitters, such as dopamine, norepinephrine, and serotonin. PMCID: PMC1683299 A polymorphism located upstream of the MAOA gene contains a 30 base pair variable number of tandem repeats sequence (VNTR) with 2, 3, 3.5, 4, or 5 repeated copies. The polymorphism has been shown to affect the transcriptional activity of the MAOA gene promoter by gene fusion. Transcription of the 2 or 3-repeat (short) alleles results in reduced MAOA activity and consequently increased levels of serotonin and other amine neurotransmitters, which is thought to increase the risk for aggression and psychiatric disorders. PMCID: PMC4377966 Alleles consisting of 3.5 or 4 repeats have shown higher MAOA gene expression and activity than those with 3 repeats. PMID: 17692293 Disorders associated with the upstream VNTR (uVNTR) genotype and resulting MAO-A enzyme activity include Alzheimer's disease, aggression, panic disorder, bipolar affective disorder, major depressive disorder, and attention deficit hyperactivity disorder. PMID: 25810277 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
MAOA gene.upstream VNTR repeats:EntNum:Pt:Bld/Tiss:Qn:Molgen
Long Common Name
MAOA gene upstream VNTR repeats [Entitic number] in Blood or Tissue by Molecular genetics method
Short Name
MAOA uVNTR EntNum Bld/T
Display Name
MAOA gene upstream VNTR repeats Molgen (Bld/Tiss) [Entitic number]
Consumer Name Alpha Get Info
MAOA gene Upstream VNTR Repeats, Blood or tissue specimen

Part Model Get Info

  • Component
    MAOA gene.upstream VNTR repeats
    LP230261-2
    • Analyte
      MAOA gene.upstream VNTR repeats
      LP230261-2
      • Component Numerator
        MAOA gene.upstream VNTR repeats
        LP230261-2
        • Component Numerator Core
          MAOA gene.upstream VNTR repeats
          LP230261-2
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    EntNum
    LP6806-6
  • Time
    Pt
    LP6960-1
  • System
    Bld/Tiss
    LP7061-7
    • System Core
      Bld/Tiss
      LP7061-7
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    Molgen
    LP6404-0

Basic Attributes

Class
MOLPATH.NUCREPEAT
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.58 (ADD)
Order vs. Observation
Both

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Gen MAOA upstream repetitivní sekvence VNTR:Entitní počet:Časový bod:Krev/tkáň:Kvantitativní:Molekulární genetika
el-GRGreek (Greece)Γονίδιο MAOA.ανάντη VNTR επαναλήψεις:EntNum:Pt:Αίμα/Ιστός:Qn:Μοριακή γενετική
Synonyms: EntNum MOLPATH MOLPATH.NUCREPEAT Pt Qn Αίμα Αίμα/Ιστός Γονίδιο Γονίδιο MAOA.ανάντη VNTR επαναλήψεις Ιστός Μοριακή γενετική
es-ESSpanish (Spain)Gen MAOA. Repeticiones VNTR en región promotora:Número entítico:Punto temporal:Sangre o tejido:Qn:Genética molecular
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Repetición VNTR corriente arriba del gen MAOA:Número entitic:Punto temporal:Sangre o tejido:Cuantitativo:Genética molecular
fr-FRFrench (France)MAOA gène répétitions VNTR en amont:Nombre/entité:Ponctuel:Sang/Tissu:Numérique:Biologie moléculaire
it-ITItalian (Italy)MAOA, gene.ripetizioni VNTR a monte:EntNum:Pt:Sangue/Tess:Qn:Molgen
Synonyms: Gene MAOA ripetizioni VNTR a monte Genetica molecolare Numero entitico Patologia molecolare Punto nel tempo (episodio) Ripetizione nucleotidi Sangue Sangue o Tessuto Tessuto & Strisci
nl-NLDutch (Netherlands)MAOA-gen.upstream VNTR repeats:aantal/eenheid:moment:bloed of weefsel:kwantitatief:moleculair genetisch onderzoek
Synonyms: MAOA gen.upstream VNTR repeats molgen
pl-PLPolish (Poland)MAOA gen.powtórzenia VNTR powyżej regionu genu:liczba zawarta w:punkt w czasie:krew lub tkanka:ilościowy:genetyka molekularna
Synonyms: diagnostyka molekularna Powtórzenia VNTR powyżej regionu genu MAOA
zh-CNChinese (China)MAOA 基因.上游 VNTR 重复序列:实体数量:时间点:全血/组织:定量型:分子遗传学类实验室方法
Synonyms: 全血或组织;血液/组织;血液或组织 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 单胺氧化酶 A 基因;Monoamine oxidase A gene;MAOA 基因;MAO-A 基因 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 实体计数 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 血;血液 遗传基因;遗传因子;吉恩;生物基因 重复

Example Units

UnitSource
{repeats}Example UCUM Units

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